Synthetic Strategies, Reactivity and Applications of 1,5-Naphthyridines
This review covers the synthesis and reactivity of 1,5-naphthyridine derivatives published in the last 18 years. These heterocycles present a significant importance in the field of medicinal chemistry because many of them exhibit a great variety of biological activities. First, the published strateg...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/14/3252 |
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| author | Maria Fuertes Carme Masdeu Endika Martin-Encinas Asier Selas Gloria Rubiales Francisco Palacios Concepcion Alonso |
| author_facet | Maria Fuertes Carme Masdeu Endika Martin-Encinas Asier Selas Gloria Rubiales Francisco Palacios Concepcion Alonso |
| author_sort | Maria Fuertes |
| collection | DOAJ |
| description | This review covers the synthesis and reactivity of 1,5-naphthyridine derivatives published in the last 18 years. These heterocycles present a significant importance in the field of medicinal chemistry because many of them exhibit a great variety of biological activities. First, the published strategies related to the synthesis of 1,5-naphthyridines are presented followed by the reactivity of these compounds with electrophilic or nucleophilic reagents, in oxidations, reductions, cross-coupling reactions, modification of side chains or formation of metal complexes. Finally, some properties and applications of these heterocycles studied during this period are examined. |
| first_indexed | 2024-03-10T18:26:06Z |
| format | Article |
| id | doaj.art-c0330e960ac142ba8983a7988582edeb |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T18:26:06Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-c0330e960ac142ba8983a7988582edeb2023-11-20T07:01:04ZengMDPI AGMolecules1420-30492020-07-012514325210.3390/molecules25143252Synthetic Strategies, Reactivity and Applications of 1,5-NaphthyridinesMaria Fuertes0Carme Masdeu1Endika Martin-Encinas2Asier Selas3Gloria Rubiales4Francisco Palacios5Concepcion Alonso6Departamento de Química Orgánica I, Facultad de Farmacia, Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU), Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, SpainDepartamento de Química Orgánica I, Facultad de Farmacia, Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU), Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, SpainDepartamento de Química Orgánica I, Facultad de Farmacia, Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU), Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, SpainDepartamento de Química Orgánica I, Facultad de Farmacia, Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU), Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, SpainDepartamento de Química Orgánica I, Facultad de Farmacia, Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU), Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, SpainDepartamento de Química Orgánica I, Facultad de Farmacia, Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU), Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, SpainDepartamento de Química Orgánica I, Facultad de Farmacia, Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU), Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, SpainThis review covers the synthesis and reactivity of 1,5-naphthyridine derivatives published in the last 18 years. These heterocycles present a significant importance in the field of medicinal chemistry because many of them exhibit a great variety of biological activities. First, the published strategies related to the synthesis of 1,5-naphthyridines are presented followed by the reactivity of these compounds with electrophilic or nucleophilic reagents, in oxidations, reductions, cross-coupling reactions, modification of side chains or formation of metal complexes. Finally, some properties and applications of these heterocycles studied during this period are examined.https://www.mdpi.com/1420-3049/25/14/32521,5-naphthyridinesheterocycle synthesismetal complexesbiological activity |
| spellingShingle | Maria Fuertes Carme Masdeu Endika Martin-Encinas Asier Selas Gloria Rubiales Francisco Palacios Concepcion Alonso Synthetic Strategies, Reactivity and Applications of 1,5-Naphthyridines Molecules 1,5-naphthyridines heterocycle synthesis metal complexes biological activity |
| title | Synthetic Strategies, Reactivity and Applications of 1,5-Naphthyridines |
| title_full | Synthetic Strategies, Reactivity and Applications of 1,5-Naphthyridines |
| title_fullStr | Synthetic Strategies, Reactivity and Applications of 1,5-Naphthyridines |
| title_full_unstemmed | Synthetic Strategies, Reactivity and Applications of 1,5-Naphthyridines |
| title_short | Synthetic Strategies, Reactivity and Applications of 1,5-Naphthyridines |
| title_sort | synthetic strategies reactivity and applications of 1 5 naphthyridines |
| topic | 1,5-naphthyridines heterocycle synthesis metal complexes biological activity |
| url | https://www.mdpi.com/1420-3049/25/14/3252 |
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