Impact of Rehabilitation on Fatigue in Post-COVID-19 Patients: A Systematic Review and Meta-Analysis
The post-COVID-19 syndrome may affect patients after the COVID-19 post-acute phase. In particular, the 69% of patients reported persistent fatigue at the discharge. To date, no clear data are available regarding the most effective rehabilitative approaches for the treatment of this condition. Thus,...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/12/17/8593 |
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| author | Alessandro de Sire Lucrezia Moggio Nicola Marotta Francesco Agostini Anna Tasselli Vera Drago Ferrante Claudio Curci Dario Calafiore Francesco Ferraro Andrea Bernetti Ozden Ozyemisci Taskiran Antonio Ammendolia |
| author_facet | Alessandro de Sire Lucrezia Moggio Nicola Marotta Francesco Agostini Anna Tasselli Vera Drago Ferrante Claudio Curci Dario Calafiore Francesco Ferraro Andrea Bernetti Ozden Ozyemisci Taskiran Antonio Ammendolia |
| author_sort | Alessandro de Sire |
| collection | DOAJ |
| description | The post-COVID-19 syndrome may affect patients after the COVID-19 post-acute phase. In particular, the 69% of patients reported persistent fatigue at the discharge. To date, no clear data are available regarding the most effective rehabilitative approaches for the treatment of this condition. Thus, this systematic review aimed to evaluate the rehabilitation treatment’s efficacy on fatigue in post-COVID-19 patients. We systematically searched PubMed, Scopus, and Web of Science databases to find longitudinal study designs presenting: post-COVID-19 patients as participants; a rehabilitative approach aimed to reduce post-COVID-19 syndrome as intervention; and fatigue intensity assessed through an evaluation tool that quantified the perceived exertion (i.e., fatigue severity scale, FSS; Borg Scale (BS); Borg Category Ratio 10, CR10; Checklist Individual Strength (CIS) fatigue scale; FACIT (Functional Assessment of Chronic Illness Therapy) fatigue scale). The present systematic review protocol was registered on PROSPERO (registration number CRD42021284058). Out of 704 articles, 6 studies were included. Nearly all patients showed COVID-19-related fatigue, and after the rehabilitation treatment, only 17% of subjects reported the persistency of symptoms. The overall effect size reported a −1.40 decrease in Borg Category Ratio 10 with a SE of 0.05 and a 95% CI between −1.50 and −1.30 (<i>p</i> < 0.001). The present systematic review and meta-analysis underlines the rehabilitation role in the fatigue reduction in patients affected by post-COVID-19 syndrome. |
| first_indexed | 2024-03-10T03:03:03Z |
| format | Article |
| id | doaj.art-c0122b5b3201402fa76a38c3252f0238 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T03:03:03Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-c0122b5b3201402fa76a38c3252f02382023-11-23T12:42:18ZengMDPI AGApplied Sciences2076-34172022-08-011217859310.3390/app12178593Impact of Rehabilitation on Fatigue in Post-COVID-19 Patients: A Systematic Review and Meta-AnalysisAlessandro de Sire0Lucrezia Moggio1Nicola Marotta2Francesco Agostini3Anna Tasselli4Vera Drago Ferrante5Claudio Curci6Dario Calafiore7Francesco Ferraro8Andrea Bernetti9Ozden Ozyemisci Taskiran10Antonio Ammendolia11Physical Medicine and Rehabilitation Unit, Department of Medical and Surgical Sciences, University of Catanzaro Magna Graecia, 88100 Catanzaro, ItalyPhysical Medicine and Rehabilitation Unit, Department of Medical and Surgical Sciences, University of Catanzaro Magna Graecia, 88100 Catanzaro, ItalyPhysical Medicine and Rehabilitation Unit, Department of Medical and Surgical Sciences, University of Catanzaro Magna Graecia, 88100 Catanzaro, ItalyDepartment of Anatomy, Histology, Forensic Medicine and Orthopedics, Sapienza University, 00185 Rome, ItalyPhysical Medicine and Rehabilitation Unit, Department of Medical and Surgical