Cell-Based Therapies for Rotator Cuff Injuries: An Updated Review of the Literature
This review focuses on non-surgical treatment options for rotator cuff injuries and highlights the potential of mesenchymal stem cells (MSCs) as a potential regenerative approach. MSCs, sourced from various tissues like bone marrow and adipose tissue, exhibit promising mechanisms in vitro, influenci...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-03-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/25/6/3139 |
| _version_ | 1797240772901208064 |
|---|---|
| author | Nicholas Hooper Anuj Marathe Nitin B. Jain Prathap Jayaram |
| author_facet | Nicholas Hooper Anuj Marathe Nitin B. Jain Prathap Jayaram |
| author_sort | Nicholas Hooper |
| collection | DOAJ |
| description | This review focuses on non-surgical treatment options for rotator cuff injuries and highlights the potential of mesenchymal stem cells (MSCs) as a potential regenerative approach. MSCs, sourced from various tissues like bone marrow and adipose tissue, exhibit promising mechanisms in vitro, influencing tendon-related gene expression and microenvironment modulation. Animal studies support this, showcasing MSCs’ ability to reduce inflammation, improve tissue remodeling, and enhance repaired tendon strength. Human trials, while varied and limited, suggest that MSCs might lower retear rates and enhance post-repair outcomes, but randomized controlled trials yield mixed results, emphasizing the necessity for standardized investigations. Ultimately, while cell-based therapies demonstrate an excellent safety profile, more rigorous clinical trials are necessary to determine their efficacy in improving patient outcomes and achieving lasting structural changes in rotator cuff injuries. |
| first_indexed | 2024-04-24T18:12:45Z |
| format | Article |
| id | doaj.art-c00f5b30d6d84ed2b9be27ce1f874168 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-04-24T18:12:45Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-c00f5b30d6d84ed2b9be27ce1f8741682024-03-27T13:45:08ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-03-01256313910.3390/ijms25063139Cell-Based Therapies for Rotator Cuff Injuries: An Updated Review of the LiteratureNicholas Hooper0Anuj Marathe1Nitin B. Jain2Prathap Jayaram3Department of Physical Medicine and Rehabilitation, Emory University, Atlanta, GA 30322, USADepartment of Physical Medicine and Rehabilitation, Emory University, Atlanta, GA 30322, USADepartment of Physical Medicine Rehab and Orthopedics, University of Michigan at Ann Arbor, Ann Arbor, MI 48109, USADepartment of Orthopedics, Physical Medicine and Rehabilitation, Emory University, Atlanta, GA 30322, USAThis review focuses on non-surgical treatment options for rotator cuff injuries and highlights the potential of mesenchymal stem cells (MSCs) as a potential regenerative approach. MSCs, sourced from various tissues like bone marrow and adipose tissue, exhibit promising mechanisms in vitro, influencing tendon-related gene expression and microenvironment modulation. Animal studies support this, showcasing MSCs’ ability to reduce inflammation, improve tissue remodeling, and enhance repaired tendon strength. Human trials, while varied and limited, suggest that MSCs might lower retear rates and enhance post-repair outcomes, but randomized controlled trials yield mixed results, emphasizing the necessity for standardized investigations. Ultimately, while cell-based therapies demonstrate an excellent safety profile, more rigorous clinical trials are necessary to determine their efficacy in improving patient outcomes and achieving lasting structural changes in rotator cuff injuries.https://www.mdpi.com/1422-0067/25/6/3139orthobiologicsrotator cuff tearsmesenchymal stem cells |
| spellingShingle | Nicholas Hooper Anuj Marathe Nitin B. Jain Prathap Jayaram Cell-Based Therapies for Rotator Cuff Injuries: An Updated Review of the Literature International Journal of Molecular Sciences orthobiologics rotator cuff tears mesenchymal stem cells |
| title | Cell-Based Therapies for Rotator Cuff Injuries: An Updated Review of the Literature |
| title_full | Cell-Based Therapies for Rotator Cuff Injuries: An Updated Review of the Literature |
| title_fullStr | Cell-Based Therapies for Rotator Cuff Injuries: An Updated Review of the Literature |
| title_full_unstemmed | Cell-Based Therapies for Rotator Cuff Injuries: An Updated Review of the Literature |
| title_short | Cell-Based Therapies for Rotator Cuff Injuries: An Updated Review of the Literature |
| title_sort | cell based therapies for rotator cuff injuries an updated review of the literature |
| topic | orthobiologics rotator cuff tears mesenchymal stem cells |
| url | https://www.mdpi.com/1422-0067/25/6/3139 |
| work_keys_str_mv | AT nicholashooper cellbasedtherapiesforrotatorcuffinjuriesanupdatedreviewoftheliterature AT anujmarathe cellbasedtherapiesforrotatorcuffinjuriesanupdatedreviewoftheliterature AT nitinbjain cellbasedtherapiesforrotatorcuffinjuriesanupdatedreviewoftheliterature AT prathapjayaram cellbasedtherapiesforrotatorcuffinjuriesanupdatedreviewoftheliterature |