The prognostic value of left ventricular global peak systolic longitudinal strain in chronic peritoneal dialysis patients
Background: Although left ventricular (LV) global systolic longitudinal strain (GLS) reliably and accurately assesses LV systolic function and is also a powerful prognostic predictor, the importance and prognostic value of GLS in end-stage renal disease patients receiving maintenance peritoneal dial...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2014-12-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906714000840 |
| _version_ | 1819293639796326400 |
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| author | Yen-Wen Liu Chin-Chung Tseng Chi-Ting Su Yu-Tzu Chang Ju-Yi Chen Li-Yin Chen Liang-Miin Tsai Jyh-Hong Chen Ming-Cheng Wang Wei-Chuan Tsai |
| author_facet | Yen-Wen Liu Chin-Chung Tseng Chi-Ting Su Yu-Tzu Chang Ju-Yi Chen Li-Yin Chen Liang-Miin Tsai Jyh-Hong Chen Ming-Cheng Wang Wei-Chuan Tsai |
| author_sort | Yen-Wen Liu |
| collection | DOAJ |
| description | Background: Although left ventricular (LV) global systolic longitudinal strain (GLS) reliably and accurately assesses LV systolic function and is also a powerful prognostic predictor, the importance and prognostic value of GLS in end-stage renal disease patients receiving maintenance peritoneal dialysis (PD) remain unclear. This study sought to determine the prognostic value of GLS in chronic PD patients.
Methods: This prospective study collected clinical and echocardiographic data from 106 stable PD patients (50.0 ± 13.9 years, 45% male) in a dialysis unit of a university hospital. These patients were enrolled from April 2010 to June 2010 and followed until August 2013 (follow-up duration 30.3 ± 14.3 months). The primary outcomes were the presence of major adverse events (MAEs), defined as all-cause mortality, and major adverse cardiovascular cerebral events (MACCEs), i.e. cardiovascular death, cardiac hospitalization, and stroke.
Results: Twenty-nine patients (27%) reported a primary outcome. Patients with MAEs had worse LV systolic function (MAEs vs. no MAEs, −14.8 ± 2.8 vs. −17.1 ± 2.5%, p = 0.003). Using multivariate Cox regression analyses, being male, having a history of heart failure, diabetes mellitus, an increased pulse pressure (≥60 mm Hg), and GLS ≥ −15% were independent predictors of MAEs. The independent risk factors of MACCEs were a history of diabetes mellitus, an increased pulse pressure, and GLS ≥ −15%. After comparison of the overall log likelihood χ2 of the predictive power, GLS was found to add prognostic information to a model based on traditional risk factors.
Conclusion: GLS ≥ −15% provided additional prognostic information that allowed for the early identification of high-risk PD patients. |
| first_indexed | 2024-12-24T04:13:38Z |
| format | Article |
| id | doaj.art-c02509c8ee7f4542a069da3724fa302c |
| institution | Directory Open Access Journal |
| issn | 2352-9067 |
| language | English |
| last_indexed | 2024-12-24T04:13:38Z |
| publishDate | 2014-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj.art-c02509c8ee7f4542a069da3724fa302c2022-12-21T17:16:01ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672014-12-015C1810.1016/j.ijcha.2014.10.016The prognostic value of left ventricular global peak systolic longitudinal strain in chronic peritoneal dialysis patientsYen-Wen Liu0Chin-Chung Tseng1Chi-Ting Su2Yu-Tzu Chang3Ju-Yi Chen4Li-Yin Chen5Liang-Miin Tsai6Jyh-Hong Chen7Ming-Cheng Wang8Wei-Chuan Tsai9Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanDivision of Nephrology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USADivision of Nephrology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanDivision of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanDivision of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanDivision of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanDivision of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanDivision of Nephrology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanDivision of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanBackground: Although left ventricular (LV) global systolic longitudinal strain (GLS) reliably and accurately assesses LV systolic function and is also a powerful prognostic predictor, the importance and prognostic value of GLS in end-stage renal disease patients receiving maintenance peritoneal dialysis (PD) remain unclear. This study sought to determine the prognostic value of GLS in chronic PD patients. Methods: This prospective study collected clinical and echocardiographic data from 106 stable PD patients (50.0 ± 13.9 years, 45% male) in a dialysis unit of a university hospital. These patients were enrolled from April 2010 to June 2010 and followed until August 2013 (follow-up duration 30.3 ± 14.3 months). The primary outcomes were the presence of major adverse events (MAEs), defined as all-cause mortality, and major adverse cardiovascular cerebral events (MACCEs), i.e. cardiovascular death, cardiac hospitalization, and stroke. Results: Twenty-nine patients (27%) reported a primary outcome. Patients with MAEs had worse LV systolic function (MAEs vs. no MAEs, −14.8 ± 2.8 vs. −17.1 ± 2.5%, p = 0.003). Using multivariate Cox regression analyses, being male, having a history of heart failure, diabetes mellitus, an increased pulse pressure (≥60 mm Hg), and GLS ≥ −15% were independent predictors of MAEs. The independent risk factors of MACCEs were a history of diabetes mellitus, an increased pulse pressure, and GLS ≥ −15%. After comparison of the overall log likelihood χ2 of the predictive power, GLS was found to add prognostic information to a model based on traditional risk factors. Conclusion: GLS ≥ −15% provided additional prognostic information that allowed for the early identification of high-risk PD patients.http://www.sciencedirect.com/science/article/pii/S2352906714000840EchocardiographyEnd-stage renal diseasePeritoneal dialysisPrognosis |
| spellingShingle | Yen-Wen Liu Chin-Chung Tseng Chi-Ting Su Yu-Tzu Chang Ju-Yi Chen Li-Yin Chen Liang-Miin Tsai Jyh-Hong Chen Ming-Cheng Wang Wei-Chuan Tsai The prognostic value of left ventricular global peak systolic longitudinal strain in chronic peritoneal dialysis patients International Journal of Cardiology: Heart & Vasculature Echocardiography End-stage renal disease Peritoneal dialysis Prognosis |
| title | The prognostic value of left ventricular global peak systolic longitudinal strain in chronic peritoneal dialysis patients |
| title_full | The prognostic value of left ventricular global peak systolic longitudinal strain in chronic peritoneal dialysis patients |
| title_fullStr | The prognostic value of left ventricular global peak systolic longitudinal strain in chronic peritoneal dialysis patients |
| title_full_unstemmed | The prognostic value of left ventricular global peak systolic longitudinal strain in chronic peritoneal dialysis patients |
| title_short | The prognostic value of left ventricular global peak systolic longitudinal strain in chronic peritoneal dialysis patients |
| title_sort | prognostic value of left ventricular global peak systolic longitudinal strain in chronic peritoneal dialysis patients |
| topic | Echocardiography End-stage renal disease Peritoneal dialysis Prognosis |
| url | http://www.sciencedirect.com/science/article/pii/S2352906714000840 |
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