Physical Exercise as Personalized Medicine for Dementia Prevention?
Accumulating evidence mainly from observational studies supports the notion that lifestyle factors such as regular physical activity can modulate potential risk factors of dementia. Regarding a potential mechanism for this interaction, results from intervention studies show that exercising can induc...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-05-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2019.00672/full |
| _version_ | 1811270443979505664 |
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| author | Patrick Müllers Marco Taubert Marco Taubert Notger G. Müller Notger G. Müller Notger G. Müller |
| author_facet | Patrick Müllers Marco Taubert Marco Taubert Notger G. Müller Notger G. Müller Notger G. Müller |
| author_sort | Patrick Müllers |
| collection | DOAJ |
| description | Accumulating evidence mainly from observational studies supports the notion that lifestyle factors such as regular physical activity can modulate potential risk factors of dementia. Regarding a potential mechanism for this interaction, results from intervention studies show that exercising can induce neuroplastic changes in the human brain. However, a detailed look at the study results reveals a wide interindividual variability in the observed effects. This heterogeneity may originate from the fact that there are “responders” and “non-responders” with respect to the impact of physical exercise on physiological outcome parameters (i.e., VO2 peak) and the brain. From this, it follows that recommendations for physical exercise programs should not follow a “one size fits all” approach. Instead, we propose that the exercises should be tailored to an individual in order to maximize the potential neuroplastic and preventive effects of regular exercise. These adaptations should take the individual performance levels into account and impact both the quality (i.e., type) and the quantity of exercises (i.e., intensity, duration, and volume). |
| first_indexed | 2024-04-12T22:02:00Z |
| format | Article |
| id | doaj.art-c02dc93815e049318049c3578ed1bcf2 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-12T22:02:00Z |
| publishDate | 2019-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-c02dc93815e049318049c3578ed1bcf22022-12-22T03:15:06ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2019-05-011010.3389/fphys.2019.00672451073Physical Exercise as Personalized Medicine for Dementia Prevention?Patrick Müllers0Marco Taubert1Marco Taubert2Notger G. Müller3Notger G. Müller4Notger G. Müller5Neuroprotection Laboratory, German Center for Neurodegenerative Diseases (DZNE), Magdeburg, GermanyInstitute of Sport Science, Otto-von-Guericke University Magdeburg, Magdeburg, GermanyCenter for Behavioral Brain Sciences (CBBS), Magdeburg, GermanyNeuroprotection Laboratory, German Center for Neurodegenerative Diseases (DZNE), Magdeburg, GermanyCenter for Behavioral Brain Sciences (CBBS), Magdeburg, GermanyMedical Faculty, Clinic for Neurology, Otto-von-Guericke University Magdeburg, Magdeburg, GermanyAccumulating evidence mainly from observational studies supports the notion that lifestyle factors such as regular physical activity can modulate potential risk factors of dementia. Regarding a potential mechanism for this interaction, results from intervention studies show that exercising can induce neuroplastic changes in the human brain. However, a detailed look at the study results reveals a wide interindividual variability in the observed effects. This heterogeneity may originate from the fact that there are “responders” and “non-responders” with respect to the impact of physical exercise on physiological outcome parameters (i.e., VO2 peak) and the brain. From this, it follows that recommendations for physical exercise programs should not follow a “one size fits all” approach. Instead, we propose that the exercises should be tailored to an individual in order to maximize the potential neuroplastic and preventive effects of regular exercise. These adaptations should take the individual performance levels into account and impact both the quality (i.e., type) and the quantity of exercises (i.e., intensity, duration, and volume).https://www.frontiersin.org/article/10.3389/fphys.2019.00672/fullexercisedementianeuroplasticitypersonalized medicineresponder |
| spellingShingle | Patrick Müllers Marco Taubert Marco Taubert Notger G. Müller Notger G. Müller Notger G. Müller Physical Exercise as Personalized Medicine for Dementia Prevention? Frontiers in Physiology exercise dementia neuroplasticity personalized medicine responder |
| title | Physical Exercise as Personalized Medicine for Dementia Prevention? |
| title_full | Physical Exercise as Personalized Medicine for Dementia Prevention? |
| title_fullStr | Physical Exercise as Personalized Medicine for Dementia Prevention? |
| title_full_unstemmed | Physical Exercise as Personalized Medicine for Dementia Prevention? |
| title_short | Physical Exercise as Personalized Medicine for Dementia Prevention? |
| title_sort | physical exercise as personalized medicine for dementia prevention |
| topic | exercise dementia neuroplasticity personalized medicine responder |
| url | https://www.frontiersin.org/article/10.3389/fphys.2019.00672/full |
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