Dynamic Virulence: Real-Time Assessment of Intracellular Pathogenesis Links <named-content content-type="genus-species">Cryptococcus neoformans</named-content> Phenotype with Clinical Outcome
ABSTRACT While a myriad of studies have examined host factors that predispose persons to infection with the opportunistic fungal pathogen Cryptococcus neoformans, comparatively little has been done to examine how virulence factor differences among cryptococcal isolates may impact outcome. In the rec...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Society for Microbiology
2011-11-01
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| Series: | mBio |
| Online Access: | https://journals.asm.org/doi/10.1128/mBio.00217-11 |
| _version_ | 1818934021699141632 |
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| author | Michael K. Mansour Jatin M. Vyas Stuart M. Levitz |
| author_facet | Michael K. Mansour Jatin M. Vyas Stuart M. Levitz |
| author_sort | Michael K. Mansour |
| collection | DOAJ |
| description | ABSTRACT While a myriad of studies have examined host factors that predispose persons to infection with the opportunistic fungal pathogen Cryptococcus neoformans, comparatively little has been done to examine how virulence factor differences among cryptococcal isolates may impact outcome. In the recent report by Alanio et al. (A. Alanio, M. Desnos-Ollivier, and F. Dromer, mBio 2:e00158-11, 2011), novel flow cytometry-based techniques were employed to demonstrate an association between the phenotype of C. neoformans-macrophage interactions, as measured by phagocytosis and intracellular replication, and patient outcomes, as determined by positive cultures on therapy and survival. These experiments establish that the prognosis of patients with cryptococcosis is influenced by the phenotypic properties of the infecting fungal isolate. |
| first_indexed | 2024-12-20T04:57:39Z |
| format | Article |
| id | doaj.art-c0252fad4e824ab58d9aebc9b2671c54 |
| institution | Directory Open Access Journal |
| issn | 2150-7511 |
| language | English |
| last_indexed | 2024-12-20T04:57:39Z |
| publishDate | 2011-11-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj.art-c0252fad4e824ab58d9aebc9b2671c542022-12-21T19:52:41ZengAmerican Society for MicrobiologymBio2150-75112011-11-012510.1128/mBio.00217-11Dynamic Virulence: Real-Time Assessment of Intracellular Pathogenesis Links <named-content content-type="genus-species">Cryptococcus neoformans</named-content> Phenotype with Clinical OutcomeMichael K. Mansour0Jatin M. Vyas1Stuart M. Levitz2Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USADepartment of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USADepartment of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical Center, Worcester, Massachusetts, USAABSTRACT While a myriad of studies have examined host factors that predispose persons to infection with the opportunistic fungal pathogen Cryptococcus neoformans, comparatively little has been done to examine how virulence factor differences among cryptococcal isolates may impact outcome. In the recent report by Alanio et al. (A. Alanio, M. Desnos-Ollivier, and F. Dromer, mBio 2:e00158-11, 2011), novel flow cytometry-based techniques were employed to demonstrate an association between the phenotype of C. neoformans-macrophage interactions, as measured by phagocytosis and intracellular replication, and patient outcomes, as determined by positive cultures on therapy and survival. These experiments establish that the prognosis of patients with cryptococcosis is influenced by the phenotypic properties of the infecting fungal isolate.https://journals.asm.org/doi/10.1128/mBio.00217-11 |
| spellingShingle | Michael K. Mansour Jatin M. Vyas Stuart M. Levitz Dynamic Virulence: Real-Time Assessment of Intracellular Pathogenesis Links <named-content content-type="genus-species">Cryptococcus neoformans</named-content> Phenotype with Clinical Outcome mBio |
| title | Dynamic Virulence: Real-Time Assessment of Intracellular Pathogenesis Links <named-content content-type="genus-species">Cryptococcus neoformans</named-content> Phenotype with Clinical Outcome |
| title_full | Dynamic Virulence: Real-Time Assessment of Intracellular Pathogenesis Links <named-content content-type="genus-species">Cryptococcus neoformans</named-content> Phenotype with Clinical Outcome |
| title_fullStr | Dynamic Virulence: Real-Time Assessment of Intracellular Pathogenesis Links <named-content content-type="genus-species">Cryptococcus neoformans</named-content> Phenotype with Clinical Outcome |
| title_full_unstemmed | Dynamic Virulence: Real-Time Assessment of Intracellular Pathogenesis Links <named-content content-type="genus-species">Cryptococcus neoformans</named-content> Phenotype with Clinical Outcome |
| title_short | Dynamic Virulence: Real-Time Assessment of Intracellular Pathogenesis Links <named-content content-type="genus-species">Cryptococcus neoformans</named-content> Phenotype with Clinical Outcome |
| title_sort | dynamic virulence real time assessment of intracellular pathogenesis links named content content type genus species cryptococcus neoformans named content phenotype with clinical outcome |
| url | https://journals.asm.org/doi/10.1128/mBio.00217-11 |
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