Optical Coherence Tomography and Optical Coherence Tomography Angiography in Pediatric Retinal Diseases
Indirect ophthalmoscopy and handheld retinal imaging are the most common and traditional modalities for the evaluation and documentation of the pediatric fundus, especially for pre-verbal children. Optical coherence tomography (OCT) allows for in vivo visualization that resembles histology, and opti...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/8/1461 |
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| author | Chung-Ting Wang Yin-Hsi Chang Gavin S. W. Tan Shu Yen Lee R. V. Paul Chan Wei-Chi Wu Andrew S. H. Tsai |
| author_facet | Chung-Ting Wang Yin-Hsi Chang Gavin S. W. Tan Shu Yen Lee R. V. Paul Chan Wei-Chi Wu Andrew S. H. Tsai |
| author_sort | Chung-Ting Wang |
| collection | DOAJ |
| description | Indirect ophthalmoscopy and handheld retinal imaging are the most common and traditional modalities for the evaluation and documentation of the pediatric fundus, especially for pre-verbal children. Optical coherence tomography (OCT) allows for in vivo visualization that resembles histology, and optical coherence tomography angiography (OCTA) allows for non-invasive depth-resolved imaging of the retinal vasculature. Both OCT and OCTA were extensively used and studied in adults, but not in children. The advent of prototype handheld OCT and OCTA have allowed for detailed imaging in younger infants and even neonates in the neonatal care intensive unit with retinopathy of prematurity (ROP). In this review, we discuss the use of OCTA and OCTA in various pediatric retinal diseases, including ROP, familial exudative vitreoretinopathy (FEVR), Coats disease and other less common diseases. For example, handheld portable OCT was shown to detect subclinical macular edema and incomplete foveal development in ROP, as well as subretinal exudation and fibrosis in Coats disease. Some challenges in the pediatric age group include the lack of a normative database and the difficulty in image registration for longitudinal comparison. We believe that technological improvements in the use of OCT and OCTA will improve our understanding and care of pediatric retina patients in the future. |
| first_indexed | 2024-03-11T05:06:24Z |
| format | Article |
| id | doaj.art-c01f83858ec1455fb0196794c2084c9e |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T05:06:24Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-c01f83858ec1455fb0196794c2084c9e2023-11-17T18:55:23ZengMDPI AGDiagnostics2075-44182023-04-01138146110.3390/diagnostics13081461Optical Coherence Tomography and Optical Coherence Tomography Angiography in Pediatric Retinal DiseasesChung-Ting Wang0Yin-Hsi Chang1Gavin S. W. Tan2Shu Yen Lee3R. V. Paul Chan4Wei-Chi Wu5Andrew S. H. Tsai6Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan City 333, TaiwanDepartment of Ophthalmology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan City 333, TaiwanSingapore National Eye Centre, Singapore, Singapore 168751, SingaporeSingapore National Eye Centre, Singapore, Singapore 168751, SingaporeDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Illinois Eye and Ear Infirmary, Chicago, IL 60612, USADepartment of Ophthalmology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan City 333, TaiwanSingapore National Eye Centre, Singapore, Singapore 168751, SingaporeIndirect ophthalmoscopy and handheld retinal imaging are the most common and traditional modalities for the evaluation and documentation of the pediatric fundus, especially for pre-verbal children. Optical coherence tomography (OCT) allows for in vivo visualization that resembles histology, and optical coherence tomography angiography (OCTA) allows for non-invasive depth-resolved imaging of the retinal vasculature. Both OCT and OCTA were extensively used and studied in adults, but not in children. The advent of prototype handheld OCT and OCTA have allowed for detailed imaging in younger infants and even neonates in the neonatal care intensive unit with retinopathy of prematurity (ROP). In this review, we discuss the use of OCTA and OCTA in various pediatric retinal diseases, including ROP, familial exudative vitreoretinopathy (FEVR), Coats disease and other less common diseases. For example, handheld portable OCT was shown to detect subclinical macular edema and incomplete foveal development in ROP, as well as subretinal exudation and fibrosis in Coats disease. Some challenges in the pediatric age group include the lack of a normative database and the difficulty in image registration for longitudinal comparison. We believe that technological improvements in the use of OCT and OCTA will improve our understanding and care of pediatric retina patients in the future.https://www.mdpi.com/2075-4418/13/8/1461optical coherence tomographyoptical coherence tomography angiographypediatric retinaretinopathy of prematurity |
| spellingShingle | Chung-Ting Wang Yin-Hsi Chang Gavin S. W. Tan Shu Yen Lee R. V. Paul Chan Wei-Chi Wu Andrew S. H. Tsai Optical Coherence Tomography and Optical Coherence Tomography Angiography in Pediatric Retinal Diseases Diagnostics optical coherence tomography optical coherence tomography angiography pediatric retina retinopathy of prematurity |
| title | Optical Coherence Tomography and Optical Coherence Tomography Angiography in Pediatric Retinal Diseases |
| title_full | Optical Coherence Tomography and Optical Coherence Tomography Angiography in Pediatric Retinal Diseases |
| title_fullStr | Optical Coherence Tomography and Optical Coherence Tomography Angiography in Pediatric Retinal Diseases |
| title_full_unstemmed | Optical Coherence Tomography and Optical Coherence Tomography Angiography in Pediatric Retinal Diseases |
| title_short | Optical Coherence Tomography and Optical Coherence Tomography Angiography in Pediatric Retinal Diseases |
| title_sort | optical coherence tomography and optical coherence tomography angiography in pediatric retinal diseases |
| topic | optical coherence tomography optical coherence tomography angiography pediatric retina retinopathy of prematurity |
| url | https://www.mdpi.com/2075-4418/13/8/1461 |
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