A Comprehensive Analysis of Gene Expression Evolution Between Humans and Mice
Evolutionary changes in gene expression account for most phenotypic differences between species. Advances in microarray technology have made the systematic study of gene expression evolution possible. In this study, gene expression patterns were compared between human and mouse genomes using two pub...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2009-01-01
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| Series: | Evolutionary Bioinformatics |
| Subjects: | |
| Online Access: | http://www.la-press.com/a-comprehensive-analysis-of-gene-expression-evolution-between-humans-a-a1527 |
| _version_ | 1818997193385705472 |
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| author | Yupeng Wang Romdhane Rekaya |
| author_facet | Yupeng Wang Romdhane Rekaya |
| author_sort | Yupeng Wang |
| collection | DOAJ |
| description | Evolutionary changes in gene expression account for most phenotypic differences between species. Advances in microarray technology have made the systematic study of gene expression evolution possible. In this study, gene expression patterns were compared between human and mouse genomes using two published methods. Specifically, we studied how gene expression evolution was related to GO terms and tried to decode the relationship between promoter evolution and gene expression evolution. The results showed that (1) the significant enrichment of biological processes in orthologs of expression conservation reveals functional significance of gene expression conservation. The more conserved gene expression in some biological processes than is expected in a purely neutral model reveals negative selection on gene expression. However, fast evolving genes mainly support the neutrality of gene expression evolution, and (2) gene expression conservation is positively but only slightly correlated with promoter conservation based on a motif-count score of the promoter alignment. Our results suggest a neutral model with negative selection for gene expression evolution between humans and mice, and promoter evolution could have some effects on gene expression evolution. |
| first_indexed | 2024-12-20T21:41:44Z |
| format | Article |
| id | doaj.art-c02d2c5e62e04112855be8a6f8143c9c |
| institution | Directory Open Access Journal |
| issn | 1176-9343 |
| language | English |
| last_indexed | 2024-12-20T21:41:44Z |
| publishDate | 2009-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Evolutionary Bioinformatics |
| spelling | doaj.art-c02d2c5e62e04112855be8a6f8143c9c2022-12-21T19:25:48ZengSAGE PublishingEvolutionary Bioinformatics1176-93432009-01-0158190A Comprehensive Analysis of Gene Expression Evolution Between Humans and MiceYupeng WangRomdhane RekayaEvolutionary changes in gene expression account for most phenotypic differences between species. Advances in microarray technology have made the systematic study of gene expression evolution possible. In this study, gene expression patterns were compared between human and mouse genomes using two published methods. Specifically, we studied how gene expression evolution was related to GO terms and tried to decode the relationship between promoter evolution and gene expression evolution. The results showed that (1) the significant enrichment of biological processes in orthologs of expression conservation reveals functional significance of gene expression conservation. The more conserved gene expression in some biological processes than is expected in a purely neutral model reveals negative selection on gene expression. However, fast evolving genes mainly support the neutrality of gene expression evolution, and (2) gene expression conservation is positively but only slightly correlated with promoter conservation based on a motif-count score of the promoter alignment. Our results suggest a neutral model with negative selection for gene expression evolution between humans and mice, and promoter evolution could have some effects on gene expression evolution.http://www.la-press.com/a-comprehensive-analysis-of-gene-expression-evolution-between-humans-a-a1527gene expressionevolutionorthologneutral modelpromoter |
| spellingShingle | Yupeng Wang Romdhane Rekaya A Comprehensive Analysis of Gene Expression Evolution Between Humans and Mice Evolutionary Bioinformatics gene expression evolution ortholog neutral model promoter |
| title | A Comprehensive Analysis of Gene Expression Evolution Between Humans and Mice |
| title_full | A Comprehensive Analysis of Gene Expression Evolution Between Humans and Mice |
| title_fullStr | A Comprehensive Analysis of Gene Expression Evolution Between Humans and Mice |
| title_full_unstemmed | A Comprehensive Analysis of Gene Expression Evolution Between Humans and Mice |
| title_short | A Comprehensive Analysis of Gene Expression Evolution Between Humans and Mice |
| title_sort | comprehensive analysis of gene expression evolution between humans and mice |
| topic | gene expression evolution ortholog neutral model promoter |
| url | http://www.la-press.com/a-comprehensive-analysis-of-gene-expression-evolution-between-humans-a-a1527 |
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