Emerging Role of Cancer-Associated Fibroblasts-Derived Exosomes in Tumorigenesis
Cancer-associated fibroblasts (CAFs) are the most important component of the stromal cell population in the tumor microenvironment and play an irreplaceable role in oncogenesis and cancer progression. Exosomes, a class of small extracellular vesicles, can transfer biological information (e.g., prote...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.795372/full |
| _version_ | 1819282856603549696 |
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| author | Lushan Peng Dan Wang Yingying Han Tao Huang Xiaoyun He Junpu Wang Junpu Wang Junpu Wang Chunlin Ou Chunlin Ou |
| author_facet | Lushan Peng Dan Wang Yingying Han Tao Huang Xiaoyun He Junpu Wang Junpu Wang Junpu Wang Chunlin Ou Chunlin Ou |
| author_sort | Lushan Peng |
| collection | DOAJ |
| description | Cancer-associated fibroblasts (CAFs) are the most important component of the stromal cell population in the tumor microenvironment and play an irreplaceable role in oncogenesis and cancer progression. Exosomes, a class of small extracellular vesicles, can transfer biological information (e.g., proteins, nucleic acids, and metabolites as messengers) from secreting cells to target recipient cells, thereby affecting the progression of human diseases, including cancers. Recent studies revealed that CAF-derived exosomes play a crucial part in tumorigenesis, tumor cell proliferation, metastasis, drug resistance, and the immune response. Moreover, aberrant expression of CAF-derived exosomal noncoding RNAs and proteins strongly correlates with clinical pathological characterizations of cancer patients. Gaining deeper insight into the participation of CAF-derived exosomes in tumorigenesis may lead to novel diagnostic biomarkers and therapeutic targets in human cancers. |
| first_indexed | 2024-12-24T01:22:14Z |
| format | Article |
| id | doaj.art-c01cc78cabde4141b388e8c55fd6fd8a |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-24T01:22:14Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-c01cc78cabde4141b388e8c55fd6fd8a2022-12-21T17:22:38ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-01-011210.3389/fimmu.2021.795372795372Emerging Role of Cancer-Associated Fibroblasts-Derived Exosomes in TumorigenesisLushan Peng0Dan Wang1Yingying Han2Tao Huang3Xiaoyun He4Junpu Wang5Junpu Wang6Junpu Wang7Chunlin Ou8Chunlin Ou9Department of Pathology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Pathology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Pathology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Pathology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Ultrasound Imaging, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Pathology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Pathology, School of Basic Medicine, Central South University, Changsha, ChinaKey Laboratory of Hunan Province in Neurodegenerative Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Pathology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaCancer-associated fibroblasts (CAFs) are the most important component of the stromal cell population in the tumor microenvironment and play an irreplaceable role in oncogenesis and cancer progression. Exosomes, a class of small extracellular vesicles, can transfer biological information (e.g., proteins, nucleic acids, and metabolites as messengers) from secreting cells to target recipient cells, thereby affecting the progression of human diseases, including cancers. Recent studies revealed that CAF-derived exosomes play a crucial part in tumorigenesis, tumor cell proliferation, metastasis, drug resistance, and the immune response. Moreover, aberrant expression of CAF-derived exosomal noncoding RNAs and proteins strongly correlates with clinical pathological characterizations of cancer patients. Gaining deeper insight into the participation of CAF-derived exosomes in tumorigenesis may lead to novel diagnostic biomarkers and therapeutic targets in human cancers.https://www.frontiersin.org/articles/10.3389/fimmu.2021.795372/fullcancer-associated fibroblastsexosomesmetastasisimmune responsebiomarkerstherapy |
| spellingShingle | Lushan Peng Dan Wang Yingying Han Tao Huang Xiaoyun He Junpu Wang Junpu Wang Junpu Wang Chunlin Ou Chunlin Ou Emerging Role of Cancer-Associated Fibroblasts-Derived Exosomes in Tumorigenesis Frontiers in Immunology cancer-associated fibroblasts exosomes metastasis immune response biomarkers therapy |
| title | Emerging Role of Cancer-Associated Fibroblasts-Derived Exosomes in Tumorigenesis |
| title_full | Emerging Role of Cancer-Associated Fibroblasts-Derived Exosomes in Tumorigenesis |
| title_fullStr | Emerging Role of Cancer-Associated Fibroblasts-Derived Exosomes in Tumorigenesis |
| title_full_unstemmed | Emerging Role of Cancer-Associated Fibroblasts-Derived Exosomes in Tumorigenesis |
| title_short | Emerging Role of Cancer-Associated Fibroblasts-Derived Exosomes in Tumorigenesis |
| title_sort | emerging role of cancer associated fibroblasts derived exosomes in tumorigenesis |
| topic | cancer-associated fibroblasts exosomes metastasis immune response biomarkers therapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.795372/full |
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