| Summary: | Eyelashes, in addition to fulfilling eye-protective functions, generate an aesthetic impact. Latanoprost is a prostaglandin analog, commonly used for the treatment of glaucoma and intraocular hypertension. The side effect reported most often is the stimulation of eyelash growth. The aim of this study was to evaluate the efficacy and safety of latanoprost in inducing eyelash growth and darkening. Thirty healthy volunteers were recruited in a 3-month, randomized, double-blind, placebo-controlled pilot study. A transparent eyelash mascara was used as a vehicle. The placebo group (<i>n</i> = 15) received only the vehicle, and the latanoprost group (<i>n</i> = 15) received the vehicle + 0.005% latanoprost. The participants were asked to apply the latanoprost topically to the eyelashes while avoiding entry into the eye, daily at night. The latanoprost group showed a significant increase in eyelash length and color change, while the placebo group maintained eyelash length and color throughout the study. The intraocular pressures of all the participants were maintained in normal ranges (10–20 mmHg). Topical application of both the placebo and the latanoprost medications was well tolerated; none of the participants withdrew, generated side effects, or developed any ophthalmic pathology. In conclusion, latanoprost is effective and safe to stimulate the growth of eyelashes.
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