ALS-linked FUS R521C disrupts arginine methylation of UBAP2L and stress granule dynamics

ALS-linked FUS R521C disrupts arginine methylation of UBAP2L and stress granule dynamics

Abstract Mutations in the fused-in-sarcoma (FUS) gene have been linked to familial amyotrophic lateral sclerosis (fALS). FUS aggregates in the cytosol and associates with stress granules (SGs) in pathological cases, whereas FUS is normally found in the nucleus. However, little is known about how FUS...

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Bibliographic Details
Main Authors: Mi-Hee Jun, Sang-Hee Lee, Yang Hoon Huh
Format: Article
Language:English
Published: SpringerOpen 2023-05-01
Series:Journal of Analytical Science and Technology
Subjects:
Amyotrophic lateral sclerosis
FUS
UBAP2L
Methylation
Post-translational modification
Stress granule aggregates
Online Access:https://doi.org/10.1186/s40543-023-00389-y

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