Murici (<i>Byrsonima crassifolia</i> (L.) <i>Kunth</i> and <i>verbascifolia</i> (L.)) and Tapereba (<i>Spondias mombin</i>) Improve Hepatic and Inflammatory Biomarkers in High-Fat-Diet Rats
The present study investigated the effects of murici and tapereba on improving hepatic and inflammatory biomarkers in high-fat-diet rats. Female Wistar rats were divided into five groups (<i>n</i> = 10/group): control (CON), high-fat diet (HF), murici drink + high-fat diet (Mu-HF), taper...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/12/2/255 |
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| author | Vanessa Rosse de Souza Thuane Passos Barbosa Lima Teresa Palmiciano Bedê Sabrina Baptista Alves Faria Renata Alves Alana Louzada Bianca Portugal Tavares de Moraes Adriana Ribeiro Silva Cassiano Felippe Gonçalves de Albuquerque Vilma Blondet de Azeredo Anderson Junger Teodoro |
| author_facet | Vanessa Rosse de Souza Thuane Passos Barbosa Lima Teresa Palmiciano Bedê Sabrina Baptista Alves Faria Renata Alves Alana Louzada Bianca Portugal Tavares de Moraes Adriana Ribeiro Silva Cassiano Felippe Gonçalves de Albuquerque Vilma Blondet de Azeredo Anderson Junger Teodoro |
| author_sort | Vanessa Rosse de Souza |
| collection | DOAJ |
| description | The present study investigated the effects of murici and tapereba on improving hepatic and inflammatory biomarkers in high-fat-diet rats. Female Wistar rats were divided into five groups (<i>n</i> = 10/group): control (CON), high-fat diet (HF), murici drink + high-fat diet (Mu-HF), tapereba drink + high-fat diet (Tap-HF), and murici and tapereba blend drink + high-fat diet (MT-HF). Drinks were offered daily for 60 days, following which body and liver weights, hepatosomatic indexes, serum parameters, inflammatory profile, and antioxidant activity (DPPH and ORAC) were analyzed. The cell death of hepatic cells was evaluated using flow cytometry. It was observed that weight gain was similar among the groups, while glycemia was lower in the MT-HF group. A high-fat diet increased the concentration of cholesterol total, ALT, IL-1β (in plasma and liver), and TNF-α (in the liver), and this was reduced by treatment with the fruit-based beverages. The other evaluated parameters showed no statistically significant difference. Compared to the CON and HF groups, the groups that received the drinks had higher cellular antioxidant activity and reduced oxidative stress, lipid oxidation, and development of pro-inflammatory cytokines, such as IL-1β. A high-fat diet induced higher cell death in hepatic tissue, which was prevented by the murici, tapereba, and the fruit-blend drinks. The consumption of murici, tapereba, and fruit-blend-based beverages showed beneficial effects on liver metabolism; therefore, they may serve as a nutritional approach for preventing and treating non-alcoholic liver disease. |
| first_indexed | 2024-03-09T12:45:12Z |
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| id | doaj.art-c02e37e6fff1457785d5a7bf33b0caf1 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-09T12:45:12Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
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| series | Foods |
| spelling | doaj.art-c02e37e6fff1457785d5a7bf33b0caf12023-11-30T22:13:44ZengMDPI AGFoods2304-81582023-01-0112225510.3390/foods12020255Murici (<i>Byrsonima crassifolia</i> (L.) <i>Kunth</i> and <i>verbascifolia</i> (L.)) and Tapereba (<i>Spondias mombin</i>) Improve Hepatic and Inflammatory Biomarkers in High-Fat-Diet RatsVanessa Rosse de Souza0Thuane Passos Barbosa Lima1Teresa Palmiciano Bedê2Sabrina Baptista Alves Faria3Renata Alves4Alana Louzada5Bianca Portugal Tavares de Moraes6Adriana Ribeiro Silva7Cassiano Felippe Gonçalves de Albuquerque8Vilma Blondet de Azeredo9Anderson Junger Teodoro10Food and Nutrition Program, Functional Foods Laboratory, Federal University of the State of Rio de Janeiro, Rio de Janeiro 22290-240, BrazilFood and Nutrition Program, Functional Foods Laboratory, Federal University of the State of Rio de Janeiro, Rio de Janeiro 22290-240, BrazilDepartment of Nutrition and Dietetics, Fluminense Federal University, Rio de Janeiro 24020-140, BrazilDepartment of Nutrition and Dietetics, Fluminense Federal University, Rio de Janeiro 24020-140, BrazilMembrane Transport Laboratory, State University of Rio de Janeiro, Rio de Janeiro 24020-140, BrazilDepartment of Nutrition and Dietetics, Fluminense