Molecular Mechanisms of the Efficacy of Cold Atmospheric Pressure Plasma (CAP) in Cancer Treatment
Recently, the potential use of cold atmospheric pressure plasma (CAP) in cancer treatment has gained increasing interest. Especially the enhanced selective killing of tumor cells compared to normal cells has prompted researchers to elucidate the molecular mechanisms for the efficacy of CAP in cancer...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-01-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/2/269 |
| _version_ | 1797766333277929472 |
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| author | Marie Luise Semmler Sander Bekeschus Mirijam Schäfer Thoralf Bernhardt Tobias Fischer Katharina Witzke Christian Seebauer Henrike Rebl Eberhard Grambow Brigitte Vollmar J. Barbara Nebe Hans-Robert Metelmann Thomas von Woedtke Steffen Emmert Lars Boeckmann |
| author_facet | Marie Luise Semmler Sander Bekeschus Mirijam Schäfer Thoralf Bernhardt Tobias Fischer Katharina Witzke Christian Seebauer Henrike Rebl Eberhard Grambow Brigitte Vollmar J. Barbara Nebe Hans-Robert Metelmann Thomas von Woedtke Steffen Emmert Lars Boeckmann |
| author_sort | Marie Luise Semmler |
| collection | DOAJ |
| description | Recently, the potential use of cold atmospheric pressure plasma (CAP) in cancer treatment has gained increasing interest. Especially the enhanced selective killing of tumor cells compared to normal cells has prompted researchers to elucidate the molecular mechanisms for the efficacy of CAP in cancer treatment. This review summarizes the current understanding of how CAP triggers intracellular pathways that induce growth inhibition or cell death. We discuss what factors may contribute to the potential selectivity of CAP towards cancer cells compared to their non-malignant counterparts. Furthermore, the potential of CAP to trigger an immune response is briefly discussed. Finally, this overview demonstrates how these concepts bear first fruits in clinical applications applying CAP treatment in head and neck squamous cell cancer as well as actinic keratosis. Although significant progress towards understanding the underlying mechanisms regarding the efficacy of CAP in cancer treatment has been made, much still needs to be done with respect to different treatment conditions and comparison of malignant and non-malignant cells of the same cell type and same donor. Furthermore, clinical pilot studies and the assessment of systemic effects will be of tremendous importance towards bringing this innovative technology into clinical practice. |
| first_indexed | 2024-03-12T20:23:45Z |
| format | Article |
| id | doaj.art-c03659b3296e4a9aa6af2e423adcb249 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T20:23:45Z |
| publishDate | 2020-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-c03659b3296e4a9aa6af2e423adcb2492023-08-02T00:45:00ZengMDPI AGCancers2072-66942020-01-0112226910.3390/cancers12020269cancers12020269Molecular Mechanisms of the Efficacy of Cold Atmospheric Pressure Plasma (CAP) in Cancer TreatmentMarie Luise Semmler0Sander Bekeschus1Mirijam Schäfer2Thoralf Bernhardt3Tobias Fischer4Katharina Witzke5Christian Seebauer6Henrike Rebl7Eberhard Grambow8Brigitte Vollmar9J. Barbara Nebe10Hans-Robert Metelmann11Thomas von Woedtke12Steffen Emmert13Lars Boeckmann14Clinic and Polyclinic for Dermatology and Venereology, University Medical Center Rostock, 18057 Rostock, GermanyZIK <i>plasmatis</i>, Leibniz-Institute for Plasma Science and Technology (INP Greifswald), 17489 Greifswald, GermanyClinic and Polyclinic for Dermatology and Venereology, University Medical Center Rostock, 18057 Rostock, GermanyClinic and Polyclinic for Dermatology and Venereology, University Medical Center Rostock, 18057 Rostock, GermanyClinic and Polyclinic for Dermatology and Venereology, University Medical