Transcriptomic Profiling of Tumor-Infiltrating CD4<sup>+</sup>TIM-3<sup>+</sup> T Cells Reveals Their Suppressive, Exhausted, and Metastatic Characteristics in Colorectal Cancer Patients

Transcriptomic Profiling of Tumor-Infiltrating CD4<sup>+</sup>TIM-3<sup>+</sup> T Cells Reveals Their Suppressive, Exhausted, and Metastatic Characteristics in Colorectal Cancer Patients

T cell immunoglobulin mucin-3 (TIM-3) is an immune checkpoint identified as one of the key players in regulating T-cell responses. Studies have shown that TIM-3 is upregulated in the tumor microenvironment (TME). However, the precise role of TIM-3 in colorectal cancer (CRC) TME is yet to be elucidat...

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Bibliographic Details
Main Authors: Varun Sasidharan Nair, Salman M Toor, Rowaida Z Taha, Ayman A Ahmed, Mohamed A Kurer, Khaled Murshed, Madiha E Soofi, Khalid Ouararhni, Nehad M. Alajez, Mohamed Abu Nada, Eyad Elkord
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Vaccines
Subjects:
colorectal cancer
tumor microenvironment
t cell immunoglobulin mucin-3
exhausted t cells
metastasis
Online Access:https://www.mdpi.com/2076-393X/8/1/71

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