Radiation-induced angiosarcoma: case report
ABSTRACT Angiosarcoma of the breast accounts for less than 1% of breast tumors. This tumor may be primary or secondary to previous radiation therapy and it is also named “radiogenic angiosarcoma of the breast”, which is still a rare entity with a poor prognosis. So far, there are only 307 cases repo...
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| Format: | Article |
| Language: | English |
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Instituto Israelita de Ensino e Pesquisa Albert Einstein
2020-12-01
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| Series: | Einstein (São Paulo) |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082020000100518&tlng=pt |
| _version_ | 1818752992488194048 |
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| author | Lucas Aguiar Alencar de Oliveira Antonio Fortes de Pádua Filho Maria Adélia Medeiros e Melo Elisa Rosa de Carvalho Gonçalves Nunes Galvão Mharcus Carneiro Vieira Jerúsia Oliveira Ibiapina Danilo Rafael da Silva Fontinele Sabas Carlos Vieira |
| author_facet | Lucas Aguiar Alencar de Oliveira Antonio Fortes de Pádua Filho Maria Adélia Medeiros e Melo Elisa Rosa de Carvalho Gonçalves Nunes Galvão Mharcus Carneiro Vieira Jerúsia Oliveira Ibiapina Danilo Rafael da Silva Fontinele Sabas Carlos Vieira |
| author_sort | Lucas Aguiar Alencar de Oliveira |
| collection | DOAJ |
| description | ABSTRACT Angiosarcoma of the breast accounts for less than 1% of breast tumors. This tumor may be primary or secondary to previous radiation therapy and it is also named “radiogenic angiosarcoma of the breast”, which is still a rare entity with a poor prognosis. So far, there are only 307 cases reported about these tumors in the literature. We present a case of a 73-year-old woman with a prior history of breast-conserving treatment of right breast cancer, exhibiting mild pinkish skin changes in the ipsilateral breast. Her mammography was consistent with benign alterations (BI-RADS 2). On incisional biopsy specimens, hematoxylin-eosin showed atypical vascular lesion and suggested immunohistochemisty for diagnostic elucidation. Resection of the lesions was performed and histology showed radiogenic angiosarcoma. The patient underwent simple mastectomy. Immunohistochemistry was positive for antigens related to CD31 and CD34, and C-MYC oncogene amplification, confirming the diagnosis of angiosarcoma induced by breast irradiation. A delayed diagnosis is an important concern. Initial skin changes in radiogenic angiosarcoma are subtle, therefore, these alterations may be confused with other benign skin conditions such as telangiectasia. We highlight this case clinical aspects with the intention of alerting to the possibility of angiosarcoma of the breast in patients with a previous history of adjuvant radiation therapy for breast cancer treatment. Sixteen months after the surgery the patient remains asymptomatic. |
| first_indexed | 2024-12-18T05:00:16Z |
| format | Article |
| id | doaj.art-c029fcec0895409bb067050a8fd35c32 |
| institution | Directory Open Access Journal |
| issn | 2317-6385 |
| language | English |
| last_indexed | 2024-12-18T05:00:16Z |
| publishDate | 2020-12-01 |
| publisher | Instituto Israelita de Ensino e Pesquisa Albert Einstein |
| record_format | Article |
| series | Einstein (São Paulo) |
| spelling | doaj.art-c029fcec0895409bb067050a8fd35c322022-12-21T21:20:10ZengInstituto Israelita de Ensino e Pesquisa Albert EinsteinEinstein (São Paulo)2317-63852020-12-011810.31744/einstein_journal/2020rc5439Radiation-induced angiosarcoma: case reportLucas Aguiar Alencar de Oliveirahttps://orcid.org/0000-0002-2363-1759Antonio Fortes de Pádua Filhohttps://orcid.org/0000-0002-7074-8001Maria Adélia Medeiros e Melohttps://orcid.org/0000-0003-0484-0480Elisa Rosa de Carvalho Gonçalves Nunes Galvãohttps://orcid.org/0000-0003-0357-802XMharcus Carneiro Vieirahttps://orcid.org/0000-0002-6410-9393Jerúsia Oliveira Ibiapinahttps://orcid.org/0000-0001-5903-8351Danilo Rafael da Silva Fontinelehttps://orcid.org/0000-0001-8754-6871Sabas Carlos Vieirahttps://orcid.org/0000-0003-0935-7316ABSTRACT Angiosarcoma of the breast accounts for less than 1% of breast tumors. This tumor may be primary or secondary to previous radiation therapy and it is also named “radiogenic angiosarcoma of the breast”, which is still a rare entity with a poor prognosis. So far, there are only 307 cases reported about these tumors in the literature. We present a case of a 73-year-old woman with a prior history of breast-conserving treatment of right breast cancer, exhibiting mild pinkish skin changes in the ipsilateral breast. Her mammography was consistent with benign alterations (BI-RADS 2). On incisional biopsy specimens, hematoxylin-eosin showed atypical vascular lesion and suggested immunohistochemisty for diagnostic elucidation. Resection of the lesions was performed and histology showed radiogenic angiosarcoma. The patient underwent simple mastectomy. Immunohistochemistry was positive for antigens related to CD31 and CD34, and C-MYC oncogene amplification, confirming the diagnosis of angiosarcoma induced by breast irradiation. A delayed diagnosis is an important concern. Initial skin changes in radiogenic angiosarcoma are subtle, therefore, these alterations may be confused with other benign skin conditions such as telangiectasia. We highlight this case clinical aspects with the intention of alerting to the possibility of angiosarcoma of the breast in patients with a previous history of adjuvant radiation therapy for breast cancer treatment. Sixteen months after the surgery the patient remains asymptomatic.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082020000100518&tlng=ptHemangiosarcomaBreast neoplasms/radiotherapyMastectomy |
| spellingShingle | Lucas Aguiar Alencar de Oliveira Antonio Fortes de Pádua Filho Maria Adélia Medeiros e Melo Elisa Rosa de Carvalho Gonçalves Nunes Galvão Mharcus Carneiro Vieira Jerúsia Oliveira Ibiapina Danilo Rafael da Silva Fontinele Sabas Carlos Vieira Radiation-induced angiosarcoma: case report Einstein (São Paulo) Hemangiosarcoma Breast neoplasms/radiotherapy Mastectomy |
| title | Radiation-induced angiosarcoma: case report |
| title_full | Radiation-induced angiosarcoma: case report |
| title_fullStr | Radiation-induced angiosarcoma: case report |
| title_full_unstemmed | Radiation-induced angiosarcoma: case report |
| title_short | Radiation-induced angiosarcoma: case report |
| title_sort | radiation induced angiosarcoma case report |
| topic | Hemangiosarcoma Breast neoplasms/radiotherapy Mastectomy |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082020000100518&tlng=pt |
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