Center Rostock, 18057 Rostock, GermanyOral & Maxillofacial Surgery/Plastic Surgery, University Medicine Greifswald, 17489 Greifswald, GermanyOral & Maxillofacial Surgery/Plastic Surgery, University Medicine Greifswald, 17489 Greifswald, GermanyDepartment of Cell Biology, University Medical Center Rostock, 18057 Rostock, GermanyInstitute for Experimental Surgery, Rostock University Medical Center, 18057 Rostock, GermanyInstitute for Experimental Surgery, Rostock University Medical Center, 18057 Rostock, GermanyDepartment of Cell Biology, University Medical Center Rostock, 18057 Rostock, GermanyOral & Maxillofacial Surgery/Plastic Surgery, University Medicine Greifswald, 17489 Greifswald, GermanyZIK <i>plasmatis</i>, Leibniz-Institute for Plasma Science and Technology (INP Greifswald), 17489 Greifswald, GermanyClinic and Polyclinic for Dermatology and Venereology, University Medical Center Rostock, 18057 Rostock, GermanyClinic and Polyclinic for Dermatology and Venereology, University Medical Center Rostock, 18057 Rostock, GermanyRecently, the potential use of cold atmospheric pressure plasma (CAP) in cancer treatment has gained increasing interest. Especially the enhanced selective killing of tumor cells compared to normal cells has prompted researchers to elucidate the molecular mechanisms for the efficacy of CAP in cancer treatment. This review summarizes the current understanding of how CAP triggers intracellular pathways that induce growth inhibition or cell death. We discuss what factors may contribute to the potential selectivity of CAP towards cancer cells compared to their non-malignant counterparts. Furthermore, the potential of CAP to trigger an immune response is briefly discussed. Finally, this overview demonstrates how these concepts bear first fruits in clinical applications applying CAP treatment in head and neck squamous cell cancer as well as actinic keratosis. Although significant progress towards understanding the underlying mechanisms regarding the efficacy of CAP in cancer treatment has been made, much still needs to be done with respect to different treatment conditions and comparison of malignant and non-malignant cells of the same cell type and same donor. Furthermore, clinical pilot studies and the assessment of systemic effects will be of tremendous importance towards bringing this innovative technology into clinical practice.https://www.mdpi.com/2072-6694/12/2/269cold physical plasmaplasma medicinereactive oxygen and nitrogen species |
| spellingShingle | Marie Luise Semmler Sander Bekeschus Mirijam Schäfer Thoralf Bernhardt Tobias Fischer Katharina Witzke Christian Seebauer Henrike Rebl Eberhard Grambow Brigitte Vollmar J. Barbara Nebe Hans-Robert Metelmann Thomas von Woedtke Steffen Emmert Lars Boeckmann Molecular Mechanisms of the Efficacy of Cold Atmospheric Pressure Plasma (CAP) in Cancer Treatment Cancers cold physical plasma plasma medicine reactive oxygen and nitrogen species |
| title | Molecular Mechanisms of the Efficacy of Cold Atmospheric Pressure Plasma (CAP) in Cancer Treatment |
| title_full | Molecular Mechanisms of the Efficacy of Cold Atmospheric Pressure Plasma (CAP) in Cancer Treatment |
| title_fullStr | Molecular Mechanisms of the Efficacy of Cold Atmospheric Pressure Plasma (CAP) in Cancer Treatment |
| title_full_unstemmed | Molecular Mechanisms of the Efficacy of Cold Atmospheric Pressure Plasma (CAP) in Cancer Treatment |
| title_short | Molecular Mechanisms of the Efficacy of Cold Atmospheric Pressure Plasma (CAP) in Cancer Treatment |
| title_sort | molecular mechanisms of the efficacy of cold atmospheric pressure plasma cap in cancer treatment |
| topic | cold physical plasma plasma medicine reactive oxygen and nitrogen species |
| url | https://www.mdpi.com/2072-6694/12/2/269 |
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