The association between PTPN22 C1858T gene polymorphism and type 1 diabetes mellitus: an Indonesian study
AbstractBackground Type 1 diabetes mellitus (T1DM) is disease caused by the destruction of β pancreatic cells. The activation of T-lymphocyte and proliferation inhibitor are induced by protein tyrosine phosphatase non-receptor type 22 (PTPN22). However, the link between PTPN22 C1858T gene polymorphi...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
|
| Series: | Annals of Medicine |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2023.2190162 |
| _version_ | 1797353762445066240 |
|---|---|
| author | Nur Rochmah Fatimah Arief Muhammad Faizi Sukmawati Basuki |
| author_facet | Nur Rochmah Fatimah Arief Muhammad Faizi Sukmawati Basuki |
| author_sort | Nur Rochmah |
| collection | DOAJ |
| description | AbstractBackground Type 1 diabetes mellitus (T1DM) is disease caused by the destruction of β pancreatic cells. The activation of T-lymphocyte and proliferation inhibitor are induced by protein tyrosine phosphatase non-receptor type 22 (PTPN22). However, the link between PTPN22 C1858T gene polymorphism and T1DM is still controversy. This study aimed to analyse the C1858T gene polymorphism in Indonesian children with T1DM.Materials and methods This case-control study was conducted from March 2021 to May 2022 in the Endocrinology Outpatient Clinic at Dr. Soetomo Hospital and Tropical Disease Center Universitas Airlangga. Patients with controlled T1DM during the study period were included. The PTPN22 analysis used polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method.Results Sixty-two children voluntarily participated in this study, and were equally divided into the T1DM and control groups. Most of the patients (94%, 58/62) are Javanese. This study revealed a more frequent CC genotype (9.4%) and allele-C (54.6%) polymorphism in the T1DM group, while more frequent CT genotype (100%) and allele-T (50%) polymorphism were in the control group. The C- and T-allele frequency was 54.6% and 45.4% in the T1DM group, respectively. The T1DM and control groups did not significantly differ (p= .2381).Conclusions PTPN22 homozygous genotype-CC and allele-C polymorphisms are more frequent in patients with T1DM. However, the PTPN22 C1858T gene polymorphism did not significantly correlate to T1DM children in this study.Key Messages:The PTPN22 C1858T gene polymorphism does not significantly affect the susceptibility of T1DM in Indonesian children.PTPN22 homozygous genotype-CC polymorphism was more observed in the T1DM group; thus, this genotype may play as a risk factor for T1DM children in the Indonesian population. |
| first_indexed | 2024-03-08T13:34:39Z |
| format | Article |
| id | doaj.art-c01779b7f8fb4ea1a36797feb3f6979e |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-03-08T13:34:39Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-c01779b7f8fb4ea1a36797feb3f6979e2024-01-16T19:13:22ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602023-12-015511211121510.1080/07853890.2023.2190162The association between PTPN22 C1858T gene polymorphism and type 1 diabetes mellitus: an Indonesian studyNur Rochmah0Fatimah Arief1Muhammad Faizi2Sukmawati Basuki3Department of Child Health, Faculty of Medicine, Dr. Soetomo General Hospital, Universitas Airlangga, Surabaya, IndonesiaDepartment of Child Health, Faculty of Medicine, Dr. Soetomo General Hospital, Universitas Airlangga, Surabaya, IndonesiaDepartment of Child Health, Faculty of Medicine, Dr. Soetomo General Hospital, Universitas Airlangga, Surabaya, IndonesiaInstitute of Tropical Disease, Universitas Airlangga, Surabaya, IndonesiaAbstractBackground Type 1 diabetes mellitus (T1DM) is disease caused by the destruction of β pancreatic cells. The activation of T-lymphocyte and proliferation inhibitor are induced by protein tyrosine phosphatase non-receptor type 22 (PTPN22). However, the link between PTPN22 C1858T gene polymorphism and T1DM is still controversy. This study aimed to analyse the C1858T gene polymorphism in Indonesian children with T1DM.Materials and methods This case-control study was conducted from March 2021 to May 2022 in the Endocrinology Outpatient Clinic at Dr. Soetomo Hospital and Tropical Disease Center Universitas Airlangga. Patients with controlled T1DM during the study period were included. The PTPN22 analysis used polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method.Results Sixty-two children voluntarily participated in this study, and were equally divided into the T1DM and control groups. Most of the patients (94%, 58/62) are Javanese. This study revealed a more frequent CC genotype (9.4%) and allele-C (54.6%) polymorphism in the T1DM group, while more frequent CT genotype (100%) and allele-T (50%) polymorphism were in the control group. The C- and T-allele frequency was 54.6% and 45.4% in the T1DM group, respectively. The T1DM and control groups did not significantly differ (p= .2381).Conclusions PTPN22 homozygous genotype-CC and allele-C polymorphisms are more frequent in patients with T1DM. However, the PTPN22 C1858T gene polymorphism did not significantly correlate to T1DM children in this study.Key Messages:The PTPN22 C1858T gene polymorphism does not significantly affect the susceptibility of T1DM in Indonesian children.PTPN22 homozygous genotype-CC polymorphism was more observed in the T1DM group; thus, this genotype may play as a risk factor for T1DM children in the Indonesian population.https://www.tandfonline.com/doi/10.1080/07853890.2023.2190162Type 1 diabetes mellitusPTPN22children |
| spellingShingle | Nur Rochmah Fatimah Arief Muhammad Faizi Sukmawati Basuki The association between PTPN22 C1858T gene polymorphism and type 1 diabetes mellitus: an Indonesian study Annals of Medicine Type 1 diabetes mellitus PTPN22 children |
| title | The association between PTPN22 C1858T gene polymorphism and type 1 diabetes mellitus: an Indonesian study |
| title_full | The association between PTPN22 C1858T gene polymorphism and type 1 diabetes mellitus: an Indonesian study |
| title_fullStr | The association between PTPN22 C1858T gene polymorphism and type 1 diabetes mellitus: an Indonesian study |
| title_full_unstemmed | The association between PTPN22 C1858T gene polymorphism and type 1 diabetes mellitus: an Indonesian study |
| title_short | The association between PTPN22 C1858T gene polymorphism and type 1 diabetes mellitus: an Indonesian study |
| title_sort | association between ptpn22 c1858t gene polymorphism and type 1 diabetes mellitus an indonesian study |
| topic | Type 1 diabetes mellitus PTPN22 children |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2023.2190162 |
| work_keys_str_mv | AT nurrochmah theassociationbetweenptpn22c1858tgenepolymorphismandtype1diabetesmellitusanindonesianstudy AT fatimaharief theassociationbetweenptpn22c1858tgenepolymorphismandtype1diabetesmellitusanindonesianstudy AT muhammadfaizi theassociationbetweenptpn22c1858tgenepolymorphismandtype1diabetesmellitusanindonesianstudy AT sukmawatibasuki theassociationbetweenptpn22c1858tgenepolymorphismandtype1diabetesmellitusanindonesianstudy AT nurrochmah associationbetweenptpn22c1858tgenepolymorphismandtype1diabetesmellitusanindonesianstudy AT fatimaharief associationbetweenptpn22c1858tgenepolymorphismandtype1diabetesmellitusanindonesianstudy AT muhammadfaizi associationbetweenptpn22c1858tgenepolymorphismandtype1diabetesmellitusanindonesianstudy AT sukmawatibasuki associationbetweenptpn22c1858tgenepolymorphismandtype1diabetesmellitusanindonesianstudy |