Effects of iron on Vitamin D metabolism: A systematic review
Vitamin D is a prohormone nutrient, which is involved in skeletal and extra-skeletal functions. Iron is another essential nutrient that is necessary for the production of red blood cells and oxygen transport. This element plays important roles in enzymatic systems including those required for Vitami...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | International Journal of Preventive Medicine |
| Subjects: | |
| Online Access: | http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2016;volume=7;issue=1;spage=126;epage=126;aulast=Azizi-Soleiman |
| _version_ | 1828325726812635136 |
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| author | Fatemeh Azizi-Soleiman Mohammadreza Vafa Behnaz Abiri Morteza Safavi |
| author_facet | Fatemeh Azizi-Soleiman Mohammadreza Vafa Behnaz Abiri Morteza Safavi |
| author_sort | Fatemeh Azizi-Soleiman |
| collection | DOAJ |
| description | Vitamin D is a prohormone nutrient, which is involved in skeletal and extra-skeletal functions. Iron is another essential nutrient that is necessary for the production of red blood cells and oxygen transport. This element plays important roles in enzymatic systems including those required for Vitamin D activation. To the best of our knowledge, there is no exclusive review on the relationship between iron deficiency anemia (IDA), as the most prevalent type of anemia, and Vitamin D deficiency and the effect of recovery from iron deficiency on Vitamin D status. The aim of this study was to conduct a systematic search of observational and clinical trials in this field. The databases of PubMed, ProQuest, Cochrane Library, ISI Web of Knowledge, and SCOPUS were searched comprehensively. English-language human studies conducted on iron deficient patients or interventions on the effect of iron therapy on Vitamin D were extracted (n = 10). Our initial search yielded 938 articles. A total of 23 papers met the inclusion criteria. Thirteen studies were excluded because they were not relevant or not defining anemia types. The final analysis was performed on ten articles (3 cross-sectional and 7 interventional studies). Observational data indicated a positive relationship between iron status and Vitamin D, while trials did not support the effectiveness of iron supplementation on improving Vitamin D status. The mechanism underlying this association may involve the reduction of the activation of hydroxylases that yield calcitriol. Future randomized controlled trials with large sample sizes and proper designs are needed to highlight underlying mechanisms. |
| first_indexed | 2024-04-13T19:27:10Z |
| format | Article |
| id | doaj.art-c01131836470401892525d13670b9082 |
| institution | Directory Open Access Journal |
| issn | 2008-7802 2008-8213 |
| language | English |
| last_indexed | 2024-04-13T19:27:10Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | International Journal of Preventive Medicine |
| spelling | doaj.art-c01131836470401892525d13670b90822022-12-22T02:33:18ZengWolters Kluwer Medknow PublicationsInternational Journal of Preventive Medicine2008-78022008-82132016-01-017112612610.4103/2008-7802.195212Effects of iron on Vitamin D metabolism: A systematic reviewFatemeh Azizi-SoleimanMohammadreza VafaBehnaz AbiriMorteza SafaviVitamin D is a prohormone nutrient, which is involved in skeletal and extra-skeletal functions. Iron is another essential nutrient that is necessary for the production of red blood cells and oxygen transport. This element plays important roles in enzymatic systems including those required for Vitamin D activation. To the best of our knowledge, there is no exclusive review on the relationship between iron deficiency anemia (IDA), as the most prevalent type of anemia, and Vitamin D deficiency and the effect of recovery from iron deficiency on Vitamin D status. The aim of this study was to conduct a systematic search of observational and clinical trials in this field. The databases of PubMed, ProQuest, Cochrane Library, ISI Web of Knowledge, and SCOPUS were searched comprehensively. English-language human studies conducted on iron deficient patients or interventions on the effect of iron therapy on Vitamin D were extracted (n = 10). Our initial search yielded 938 articles. A total of 23 papers met the inclusion criteria. Thirteen studies were excluded because they were not relevant or not defining anemia types. The final analysis was performed on ten articles (3 cross-sectional and 7 interventional studies). Observational data indicated a positive relationship between iron status and Vitamin D, while trials did not support the effectiveness of iron supplementation on improving Vitamin D status. The mechanism underlying this association may involve the reduction of the activation of hydroxylases that yield calcitriol. Future randomized controlled trials with large sample sizes and proper designs are needed to highlight underlying mechanisms.http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2016;volume=7;issue=1;spage=126;epage=126;aulast=Azizi-SoleimanAnemiaironiron-deficiency anemiaVitamin DVitamin D deficiency |
| spellingShingle | Fatemeh Azizi-Soleiman Mohammadreza Vafa Behnaz Abiri Morteza Safavi Effects of iron on Vitamin D metabolism: A systematic review International Journal of Preventive Medicine Anemia iron iron-deficiency anemia Vitamin D Vitamin D deficiency |
| title | Effects of iron on Vitamin D metabolism: A systematic review |
| title_full | Effects of iron on Vitamin D metabolism: A systematic review |
| title_fullStr | Effects of iron on Vitamin D metabolism: A systematic review |
| title_full_unstemmed | Effects of iron on Vitamin D metabolism: A systematic review |
| title_short | Effects of iron on Vitamin D metabolism: A systematic review |
| title_sort | effects of iron on vitamin d metabolism a systematic review |
| topic | Anemia iron iron-deficiency anemia Vitamin D Vitamin D deficiency |
| url | http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2016;volume=7;issue=1;spage=126;epage=126;aulast=Azizi-Soleiman |
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