Intrauterine growth restriction and its impact on intestinal morphophysiology throughout postnatal development in pigs
Abstract Intrauterine growth restriction (IUGR) compromises fetal development, leading to low birth weight, and predisposes to gastrointestinal disorders. Pigs that suffered IUGR present poor postnatal development, resulting in great economic losses to the industry. The small intestine may be involv...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-14683-z |
| _version_ | 1811218229571354624 |
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| author | Thaís Garcia Santos Saffir Dominique Fernandes Stefany Bruna de Oliveira Araújo Fernando Felicioni Thaís de Mérici Domingues e Paula André Lucas Caldeira-Brant Soraia Viana Ferreira Luciana de Paula Naves Stefânia Priscilla de Souza Paulo Henrique Reis Furtado Campos Hélio Chiarini-Garcia Ana Luísa Neves Alvarenga Dias Fernanda Radicchi Campos Lobato de Almeida |
| author_facet | Thaís Garcia Santos Saffir Dominique Fernandes Stefany Bruna de Oliveira Araújo Fernando Felicioni Thaís de Mérici Domingues e Paula André Lucas Caldeira-Brant Soraia Viana Ferreira Luciana de Paula Naves Stefânia Priscilla de Souza Paulo Henrique Reis Furtado Campos Hélio Chiarini-Garcia Ana Luísa Neves Alvarenga Dias Fernanda Radicchi Campos Lobato de Almeida |
| author_sort | Thaís Garcia Santos |
| collection | DOAJ |
| description | Abstract Intrauterine growth restriction (IUGR) compromises fetal development, leading to low birth weight, and predisposes to gastrointestinal disorders. Pigs that suffered IUGR present poor postnatal development, resulting in great economic losses to the industry. The small intestine may be involved with impaired development, but studies investigating this issue are still limited. Thus, the present study aimed to investigate small intestine morphofunctional alterations in IUGR pigs throughout the production phases (birth to 150 days). IUGR pigs presented lower body weight from birth to the finishing phase (P < 0.05). Although histomorphometrical parameters were not affected during the pre-weaning period, their commitment was observed specifically in the duodenum of the IUGR group at older ages (P < 0.05). The most detrimental effects on the small intestine, such as deeper duodenum crypts’ depth, lower villus height:crypt depth ratio and absorptive area, increased apoptosis and lower proliferation of the duodenum epithelium were noticed at 70 days of age (P < 0.05). Additionally, IUGR pigs presented the lowest chymotrypsin and amylase activities at 70 and 150 days of age, respectively (P < 0.05). These findings may contribute to the elucidation of morphofunctional disorders of the small intestine in IUGR pigs throughout the different production phases, suggesting that poor postnatal development may be due to intestinal damage. |
| first_indexed | 2024-04-12T07:07:34Z |
| format | Article |
| id | doaj.art-c01d040718b44014b0cdbb2cba513f82 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T07:07:34Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-c01d040718b44014b0cdbb2cba513f822022-12-22T03:42:45ZengNature PortfolioScientific Reports2045-23222022-07-0112111010.1038/s41598-022-14683-zIntrauterine growth restriction and its impact on intestinal morphophysiology throughout postnatal development in pigsThaís Garcia Santos0Saffir Dominique Fernandes1Stefany Bruna de Oliveira Araújo2Fernando Felicioni3Thaís de Mérici Domingues e Paula4André Lucas Caldeira-Brant5Soraia Viana Ferreira6Luciana de Paula Naves7Stefânia Priscilla de Souza8Paulo Henrique Reis Furtado Campos9Hélio Chiarini-Garcia10Ana Luísa Neves Alvarenga Dias11Fernanda Radicchi Campos Lobato de Almeida12Laboratory of Structural Biology and Reproduction, Department of Morphology, Institute of Biological Sciences, Federal University of Minas GeraisLaboratory of Structural Biology and Reproduction, Department of Morphology, Institute of Biological Sciences, Federal University of Minas GeraisLaboratory of Structural Biology and Reproduction, Department of Morphology, Institute of Biological Sciences, Federal University of Minas GeraisLaboratory of Structural Biology and Reproduction, Department of Morphology, Institute of Biological Sciences, Federal University of Minas GeraisLaboratory of Structural Biology and Reproduction, Department of Morphology, Institute of Biological Sciences, Federal University of Minas GeraisLaboratory of Structural Biology and Reproduction, Department of Morphology, Institute of Biological Sciences, Federal University of Minas GeraisLaboratory of Structural Biology and Reproduction, Department of Morphology, Institute of Biological Sciences, Federal University of Minas GeraisDepartment of Animal Science, Federal University of LavrasDepartment of Animal Science, Federal University of LavrasDepartment of Animal Science, Federal University of ViçosaLaboratory of Structural Biology and Reproduction, Department of Morphology, Institute of Biological Sciences, Federal University of Minas GeraisFederal University of UberlândiaLaboratory of Structural Biology and Reproduction, Department of Morphology, Institute of Biological Sciences, Federal University of Minas GeraisAbstract Intrauterine growth restriction (IUGR) compromises fetal development, leading to low birth weight, and predisposes to gastrointestinal disorders. Pigs that suffered IUGR present poor postnatal development, resulting in great economic losses to the industry. The small intestine may be involved with impaired development, but studies investigating this issue are still limited. Thus, the present study aimed to investigate small intestine morphofunctional alterations in IUGR pigs throughout the production phases (birth to 150 days). IUGR pigs presented lower body weight from birth to the finishing phase (P < 0.05). Although histomorphometrical parameters were not affected during the pre-weaning period, their commitment was observed specifically in the duodenum of the IUGR group at older ages (P < 0.05). The most detrimental effects on the small intestine, such as deeper duodenum crypts’ depth, lower villus height:crypt depth ratio and absorptive area, increased apoptosis and lower proliferation of the duodenum epithelium were noticed at 70 days of age (P < 0.05). Additionally, IUGR pigs presented the lowest chymotrypsin and amylase activities at 70 and 150 days of age, respectively (P < 0.05). These findings may contribute to the elucidation of morphofunctional disorders of the small intestine in IUGR pigs throughout the different production phases, suggesting that poor postnatal development may be due to intestinal damage.https://doi.org/10.1038/s41598-022-14683-z |
| spellingShingle | Thaís Garcia Santos Saffir Dominique Fernandes Stefany Bruna de Oliveira Araújo Fernando Felicioni Thaís de Mérici Domingues e Paula André Lucas Caldeira-Brant Soraia Viana Ferreira Luciana de Paula Naves Stefânia Priscilla de Souza Paulo Henrique Reis Furtado Campos Hélio Chiarini-Garcia Ana Luísa Neves Alvarenga Dias Fernanda Radicchi Campos Lobato de Almeida Intrauterine growth restriction and its impact on intestinal morphophysiology throughout postnatal development in pigs Scientific Reports |
| title | Intrauterine growth restriction and its impact on intestinal morphophysiology throughout postnatal development in pigs |
| title_full | Intrauterine growth restriction and its impact on intestinal morphophysiology throughout postnatal development in pigs |
| title_fullStr | Intrauterine growth restriction and its impact on intestinal morphophysiology throughout postnatal development in pigs |
| title_full_unstemmed | Intrauterine growth restriction and its impact on intestinal morphophysiology throughout postnatal development in pigs |
| title_short | Intrauterine growth restriction and its impact on intestinal morphophysiology throughout postnatal development in pigs |
| title_sort | intrauterine growth restriction and its impact on intestinal morphophysiology throughout postnatal development in pigs |
| url | https://doi.org/10.1038/s41598-022-14683-z |
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