Fixed-dose combination of sitagliptin and metformin for the treatment of type 2 diabetes
Jonathan K ReynoldsWashington State University, College of Pharmacy, Pullman, WA, USAAbstract: JanumetTM, a fixed dose combination of sitagliptin/metformin HCL manufactured by Merck Pharmaceuticals, has received US Food and Drug Administration approval for treatment of patients with type 2 diabetes,...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2009-07-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
| Online Access: | http://www.dovepress.com/fixed-dose-combination-of-sitagliptin-and-metformin-for-the-treatment--a3384 |
| _version_ | 1811174035185205248 |
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| author | Jonathan K Reynolds |
| author_facet | Jonathan K Reynolds |
| author_sort | Jonathan K Reynolds |
| collection | DOAJ |
| description | Jonathan K ReynoldsWashington State University, College of Pharmacy, Pullman, WA, USAAbstract: JanumetTM, a fixed dose combination of sitagliptin/metformin HCL manufactured by Merck Pharmaceuticals, has received US Food and Drug Administration approval for treatment of patients with type 2 diabetes, that are inadequately controlled, either by sitagliptin or metformin alone or together in free-dose combination form. Sitagliptin, an inhibitor of the enzyme DDP-4, assists patients with type 2 diabetes mellitus to achieve glycemic control. It has been shown to be safe and effective at 100 mg daily doses. The effect of giving sitagliptin in combination with metformin is thought to have a complimentary and possibly additive effect on glycemic control.Keywords: sitagliptin, metformin, fixed-dose combination, dipeptidyl peptidase-4 inhibitor, DPP-4 inhibitor |
| first_indexed | 2024-04-10T17:56:34Z |
| format | Article |
| id | doaj.art-c03116aca28d4503b4a56a3c00a08e98 |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T17:56:34Z |
| publishDate | 2009-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-c03116aca28d4503b4a56a3c00a08e982023-02-02T18:01:11ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072009-07-012009default127134Fixed-dose combination of sitagliptin and metformin for the treatment of type 2 diabetesJonathan K ReynoldsJonathan K ReynoldsWashington State University, College of Pharmacy, Pullman, WA, USAAbstract: JanumetTM, a fixed dose combination of sitagliptin/metformin HCL manufactured by Merck Pharmaceuticals, has received US Food and Drug Administration approval for treatment of patients with type 2 diabetes, that are inadequately controlled, either by sitagliptin or metformin alone or together in free-dose combination form. Sitagliptin, an inhibitor of the enzyme DDP-4, assists patients with type 2 diabetes mellitus to achieve glycemic control. It has been shown to be safe and effective at 100 mg daily doses. The effect of giving sitagliptin in combination with metformin is thought to have a complimentary and possibly additive effect on glycemic control.Keywords: sitagliptin, metformin, fixed-dose combination, dipeptidyl peptidase-4 inhibitor, DPP-4 inhibitorhttp://www.dovepress.com/fixed-dose-combination-of-sitagliptin-and-metformin-for-the-treatment--a3384 |
| spellingShingle | Jonathan K Reynolds Fixed-dose combination of sitagliptin and metformin for the treatment of type 2 diabetes Diabetes, Metabolic Syndrome and Obesity |
| title | Fixed-dose combination of sitagliptin and metformin for the treatment of type 2 diabetes |
| title_full | Fixed-dose combination of sitagliptin and metformin for the treatment of type 2 diabetes |
| title_fullStr | Fixed-dose combination of sitagliptin and metformin for the treatment of type 2 diabetes |
| title_full_unstemmed | Fixed-dose combination of sitagliptin and metformin for the treatment of type 2 diabetes |
| title_short | Fixed-dose combination of sitagliptin and metformin for the treatment of type 2 diabetes |
| title_sort | fixed dose combination of sitagliptin and metformin for the treatment of type 2 diabetes |
| url | http://www.dovepress.com/fixed-dose-combination-of-sitagliptin-and-metformin-for-the-treatment--a3384 |
| work_keys_str_mv | AT jonathankreynolds fixeddosecombinationofsitagliptinandmetforminforthetreatmentoftype2diabetes |