The IGF2/IGF1R/Nanog Signaling Pathway Regulates the Proliferation of Acute Myeloid Leukemia Stem Cells

The IGF2/IGF1R/Nanog Signaling Pathway Regulates the Proliferation of Acute Myeloid Leukemia Stem Cells

Acute myeloid leukemia is an aggressive disease characterized by clonal proliferation and differentiation into immature hematopoietic cells of dysfunctional myeloid precursors. Accumulating evidence shows that CD34+CD38- leukemia stem cells (LSCs) are responsible for drug resistance, metastasis, and...

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Bibliographic Details
Main Authors: Dan-dan Xu, Ying Wang, Peng-jun Zhou, Shu-rong Qin, Rong Zhang, Yi Zhang, Xue Xue, Jianping Wang, Xia Wang, Hong-ce Chen, Xiao Wang, Yu-wei Pan, Li Zhang, Hai-zhao Yan, Qiu-ying Liu, Zhong Liu, Su-hong Chen, Hong-yuan Chen, Yi-fei Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Pharmacology
Subjects:
Nanog
IGF2
IGF1R
proliferation
leukemia stem cells
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00687/full

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