Federal University, Rio de Janeiro 24020-140, BrazilImmunopharmacology Laboratory, Biomedical Institute, Federal University of the State of Rio de Janeiro, Rio de Janeiro 21941-902, BrazilImmunopharmacology Laboratory, Oswaldo Cruz, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-900, BrazilImmunopharmacology Laboratory, Biomedical Institute, Federal University of the State of Rio de Janeiro, Rio de Janeiro 21941-902, BrazilDepartment of Nutrition and Dietetics, Fluminense Federal University, Rio de Janeiro 24020-140, BrazilFood and Nutrition Program, Functional Foods Laboratory, Federal University of the State of Rio de Janeiro, Rio de Janeiro 22290-240, BrazilThe present study investigated the effects of murici and tapereba on improving hepatic and inflammatory biomarkers in high-fat-diet rats. Female Wistar rats were divided into five groups (<i>n</i> = 10/group): control (CON), high-fat diet (HF), murici drink + high-fat diet (Mu-HF), tapereba drink + high-fat diet (Tap-HF), and murici and tapereba blend drink + high-fat diet (MT-HF). Drinks were offered daily for 60 days, following which body and liver weights, hepatosomatic indexes, serum parameters, inflammatory profile, and antioxidant activity (DPPH and ORAC) were analyzed. The cell death of hepatic cells was evaluated using flow cytometry. It was observed that weight gain was similar among the groups, while glycemia was lower in the MT-HF group. A high-fat diet increased the concentration of cholesterol total, ALT, IL-1β (in plasma and liver), and TNF-α (in the liver), and this was reduced by treatment with the fruit-based beverages. The other evaluated parameters showed no statistically significant difference. Compared to the CON and HF groups, the groups that received the drinks had higher cellular antioxidant activity and reduced oxidative stress, lipid oxidation, and development of pro-inflammatory cytokines, such as IL-1β. A high-fat diet induced higher cell death in hepatic tissue, which was prevented by the murici, tapereba, and the fruit-blend drinks. The consumption of murici, tapereba, and fruit-blend-based beverages showed beneficial effects on liver metabolism; therefore, they may serve as a nutritional approach for preventing and treating non-alcoholic liver disease.https://www.mdpi.com/2304-8158/12/2/255anti-inflammatory activityantioxidantsapoptosiscarotenoidsfunctional nutritionhigh-fat diet |
| spellingShingle | Vanessa Rosse de Souza Thuane Passos Barbosa Lima Teresa Palmiciano Bedê Sabrina Baptista Alves Faria Renata Alves Alana Louzada Bianca Portugal Tavares de Moraes Adriana Ribeiro Silva Cassiano Felippe Gonçalves de Albuquerque Vilma Blondet de Azeredo Anderson Junger Teodoro Murici (<i>Byrsonima crassifolia</i> (L.) <i>Kunth</i> and <i>verbascifolia</i> (L.)) and Tapereba (<i>Spondias mombin</i>) Improve Hepatic and Inflammatory Biomarkers in High-Fat-Diet Rats Foods anti-inflammatory activity antioxidants apoptosis carotenoids functional nutrition high-fat diet |
| title | Murici (<i>Byrsonima crassifolia</i> (L.) <i>Kunth</i> and <i>verbascifolia</i> (L.)) and Tapereba (<i>Spondias mombin</i>) Improve Hepatic and Inflammatory Biomarkers in High-Fat-Diet Rats |
| title_full | Murici (<i>Byrsonima crassifolia</i> (L.) <i>Kunth</i> and <i>verbascifolia</i> (L.)) and Tapereba (<i>Spondias mombin</i>) Improve Hepatic and Inflammatory Biomarkers in High-Fat-Diet Rats |
| title_fullStr | Murici (<i>Byrsonima crassifolia</i> (L.) <i>Kunth</i> and <i>verbascifolia</i> (L.)) and Tapereba (<i>Spondias mombin</i>) Improve Hepatic and Inflammatory Biomarkers in High-Fat-Diet Rats |
| title_full_unstemmed | Murici (<i>Byrsonima crassifolia</i> (L.) <i>Kunth</i> and <i>verbascifolia</i> (L.)) and Tapereba (<i>Spondias mombin</i>) Improve Hepatic and Inflammatory Biomarkers in High-Fat-Diet Rats |
| title_short | Murici (<i>Byrsonima crassifolia</i> (L.) <i>Kunth</i> and <i>verbascifolia</i> (L.)) and Tapereba (<i>Spondias mombin</i>) Improve Hepatic and Inflammatory Biomarkers in High-Fat-Diet Rats |
| title_sort | murici i byrsonima crassifolia i l i kunth i and i verbascifolia i l and tapereba i spondias mombin i improve hepatic and inflammatory biomarkers in high fat diet rats |
| topic | anti-inflammatory activity antioxidants apoptosis carotenoids functional nutrition high-fat diet |
| url | https://www.mdpi.com/2304-8158/12/2/255 |
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