Tetrahedral DNA nanostructures for effective treatment of cancer: advances and prospects
Abstract Recently, DNA nanostructures with vast application potential in the field of biomedicine, especially in drug delivery. Among these, tetrahedral DNA nanostructures (TDN) have attracted interest worldwide due to their high stability, excellent biocompatibility, and simplicity of modification....
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-12-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-021-01164-0 |
| _version_ | 1828281890565521408 |
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| author | Jianqin Yan Xiaohui Zhan Zhuangzhuang Zhang Keqi Chen Maolong Wang Yong Sun Bin He Yan Liang |
| author_facet | Jianqin Yan Xiaohui Zhan Zhuangzhuang Zhang Keqi Chen Maolong Wang Yong Sun Bin He Yan Liang |
| author_sort | Jianqin Yan |
| collection | DOAJ |
| description | Abstract Recently, DNA nanostructures with vast application potential in the field of biomedicine, especially in drug delivery. Among these, tetrahedral DNA nanostructures (TDN) have attracted interest worldwide due to their high stability, excellent biocompatibility, and simplicity of modification. TDN could be synthesized easily and reproducibly to serve as carriers for, chemotherapeutic drugs, nucleic acid drugs and imaging probes. Therefore, their applications include, but are not restricted to, drug delivery, molecular diagnostics, and biological imaging. In this review, we summarize the methods of functional modification and application of TDN in cancer treatment. Also, we discuss the pressing questions that should be targeted to increase the applicability of TDN in the future. Graphical Abstract |
| first_indexed | 2024-04-13T08:22:48Z |
| format | Article |
| id | doaj.art-c019849356f2424a84240706996dc73a |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-13T08:22:48Z |
| publishDate | 2021-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-c019849356f2424a84240706996dc73a2022-12-22T02:54:36ZengBMCJournal of Nanobiotechnology1477-31552021-12-0119111610.1186/s12951-021-01164-0Tetrahedral DNA nanostructures for effective treatment of cancer: advances and prospectsJianqin Yan0Xiaohui Zhan1Zhuangzhuang Zhang2Keqi Chen3Maolong Wang4Yong Sun5Bin He6Yan Liang7Department of Pharmaceutics, School of Pharmacy, Qingdao UniversityNational Engineering Research Center for Biomaterials, Sichuan UniversityNational Engineering Research Center for Biomaterials, Sichuan UniversityDepartment of Clinical Laboratory, Qingdao Special Servicemen Recuperation Centre of PLA NavyDepartment of Thoracic Surgery, Affiliated Hospital of Qingdao UniversityDepartment of Pharmaceutics, School of Pharmacy, Qingdao UniversityNational Engineering Research Center for Biomaterials, Sichuan UniversityDepartment of Pharmaceutics, School of Pharmacy, Qingdao UniversityAbstract Recently, DNA nanostructures with vast application potential in the field of biomedicine, especially in drug delivery. Among these, tetrahedral DNA nanostructures (TDN) have attracted interest worldwide due to their high stability, excellent biocompatibility, and simplicity of modification. TDN could be synthesized easily and reproducibly to serve as carriers for, chemotherapeutic drugs, nucleic acid drugs and imaging probes. Therefore, their applications include, but are not restricted to, drug delivery, molecular diagnostics, and biological imaging. In this review, we summarize the methods of functional modification and application of TDN in cancer treatment. Also, we discuss the pressing questions that should be targeted to increase the applicability of TDN in the future. Graphical Abstracthttps://doi.org/10.1186/s12951-021-01164-0Tetrahedral DNA nanostructuresFunctionalized modificationIntellectualizationDrug deliveryTumor treatment |
| spellingShingle | Jianqin Yan Xiaohui Zhan Zhuangzhuang Zhang Keqi Chen Maolong Wang Yong Sun Bin He Yan Liang Tetrahedral DNA nanostructures for effective treatment of cancer: advances and prospects Journal of Nanobiotechnology Tetrahedral DNA nanostructures Functionalized modification Intellectualization Drug delivery Tumor treatment |
| title | Tetrahedral DNA nanostructures for effective treatment of cancer: advances and prospects |
| title_full | Tetrahedral DNA nanostructures for effective treatment of cancer: advances and prospects |
| title_fullStr | Tetrahedral DNA nanostructures for effective treatment of cancer: advances and prospects |
| title_full_unstemmed | Tetrahedral DNA nanostructures for effective treatment of cancer: advances and prospects |
| title_short | Tetrahedral DNA nanostructures for effective treatment of cancer: advances and prospects |
| title_sort | tetrahedral dna nanostructures for effective treatment of cancer advances and prospects |
| topic | Tetrahedral DNA nanostructures Functionalized modification Intellectualization Drug delivery Tumor treatment |
| url | https://doi.org/10.1186/s12951-021-01164-0 |
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