Association of autoimmune thyroiditis with latent autoimmune diabetes of adults (LADA): A study from North India
Objective: The aim of this work was to study the association of autoimmune thyroiditis (AIT) in the patients of latent autoimmune diabetes of adult (LADA). Materials and Methods: The subjects included were more than 30 years of age, presenting with the deranged glycemic profile. After GAD65 autoanti...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Journal of Diabetology |
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| Online Access: | http://www.journalofdiabetology.org/article.asp?issn=2078-7685;year=2022;volume=13;issue=2;spage=154;epage=158;aulast=Sangma |
| _version_ | 1811343772388163584 |
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| author | Himalina S Sangma Anshul Singh Anubha Srivastava Ram Siya Singh Vatsala Misra |
| author_facet | Himalina S Sangma Anshul Singh Anubha Srivastava Ram Siya Singh Vatsala Misra |
| author_sort | Himalina S Sangma |
| collection | DOAJ |
| description | Objective: The aim of this work was to study the association of autoimmune thyroiditis (AIT) in the patients of latent autoimmune diabetes of adult (LADA). Materials and Methods: The subjects included were more than 30 years of age, presenting with the deranged glycemic profile. After GAD65 autoantibody testing, they were grouped into LADA positive and LADA negative groups. Simultaneously, a thyroid workup for the presence of AIT was done. Statistical Analysis: The Student’s unpaired t test and chi-square test (χ2 test) were used to test for the significance of the difference in AIT between LADA and type 2 diabetes mellitus (T2DM) subjects as applicable. A value of P < 0.05 was taken as significant. Results: A total of 77 patients were included in the study. The mean age was 48 ± 13 years and M:F ratio was 1:3. A high frequency of AIT was found in the LADA group (80%) when compared to the true T2DM group (35%). Mean values of both anti-thyroid peroxidase antibody (anti-TPO) and anti-thyroglobulin antibody (anti-TG) antibodies were found to be significantly different between LADA and T2DM. Percentage positivity for anti-TPO, anti-TG, as well as combined anti-TPO and anti-TG were also found to be significantly different. Conclusion: Based on the significant association of AIT with LADA found in our study, we recommend all AIT patients to undergo simultaneous screening for LADA for a multimodal treatment. |
| first_indexed | 2024-04-13T19:34:50Z |
| format | Article |
| id | doaj.art-c02794e5cc0b42f289435edf71f193e7 |
| institution | Directory Open Access Journal |
| issn | 2078-7685 |
| language | English |
| last_indexed | 2024-04-13T19:34:50Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Diabetology |
| spelling | doaj.art-c02794e5cc0b42f289435edf71f193e72022-12-22T02:33:04ZengWolters Kluwer Medknow PublicationsJournal of Diabetology2078-76852022-01-0113215415810.4103/jod.jod_121_21Association of autoimmune thyroiditis with latent autoimmune diabetes of adults (LADA): A study from North IndiaHimalina S SangmaAnshul SinghAnubha SrivastavaRam Siya SinghVatsala MisraObjective: The aim of this work was to study the association of autoimmune thyroiditis (AIT) in the patients of latent autoimmune diabetes of adult (LADA). Materials and Methods: The subjects included were more than 30 years of age, presenting with the deranged glycemic profile. After GAD65 autoantibody testing, they were grouped into LADA positive and LADA negative groups. Simultaneously, a thyroid workup for the presence of AIT was done. Statistical Analysis: The Student’s unpaired t test and chi-square test (χ2 test) were used to test for the significance of the difference in AIT between LADA and type 2 diabetes mellitus (T2DM) subjects as applicable. A value of P < 0.05 was taken as significant. Results: A total of 77 patients were included in the study. The mean age was 48 ± 13 years and M:F ratio was 1:3. A high frequency of AIT was found in the LADA group (80%) when compared to the true T2DM group (35%). Mean values of both anti-thyroid peroxidase antibody (anti-TPO) and anti-thyroglobulin antibody (anti-TG) antibodies were found to be significantly different between LADA and T2DM. Percentage positivity for anti-TPO, anti-TG, as well as combined anti-TPO and anti-TG were also found to be significantly different. Conclusion: Based on the significant association of AIT with LADA found in our study, we recommend all AIT patients to undergo simultaneous screening for LADA for a multimodal treatment.http://www.journalofdiabetology.org/article.asp?issn=2078-7685;year=2022;volume=13;issue=2;spage=154;epage=158;aulast=Sangmagad65 positive diabetesslowly evolving immune mediated diabetes of adultsthyroid dysfunctiontype 1.5 diabetes |
| spellingShingle | Himalina S Sangma Anshul Singh Anubha Srivastava Ram Siya Singh Vatsala Misra Association of autoimmune thyroiditis with latent autoimmune diabetes of adults (LADA): A study from North India Journal of Diabetology gad65 positive diabetes slowly evolving immune mediated diabetes of adults thyroid dysfunction type 1.5 diabetes |
| title | Association of autoimmune thyroiditis with latent autoimmune diabetes of adults (LADA): A study from North India |
| title_full | Association of autoimmune thyroiditis with latent autoimmune diabetes of adults (LADA): A study from North India |
| title_fullStr | Association of autoimmune thyroiditis with latent autoimmune diabetes of adults (LADA): A study from North India |
| title_full_unstemmed | Association of autoimmune thyroiditis with latent autoimmune diabetes of adults (LADA): A study from North India |
| title_short | Association of autoimmune thyroiditis with latent autoimmune diabetes of adults (LADA): A study from North India |
| title_sort | association of autoimmune thyroiditis with latent autoimmune diabetes of adults lada a study from north india |
| topic | gad65 positive diabetes slowly evolving immune mediated diabetes of adults thyroid dysfunction type 1.5 diabetes |
| url | http://www.journalofdiabetology.org/article.asp?issn=2078-7685;year=2022;volume=13;issue=2;spage=154;epage=158;aulast=Sangma |
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