Sciences, University of Catanzaro Magna Graecia, 88100 Catanzaro, ItalyPhysical Medicine and Rehabilitation Unit, Department of Medical and Surgical Sciences, University of Catanzaro Magna Graecia, 88100 Catanzaro, ItalyPhysical Medicine and Rehabilitation Unit, Department of Neurosciences, ASST Carlo Poma, 46100 Mantova, ItalyPhysical Medicine and Rehabilitation Unit, Department of Neurosciences, ASST Carlo Poma, 46100 Mantova, ItalyPhysical Medicine and Rehabilitation Unit, Department of Neurosciences, ASST Carlo Poma, 46100 Mantova, ItalyDepartment of Anatomy, Histology, Forensic Medicine and Orthopedics, Sapienza University, 00185 Rome, ItalyDepartment of Physical Medicine and Rehabilitation, Koç University School of Medicine, Istanbul 34450, TurkeyPhysical Medicine and Rehabilitation Unit, Department of Medical and Surgical Sciences, University of Catanzaro Magna Graecia, 88100 Catanzaro, ItalyThe post-COVID-19 syndrome may affect patients after the COVID-19 post-acute phase. In particular, the 69% of patients reported persistent fatigue at the discharge. To date, no clear data are available regarding the most effective rehabilitative approaches for the treatment of this condition. Thus, this systematic review aimed to evaluate the rehabilitation treatment’s efficacy on fatigue in post-COVID-19 patients. We systematically searched PubMed, Scopus, and Web of Science databases to find longitudinal study designs presenting: post-COVID-19 patients as participants; a rehabilitative approach aimed to reduce post-COVID-19 syndrome as intervention; and fatigue intensity assessed through an evaluation tool that quantified the perceived exertion (i.e., fatigue severity scale, FSS; Borg Scale (BS); Borg Category Ratio 10, CR10; Checklist Individual Strength (CIS) fatigue scale; FACIT (Functional Assessment of Chronic Illness Therapy) fatigue scale). The present systematic review protocol was registered on PROSPERO (registration number CRD42021284058). Out of 704 articles, 6 studies were included. Nearly all patients showed COVID-19-related fatigue, and after the rehabilitation treatment, only 17% of subjects reported the persistency of symptoms. The overall effect size reported a −1.40 decrease in Borg Category Ratio 10 with a SE of 0.05 and a 95% CI between −1.50 and −1.30 (<i>p</i> < 0.001). The present systematic review and meta-analysis underlines the rehabilitation role in the fatigue reduction in patients affected by post-COVID-19 syndrome.https://www.mdpi.com/2076-3417/12/17/8593fatigueCOVID-19rehabilitationtelerehabilitationpost-COVID-19long COVID |
| spellingShingle | Alessandro de Sire Lucrezia Moggio Nicola Marotta Francesco Agostini Anna Tasselli Vera Drago Ferrante Claudio Curci Dario Calafiore Francesco Ferraro Andrea Bernetti Ozden Ozyemisci Taskiran Antonio Ammendolia Impact of Rehabilitation on Fatigue in Post-COVID-19 Patients: A Systematic Review and Meta-Analysis Applied Sciences fatigue COVID-19 rehabilitation telerehabilitation post-COVID-19 long COVID |
| title | Impact of Rehabilitation on Fatigue in Post-COVID-19 Patients: A Systematic Review and Meta-Analysis |
| title_full | Impact of Rehabilitation on Fatigue in Post-COVID-19 Patients: A Systematic Review and Meta-Analysis |
| title_fullStr | Impact of Rehabilitation on Fatigue in Post-COVID-19 Patients: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Impact of Rehabilitation on Fatigue in Post-COVID-19 Patients: A Systematic Review and Meta-Analysis |
| title_short | Impact of Rehabilitation on Fatigue in Post-COVID-19 Patients: A Systematic Review and Meta-Analysis |
| title_sort | impact of rehabilitation on fatigue in post covid 19 patients a systematic review and meta analysis |
| topic | fatigue COVID-19 rehabilitation telerehabilitation post-COVID-19 long COVID |
| url | https://www.mdpi.com/2076-3417/12/17/8593 |
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