Longitudinal analysis of quality of life in primary lung cancer patients with chlamydia pneumoniae infection: a time-to-deterioration model
Abstract Background Chlamydia pneumoniae (Cpn) IgG and IgA has been strongly linked to lung cancer, but its impact on patients' quality of life remains unclear. Our objective was to investigate the relationship between pre-treatment Cpn IgG and IgA and time to deterioration (TTD) of the HRQoL i...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-01-01
|
| Series: | BMC Pulmonary Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12890-024-02860-x |
| _version_ | 1797350154960896000 |
|---|---|
| author | Zishan Chen Jinman Zhuang Maolin Liu Xinying Xu Yuhang Liu Shuyan Yang Jinbao Xie Nanlong Lin Fancai Lai Fei He |
| author_facet | Zishan Chen Jinman Zhuang Maolin Liu Xinying Xu Yuhang Liu Shuyan Yang Jinbao Xie Nanlong Lin Fancai Lai Fei He |
| author_sort | Zishan Chen |
| collection | DOAJ |
| description | Abstract Background Chlamydia pneumoniae (Cpn) IgG and IgA has been strongly linked to lung cancer, but its impact on patients' quality of life remains unclear. Our objective was to investigate the relationship between pre-treatment Cpn IgG and IgA and time to deterioration (TTD) of the HRQoL in patients with primary lung cancer. Methods A prospective hospital-based study was conducted from June 2017 to December 2018, enrolling 82 patients with primary lung cancer admitted to the First Affiliated Hospital of Fujian Medical University for questionnaire surveys. Cpn IgG and IgA was detected by microimmunofluorescence method. HRQoL was assessed at baseline and during follow-up using the EORTC Quality of Life Questionnaire version 3.0 (EORTC QLQ-C30) and EORTC Quality of Life Questionnaire-Lung Cancer (EORTC QLQ-LC13). HRQoL scores were calculated using the QoLR package, and TTD events were determined (minimum clinically significant difference = 5 points). Cox regression analysis was used to evaluate the effect of Cpn IgG and IgA on HRQoL. Results We investigated the relationship between Cpn IgG and IgA and quality of life in patients with primary lung cancer. The study was found that 75.61% of cases were Cpn IgG + and 45.12% were Cpn IgA + . Cpn IgA + IgG + was 41.46%. For EORTC QLQ-C30, Physical function (PF) and Pain (PA) TTD events on the functional scale and Symptom scale were the most common during follow-up. After adjusting for gender and smoking status, Pre-treatment Cpn IgA + was found to signifcantly delay TTD of Physical functioning(HR = 0.539, 95% CI: 0.291–0.996, P = 0.048). In addition, Cpn IgG + before treatment significantly delayed TTD in Emotional functioning (HR = 0.310, 95% CI: 0.115–0.836, P = 0.021). For EORTC QLQ-LC13, deterioration of dyspnea (LC-DY) was the most common event. However, Cpn IgG and IgA before treatment had no effect on the TTD of EORTC QLQ-LC13 items. Conclusions According to EORTC QLQ-C30 and EORTC QLQ-LC13, Cpn IgA delayed TTD in Physical functioning and Cpn IgG delayed TTD in Emotional functioning. |
| first_indexed | 2024-03-08T12:40:42Z |
| format | Article |
| id | doaj.art-c0149ecbebe04fd486d696112a049183 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-03-08T12:40:42Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-c0149ecbebe04fd486d696112a0491832024-01-21T12:08:47ZengBMCBMC Pulmonary Medicine1471-24662024-01-0124111210.1186/s12890-024-02860-xLongitudinal analysis of quality of life in primary lung cancer patients with chlamydia pneumoniae infection: a time-to-deterioration modelZishan Chen0Jinman Zhuang1Maolin Liu2Xinying Xu3Yuhang Liu4Shuyan Yang5Jinbao Xie6Nanlong Lin7Fancai Lai8Fei He9Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and CancerSchool of Public Health, Fujian Medical UniversityDepartment of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and CancerSchool of Public Health, Fujian Medical UniversityDepartment of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and CancerSchool of Public Health, Fujian Medical UniversityDepartment of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and CancerSchool of Public Health, Fujian Medical UniversityDepartment of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and CancerSchool of Public Health, Fujian Medical UniversityDepartment of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and CancerSchool of Public Health, Fujian Medical UniversityDepartment of Thoracic Surgery, the First Affiliated Hospital of Fujian Medical UniversityDepartment of Thoracic Surgery, the First Affiliated Hospital of Fujian Medical UniversityDepartment of Thoracic Surgery, the First Affiliated Hospital of Fujian Medical UniversityDepartment of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and CancerSchool of Public Health, Fujian Medical UniversityAbstract Background Chlamydia pneumoniae (Cpn) IgG and IgA has been strongly linked to lung cancer, but its impact on patients' quality