Mapping global epidemiology of thyroid nodules among general population: A systematic review and meta-analysis
IntroductionAn emerging public health issue is brought on by the worldwide increase of thyroid nodules (TNs). The goal of the current study is to determine the global prevalence of TNs among the general population.MethodsWe screened articles published from January 2000 to May 2022. TN prevalence was...
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| Format: | Article |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1029926/full |
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| author | Chunyang Mu Xin Ming Ye Tian Yang Liu Menglin Yao Yinyun Ni Yong Liu Zhihui Li Zhihui Li |
| author_facet | Chunyang Mu Xin Ming Ye Tian Yang Liu Menglin Yao Yinyun Ni Yong Liu Zhihui Li Zhihui Li |
| author_sort | Chunyang Mu |
| collection | DOAJ |
| description | IntroductionAn emerging public health issue is brought on by the worldwide increase of thyroid nodules (TNs). The goal of the current study is to determine the global prevalence of TNs among the general population.MethodsWe screened articles published from January 2000 to May 2022. TN prevalence was calculated with the DerSimonian–Laird random effects model with arcsine transformation.ResultsA total of 20,358 entries were found in our research, and 102 of them met our inclusion criteria. A total of 9,276,178 individuals have been diagnosed as TNs; the overall prevalence was 24.83% (95% CI 21.44–28.55), regardless of the diagnostic techniques. TNs have become more prevalent during 2012–2022 (29.29%) compared with 2000–2011 (21.53%, p = 0.02). In addition, we discovered that women (36.51%) were more likely to have TNs than men (23.47%, p < 0.01). Interestingly, we found that obesity was correlated with the prevalence of TNs. Additionally, age-specific-stratified TN prevalence was found in our results.DiscussionThis meta-analysis shows that, regardless of country development and economic status, TNs are spreading more widely over the world. Our findings showed a strong correlation between rising TN prevalence and older age, female sex, and elevated weight. To stop the TN epidemic from spreading over the world, increased awareness, the understanding of the disease, and quick action are required. |
| first_indexed | 2024-04-11T17:41:25Z |
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| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T17:41:25Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-c01f506cf4c9439fb380c8f2243a22212022-12-22T04:11:29ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-11-011210.3389/fonc.2022.10299261029926Mapping global epidemiology of thyroid nodules among general population: A systematic review and meta-analysisChunyang Mu0Xin Ming1Ye Tian2Yang Liu3Menglin Yao4Yinyun Ni5Yong Liu6Zhihui Li7Zhihui Li8Department of Liver Surgery and Liver Transplantation Center, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Ultrasound, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Ultrasound, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Obstetrics and Gynecology, Second Affiliated Hospital, Chongqing Medical University, Chongqing, ChinaDepartment of Respiratory and Critical Care Medicine, National Clinical Research Center for Geriatrics, Center of Precision Medicine, Precision Medicine Key Laboratory of Sichuan Province, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Respiratory and Critical Care Medicine, National Clinical Research Center for Geriatrics, Center of Precision Medicine, Precision Medicine Key Laboratory of Sichuan Province, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Gastroenterological Surgery, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Thyroid and Parathyroid Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaLaboratory of Thyroid and Parathyroid Diseases, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaIntroductionAn emerging public health issue is brought on by the worldwide increase of thyroid nodules (TNs). The goal of the current study is to determine the global prevalence of TNs among the general population.MethodsWe screened articles published from January 2000 to May 2022. TN prevalence was calculated with the DerSimonian–Laird random effects model with arcsine transformation.ResultsA total of 20,358 entries were found in our research, and 102 of them met our inclusion criteria. A total of 9,276,178 individuals have been diagnosed as TNs; the overall prevalence was 24.83% (95% CI 21.44–28.55), regardless of the diagnostic techniques. TNs have become more prevalent during 2012–2022 (29.29%) compared with 2000–2011 (21.53%, p = 0.02). In addition, we discovered that women (36.51%) were more likely to have TNs than men (23.47%, p < 0.01). Interestingly, we found that obesity was correlated with the prevalence of TNs. Additionally, age-specific-stratified TN prevalence was found in our results.DiscussionThis meta-analysis shows that, regardless of country development and economic status, TNs are spreading more widely over the world. Our findings showed a strong correlation between rising TN prevalence and older age, female sex, and elevated weight. To stop the TN epidemic from spreading over the world, increased awareness, the understanding of the disease, and quick action are required.https://www.frontiersin.org/articles/10.3389/fonc.2022.1029926/fullepidemiologythyroid noduleprevalenceUltrasoundAutopsy |
| spellingShingle | Chunyang Mu Xin Ming Ye Tian Yang Liu Menglin Yao Yinyun Ni Yong Liu Zhihui Li Zhihui Li Mapping global epidemiology of thyroid nodules among general population: A systematic review and meta-analysis Frontiers in Oncology epidemiology thyroid nodule prevalence Ultrasound Autopsy |
| title | Mapping global epidemiology of thyroid nodules among general population: A systematic review and meta-analysis |
| title_full | Mapping global epidemiology of thyroid nodules among general population: A systematic review and meta-analysis |
| title_fullStr | Mapping global epidemiology of thyroid nodules among general population: A systematic review and meta-analysis |
| title_full_unstemmed | Mapping global epidemiology of thyroid nodules among general population: A systematic review and meta-analysis |
| title_short | Mapping global epidemiology of thyroid nodules among general population: A systematic review and meta-analysis |
| title_sort | mapping global epidemiology of thyroid nodules among general population a systematic review and meta analysis |
| topic | epidemiology thyroid nodule prevalence Ultrasound Autopsy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1029926/full |
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