Identification of New L-Heptanoylphosphatidyl Inositol Pentakisphosphate Derivatives Targeting the Interaction with HIV-1 Gag by Molecular Modelling Studies

Identification of New L-Heptanoylphosphatidyl Inositol Pentakisphosphate Derivatives Targeting the Interaction with HIV-1 Gag by Molecular Modelling Studies

The HIV-1 Gag protein binds to the host cell membrane and assembles into immature particles. Then, in the course of immature virion budding, activated protease cleaves Gag into its main components: MA, CA, NC, and p6 proteins. The highly basic residues of MA predominantly interact with the acidic he...

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Bibliographic Details
Main Authors: Halilibrahim Ciftci, Belgin Sever, Esra Ayan, Mustafa Can, Hasan DeMirci, Masami Otsuka, Amaç Fatih TuYuN, Hiroshi Tateishi, Mikako Fujita
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Pharmaceuticals
Subjects:
HIV
Gag
MA
PI(4,5)P2
IP6
molecular modelling
Online Access:https://www.mdpi.com/1424-8247/15/10/1255

Internet

https://www.mdpi.com/1424-8247/15/10/1255

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