of life remains unclear. Our objective was to investigate the relationship between pre-treatment Cpn IgG and IgA and time to deterioration (TTD) of the HRQoL in patients with primary lung cancer. Methods A prospective hospital-based study was conducted from June 2017 to December 2018, enrolling 82 patients with primary lung cancer admitted to the First Affiliated Hospital of Fujian Medical University for questionnaire surveys. Cpn IgG and IgA was detected by microimmunofluorescence method. HRQoL was assessed at baseline and during follow-up using the EORTC Quality of Life Questionnaire version 3.0 (EORTC QLQ-C30) and EORTC Quality of Life Questionnaire-Lung Cancer (EORTC QLQ-LC13). HRQoL scores were calculated using the QoLR package, and TTD events were determined (minimum clinically significant difference = 5 points). Cox regression analysis was used to evaluate the effect of Cpn IgG and IgA on HRQoL. Results We investigated the relationship between Cpn IgG and IgA and quality of life in patients with primary lung cancer. The study was found that 75.61% of cases were Cpn IgG + and 45.12% were Cpn IgA + . Cpn IgA + IgG + was 41.46%. For EORTC QLQ-C30, Physical function (PF) and Pain (PA) TTD events on the functional scale and Symptom scale were the most common during follow-up. After adjusting for gender and smoking status, Pre-treatment Cpn IgA + was found to signifcantly delay TTD of Physical functioning(HR = 0.539, 95% CI: 0.291–0.996, P = 0.048). In addition, Cpn IgG + before treatment significantly delayed TTD in Emotional functioning (HR = 0.310, 95% CI: 0.115–0.836, P = 0.021). For EORTC QLQ-LC13, deterioration of dyspnea (LC-DY) was the most common event. However, Cpn IgG and IgA before treatment had no effect on the TTD of EORTC QLQ-LC13 items. Conclusions According to EORTC QLQ-C30 and EORTC QLQ-LC13, Cpn IgA delayed TTD in Physical functioning and Cpn IgG delayed TTD in Emotional functioning.https://doi.org/10.1186/s12890-024-02860-xPrimary lung cancerChlamydia pneumoniaHealth-related quality of lifeTime to deterioration |
| spellingShingle | Zishan Chen Jinman Zhuang Maolin Liu Xinying Xu Yuhang Liu Shuyan Yang Jinbao Xie Nanlong Lin Fancai Lai Fei He Longitudinal analysis of quality of life in primary lung cancer patients with chlamydia pneumoniae infection: a time-to-deterioration model BMC Pulmonary Medicine Primary lung cancer Chlamydia pneumonia Health-related quality of life Time to deterioration |
| title | Longitudinal analysis of quality of life in primary lung cancer patients with chlamydia pneumoniae infection: a time-to-deterioration model |
| title_full | Longitudinal analysis of quality of life in primary lung cancer patients with chlamydia pneumoniae infection: a time-to-deterioration model |
| title_fullStr | Longitudinal analysis of quality of life in primary lung cancer patients with chlamydia pneumoniae infection: a time-to-deterioration model |
| title_full_unstemmed | Longitudinal analysis of quality of life in primary lung cancer patients with chlamydia pneumoniae infection: a time-to-deterioration model |
| title_short | Longitudinal analysis of quality of life in primary lung cancer patients with chlamydia pneumoniae infection: a time-to-deterioration model |
| title_sort | longitudinal analysis of quality of life in primary lung cancer patients with chlamydia pneumoniae infection a time to deterioration model |
| topic | Primary lung cancer Chlamydia pneumonia Health-related quality of life Time to deterioration |
| url | https://doi.org/10.1186/s12890-024-02860-x |
| work_keys_str_mv | AT zishanchen longitudinalanalysisofqualityoflifeinprimarylungcancerpatientswithchlamydiapneumoniaeinfectionatimetodeteriorationmodel AT jinmanzhuang longitudinalanalysisofqualityoflifeinprimarylungcancerpatientswithchlamydiapneumoniaeinfectionatimetodeteriorationmodel AT maolinliu longitudinalanalysisofqualityoflifeinprimarylungcancerpatientswithchlamydiapneumoniaeinfectionatimetodeteriorationmodel AT xinyingxu longitudinalanalysisofqualityoflifeinprimarylungcancerpatientswithchlamydiapneumoniaeinfectionatimetodeteriorationmodel AT yuhangliu longitudinalanalysisofqualityoflifeinprimarylungcancerpatientswithchlamydiapneumoniaeinfectionatimetodeteriorationmodel AT shuyanyang longitudinalanalysisofqualityoflifeinprimarylungcancerpatientswithchlamydiapneumoniaeinfectionatimetodeteriorationmodel AT jinbaoxie longitudinalanalysisofqualityoflifeinprimarylungcancerpatientswithchlamydiapneumoniaeinfectionatimetodeteriorationmodel AT nanlonglin longitudinalanalysisofqualityoflifeinprimarylungcancerpatientswithchlamydiapneumoniaeinfectionatimetodeteriorationmodel AT fancailai longitudinalanalysisofqualityoflifeinprimarylungcancerpatientswithchlamydiapneumoniaeinfectionatimetodeteriorationmodel AT feihe longitudinalanalysisofqualityoflifeinprimarylungcancerpatientswithchlamydiapneumoniaeinfectionatimetodeteriorationmodel |