New formulation of a recombinant anthrax vaccine stabilised with structurally modified plant viruses

New formulation of a recombinant anthrax vaccine stabilised with structurally modified plant viruses

Anthrax is a disease caused by Bacillus anthracis. The most promising approach to the development of anthrax vaccine is use of the anthrax protective antigen (PA). At the same time, recombinant PA is a very unstable protein. Previously, the authors have designed a stable modified recombinant anthrax...

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Bibliographic Details
Main Authors: Dmitriy L. Granovskiy, Ekaterina M. Ryabchevskaya, Ekaterina A. Evtushenko, Olga A. Kondakova, Marina V. Arkhipenko, Tatiana B. Kravchenko, Irina V. Bakhteeva, Vitalii S. Timofeev, Nikolai A. Nikitin, Olga V. Karpova
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Microbiology
Subjects:
anthrax
protective antigen (PA)
vaccine candidate
plant virus
adjuvant
tobacco mosaic virus
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.1003969/full

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