Effect of perinatal risk factors on neutrophil gelatinase-associated lipocalin (NGAL) level in umbilical and peripheral blood in neonates
Introduction: Acute kidney injury biomarkers are opening a new era in diagnosing kidney failure. The requirement for a specific and sensitive marker of kidney function is highly desirable in neonates because the diagnostic possibilities in this age group are not sufficient. Recent research show th...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2017-10-01
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| Series: | Central European Journal of Immunology |
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| Online Access: | https://www.termedia.pl/Effect-of-perinatal-risk-factors-on-neutrophil-gelatinase-associated-lipocalin-NGAL-level-in-umbilical-and-peripheral-blood-in-neonates,10,30872,1,1.html |
| _version_ | 1827058508729679872 |
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| author | Agnieszka Kisiel Maria Roszkowska-Blaim Małgorzata Pańczyk-Tomaszewska Anna Stelmaszczyk-Emmel Elżbieta Górska Maria Borszewska-Kornacka |
| author_facet | Agnieszka Kisiel Maria Roszkowska-Blaim Małgorzata Pańczyk-Tomaszewska Anna Stelmaszczyk-Emmel Elżbieta Górska Maria Borszewska-Kornacka |
| author_sort | Agnieszka Kisiel |
| collection | DOAJ |
| description | Introduction: Acute kidney injury biomarkers are opening a new era in diagnosing kidney failure. The requirement for a specific and sensitive marker of kidney function is highly desirable in neonates because the diagnostic possibilities in this age group are not sufficient. Recent research show that neutrophil gelatinase-associated lipocalin (NGAL) can have a great potential but there is a wide range of medical conditions, that may influence their expression.
The aim of the study was to evaluate the impact of perinatal risk factors on NGAL level in neonates.
Material and methods : NGAL was measured in umbilical cord blood and peripheral blood in full term neonates with perinatal risk factors during the first days of life.
Results : We found significantly higher umbilical cord blood NGAL levels in neonates with perinatal risk factors (117.69 ng/ml) compared to the control group (64.37 ng/ml). No significant difference in peripheral blood NGAL level was shown between the two groups. Umbilical cord blood NGAL level correlated positively with peripheral blood NGAL level (r = 0.36, p < 0.01). Umbilical cord blood NGAL level was significantly higher in neonates with fetal distress and infection compared to neonates with other perinatal risk factors. Peripheral blood NGAL level was significantly higher in neonates with infection compared to neonates with other perinatal risk factors. Significantly higher umbilical cord blood NGAL levels were seen in neonates born by operative delivery compared to born by natural delivery. |
| first_indexed | 2024-04-11T22:56:35Z |
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| id | doaj.art-c032553238c54a8ca4125506778d6473 |
| institution | Directory Open Access Journal |
| issn | 1426-3912 1644-4124 |
| language | English |
| last_indexed | 2025-02-18T18:25:09Z |
| publishDate | 2017-10-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Central European Journal of Immunology |
| spelling | doaj.art-c032553238c54a8ca4125506778d64732024-10-22T08:02:29ZengTermedia Publishing HouseCentral European Journal of Immunology1426-39121644-41242017-10-0142327428010.5114/ceji.2017.7097030872Effect of perinatal risk factors on neutrophil gelatinase-associated lipocalin (NGAL) level in umbilical and peripheral blood in neonatesAgnieszka KisielMaria Roszkowska-BlaimMałgorzata Pańczyk-TomaszewskaAnna Stelmaszczyk-EmmelElżbieta GórskaMaria Borszewska-KornackaIntroduction: Acute kidney injury biomarkers are opening a new era in diagnosing kidney failure. The requirement for a specific and sensitive marker of kidney function is highly desirable in neonates because the diagnostic possibilities in this age group are not sufficient. Recent research show that neutrophil gelatinase-associated lipocalin (NGAL) can have a great potential but there is a wide range of medical conditions, that may influence their expression. The aim of the study was to evaluate the impact of perinatal risk factors on NGAL level in neonates. Material and methods : NGAL was measured in umbilical cord blood and peripheral blood in full term neonates with perinatal risk factors during the first days of life. Results : We found significantly higher umbilical cord blood NGAL levels in neonates with perinatal risk factors (117.69 ng/ml) compared to the control group (64.37 ng/ml). No significant difference in peripheral blood NGAL level was shown between the two groups. Umbilical cord blood NGAL level correlated positively with peripheral blood NGAL level (r = 0.36, p < 0.01). Umbilical cord blood NGAL level was significantly higher in neonates with fetal distress and infection compared to neonates with other perinatal risk factors. Peripheral blood NGAL level was significantly higher in neonates with infection compared to neonates with other perinatal risk factors. Significantly higher umbilical cord blood NGAL levels were seen in neonates born by operative delivery compared to born by natural delivery.https://www.termedia.pl/Effect-of-perinatal-risk-factors-on-neutrophil-gelatinase-associated-lipocalin-NGAL-level-in-umbilical-and-peripheral-blood-in-neonates,10,30872,1,1.htmlneonates NGAL AKI biomarkers |
| spellingShingle | Agnieszka Kisiel Maria Roszkowska-Blaim Małgorzata Pańczyk-Tomaszewska Anna Stelmaszczyk-Emmel Elżbieta Górska Maria Borszewska-Kornacka Effect of perinatal risk factors on neutrophil gelatinase-associated lipocalin (NGAL) level in umbilical and peripheral blood in neonates Central European Journal of Immunology neonates NGAL AKI biomarkers |
| title | Effect of perinatal risk factors on neutrophil gelatinase-associated lipocalin (NGAL) level in umbilical and peripheral blood in neonates |
| title_full | Effect of perinatal risk factors on neutrophil gelatinase-associated lipocalin (NGAL) level in umbilical and peripheral blood in neonates |
| title_fullStr | Effect of perinatal risk factors on neutrophil gelatinase-associated lipocalin (NGAL) level in umbilical and peripheral blood in neonates |
| title_full_unstemmed | Effect of perinatal risk factors on neutrophil gelatinase-associated lipocalin (NGAL) level in umbilical and peripheral blood in neonates |
| title_short | Effect of perinatal risk factors on neutrophil gelatinase-associated lipocalin (NGAL) level in umbilical and peripheral blood in neonates |
| title_sort | effect of perinatal risk factors on neutrophil gelatinase associated lipocalin ngal level in umbilical and peripheral blood in neonates |
| topic | neonates NGAL AKI biomarkers |
| url | https://www.termedia.pl/Effect-of-perinatal-risk-factors-on-neutrophil-gelatinase-associated-lipocalin-NGAL-level-in-umbilical-and-peripheral-blood-in-neonates,10,30872,1,1.html |
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