The importance of bacterial and viral infections associated with adult asthma exacerbations in clinical practice.
Viral infection is one of the risk factors for asthma exacerbation. However, which pathogens are related to asthma exacerbation in adults remains unclear.The relation between various infections and adult asthma exacerbations was investigated in clinical practice.The study subjects included 50 adult...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4406689?pdf=render |
| _version_ | 1828481467768897536 |
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| author | Motoyasu Iikura Masayuki Hojo Rikiya Koketsu Sho Watanabe Ayano Sato Haruka Chino Shoki Ro Haruna Masaki Junko Hirashima Satoru Ishii Go Naka Jin Takasaki Shinyu Izumi Nobuyuki Kobayashi Sachiko Yamaguchi Susumu Nakae Haruhito Sugiyama |
| author_facet | Motoyasu Iikura Masayuki Hojo Rikiya Koketsu Sho Watanabe Ayano Sato Haruka Chino Shoki Ro Haruna Masaki Junko Hirashima Satoru Ishii Go Naka Jin Takasaki Shinyu Izumi Nobuyuki Kobayashi Sachiko Yamaguchi Susumu Nakae Haruhito Sugiyama |
| author_sort | Motoyasu Iikura |
| collection | DOAJ |
| description | Viral infection is one of the risk factors for asthma exacerbation. However, which pathogens are related to asthma exacerbation in adults remains unclear.The relation between various infections and adult asthma exacerbations was investigated in clinical practice.The study subjects included 50 adult inpatients due to asthma exacerbations and 20 stable outpatients for comparison. The pathogens from a nasopharyngeal swab were measured by multiplex PCR analysis.Asthma exacerbations occurred after a common cold in 48 inpatients. The numbers of patients with viral, bacterial, or both infections were 16, 9, and 9, respectively. The dominant viruses were rhinoviruses, respiratory syncytial virus, influenza virus, and metapneumovirus. The major bacteria were S. pneumoniae and H. influenzae. Compared to pathogen-free patients, the patients with pathogens were older and non-atopic and had later onset of disease, lower FeNO levels, lower IgE titers, and a higher incidence of comorbid sinusitis, COPD, or pneumonia. Compared to stable outpatients, asthma exacerbation inpatients had a higher incidence of smoking and comorbid sinusitis, COPD, or pneumonia. Viruses were detected in 50% of stable outpatients, but a higher incidence of rhinovirus, respiratory syncytial virus, and metapneumovirus infections was observed in asthma exacerbation inpatients. H. influenzae was observed in stable asthmatic patients. Other bacteria, especially S. pneumoniae, were important in asthma exacerbation inpatients.Viral or bacterial infections were observed in 70% of inpatients with an asthma exacerbation in clinical practice. Infection with S. pneumoniae was related to adult asthma exacerbation. |
| first_indexed | 2024-12-11T07:57:44Z |
| format | Article |
| id | doaj.art-c034e55ca76445b882cdb85d98a83719 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T07:57:44Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-c034e55ca76445b882cdb85d98a837192022-12-22T01:15:12ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01104e012358410.1371/journal.pone.0123584The importance of bacterial and viral infections associated with adult asthma exacerbations in clinical practice.Motoyasu IikuraMasayuki HojoRikiya KoketsuSho WatanabeAyano SatoHaruka ChinoShoki RoHaruna MasakiJunko HirashimaSatoru IshiiGo NakaJin TakasakiShinyu IzumiNobuyuki KobayashiSachiko YamaguchiSusumu NakaeHaruhito SugiyamaViral infection is one of the risk factors for asthma exacerbation. However, which pathogens are related to asthma exacerbation in adults remains unclear.The relation between various infections and adult asthma exacerbations was investigated in clinical practice.The study subjects included 50 adult inpatients due to asthma exacerbations and 20 stable outpatients for comparison. The pathogens from a nasopharyngeal swab were measured by multiplex PCR analysis.Asthma exacerbations occurred after a common cold in 48 inpatients. The numbers of patients with viral, bacterial, or both infections were 16, 9, and 9, respectively. The dominant viruses were rhinoviruses, respiratory syncytial virus, influenza virus, and metapneumovirus. The major bacteria were S. pneumoniae and H. influenzae. Compared to pathogen-free patients, the patients with pathogens were older and non-atopic and had later onset of disease, lower FeNO levels, lower IgE titers, and a higher incidence of comorbid sinusitis, COPD, or pneumonia. Compared to stable outpatients, asthma exacerbation inpatients had a higher incidence of smoking and comorbid sinusitis, COPD, or pneumonia. Viruses were detected in 50% of stable outpatients, but a higher incidence of rhinovirus, respiratory syncytial virus, and metapneumovirus infections was observed in asthma exacerbation inpatients. H. influenzae was observed in stable asthmatic patients. Other bacteria, especially S. pneumoniae, were important in asthma exacerbation inpatients.Viral or bacterial infections were observed in 70% of inpatients with an asthma exacerbation in clinical practice. Infection with S. pneumoniae was related to adult asthma exacerbation.http://europepmc.org/articles/PMC4406689?pdf=render |
| spellingShingle | Motoyasu Iikura Masayuki Hojo Rikiya Koketsu Sho Watanabe Ayano Sato Haruka Chino Shoki Ro Haruna Masaki Junko Hirashima Satoru Ishii Go Naka Jin Takasaki Shinyu Izumi Nobuyuki Kobayashi Sachiko Yamaguchi Susumu Nakae Haruhito Sugiyama The importance of bacterial and viral infections associated with adult asthma exacerbations in clinical practice. PLoS ONE |
| title | The importance of bacterial and viral infections associated with adult asthma exacerbations in clinical practice. |
| title_full | The importance of bacterial and viral infections associated with adult asthma exacerbations in clinical practice. |
| title_fullStr | The importance of bacterial and viral infections associated with adult asthma exacerbations in clinical practice. |
| title_full_unstemmed | The importance of bacterial and viral infections associated with adult asthma exacerbations in clinical practice. |
| title_short | The importance of bacterial and viral infections associated with adult asthma exacerbations in clinical practice. |
| title_sort | importance of bacterial and viral infections associated with adult asthma exacerbations in clinical practice |
| url | http://europepmc.org/articles/PMC4406689?pdf=render |
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