A high risk of sleep apnea is associated with less postoperative cognitive dysfunction after intravenous anesthesia: results of an observational pilot study
Abstract Background The obstructive sleep apnea syndrome (OSAS) is characterized by temporary cerebral hypoxia which can cause cognitive dysfunction. On the other hand, hypoxia induced neurocognitive deficits are detectable after general anesthesia. The objective of this study was to evaluate the im...
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| Format: | Article |
| Language: | English |
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BMC
2018-10-01
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| Series: | BMC Anesthesiology |
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| Online Access: | http://link.springer.com/article/10.1186/s12871-018-0602-9 |
| _version_ | 1818522999967449088 |
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| author | Soeren Wagner Joerg Quente Sven Staedtler Katharina Koch Tanja Richter-Schmidinger Johannes Kornhuber Harald Ihmsen Juergen Schuettler |
| author_facet | Soeren Wagner Joerg Quente Sven Staedtler Katharina Koch Tanja Richter-Schmidinger Johannes Kornhuber Harald Ihmsen Juergen Schuettler |
| author_sort | Soeren Wagner |
| collection | DOAJ |
| description | Abstract Background The obstructive sleep apnea syndrome (OSAS) is characterized by temporary cerebral hypoxia which can cause cognitive dysfunction. On the other hand, hypoxia induced neurocognitive deficits are detectable after general anesthesia. The objective of this study was to evaluate the impact of a high risk of OSAS on the postoperative cognitive dysfunction after intravenous anesthesia. Methods In this single center trial between June 2012 and June 2013 43 patients aged 55 to 80 years with an estimated hospital stay of at least 3 days undergoing surgery were enrolled. Patients were screened for a high risk of OSAS using the STOP-BANG test. The cognitive function was assessed using a neuropsychological test battery, including the DemTect test for cognitive impairment and the RMBT test for memory, the day before surgery and within 36 h after extubation. Results Twenty-two of the 43 analyzed patients were identified as patients with a high risk of OSAS. Preoperatively, OSAS patients showed a significant worse performance only for the DemTect (p = 0.0043). However, when comparing pre- and postoperative test results, the OSAS patients did not show a significant loss in any test but significantly improved in RMBT test, whereas the control group showed a significant worse performance in three of eight tests. In five tests, we found a significant difference between the two groups with respect to the change from pre- to postoperative cognitive function. Conclusion Patients with a high risk of OSAS showed a less impairment of memory function and work memory performance after intravenous anesthesia. This might be explained by a beneficial effect of intrinsic hypoxic preconditioning in these patients. |
| first_indexed | 2024-12-11T05:39:57Z |
| format | Article |
| id | doaj.art-c04102f0d90b4f6398da45fadaa49c43 |
| institution | Directory Open Access Journal |
| issn | 1471-2253 |
| language | English |
| last_indexed | 2024-12-11T05:39:57Z |
| publishDate | 2018-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Anesthesiology |
| spelling | doaj.art-c04102f0d90b4f6398da45fadaa49c432022-12-22T01:19:09ZengBMCBMC Anesthesiology1471-22532018-10-0118111010.1186/s12871-018-0602-9A high risk of sleep apnea is associated with less postoperative cognitive dysfunction after intravenous anesthesia: results of an observational pilot studySoeren Wagner0Joerg Quente1Sven Staedtler2Katharina Koch3Tanja Richter-Schmidinger4Johannes Kornhuber5Harald Ihmsen6Juergen Schuettler7Department of Anesthesiology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-NurembergDepartment of Anesthesiology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-NurembergDepartment of Anesthesiology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-NurembergDepartment of Anesthesiology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-NurembergDepartment of Psychiatry and Psychotherapy, University Hospital Erlangen, Friedrich-Alexander-UniversityDepartment of Psychiatry and Psychotherapy, University Hospital Erlangen, Friedrich-Alexander-UniversityDepartment of Anesthesiology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-NurembergDepartment of Anesthesiology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-NurembergAbstract Background The obstructive sleep apnea syndrome (OSAS) is characterized by temporary cerebral hypoxia which can cause cognitive dysfunction. On the other hand, hypoxia induced neurocognitive deficits are detectable after general anesthesia. The objective of this study was to evaluate the impact of a high risk of OSAS on the postoperative cognitive dysfunction after intravenous anesthesia. Methods In this single center trial between June 2012 and June 2013 43 patients aged 55 to 80 years with an estimated hospital stay of at least 3 days undergoing surgery were enrolled. Patients were screened for a high risk of OSAS using the STOP-BANG test. The cognitive function was assessed using a neuropsychological test battery, including the DemTect test for cognitive impairment and the RMBT test for memory, the day before surgery and within 36 h after extubation. Results Twenty-two of the 43 analyzed patients were identified as patients with a high risk of OSAS. Preoperatively, OSAS patients showed a significant worse performance only for the DemTect (p = 0.0043). However, when comparing pre- and postoperative test results, the OSAS patients did not show a significant loss in any test but significantly improved in RMBT test, whereas the control group showed a significant worse performance in three of eight tests. In five tests, we found a significant difference between the two groups with respect to the change from pre- to postoperative cognitive function. Conclusion Patients with a high risk of OSAS showed a less impairment of memory function and work memory performance after intravenous anesthesia. This might be explained by a beneficial effect of intrinsic hypoxic preconditioning in these patients.http://link.springer.com/article/10.1186/s12871-018-0602-9Cognitive dysfunctionSleep apneaIntravenous anesthesiaPreconditioning |
| spellingShingle | Soeren Wagner Joerg Quente Sven Staedtler Katharina Koch Tanja Richter-Schmidinger Johannes Kornhuber Harald Ihmsen Juergen Schuettler A high risk of sleep apnea is associated with less postoperative cognitive dysfunction after intravenous anesthesia: results of an observational pilot study BMC Anesthesiology Cognitive dysfunction Sleep apnea Intravenous anesthesia Preconditioning |
| title | A high risk of sleep apnea is associated with less postoperative cognitive dysfunction after intravenous anesthesia: results of an observational pilot study |
| title_full | A high risk of sleep apnea is associated with less postoperative cognitive dysfunction after intravenous anesthesia: results of an observational pilot study |
| title_fullStr | A high risk of sleep apnea is associated with less postoperative cognitive dysfunction after intravenous anesthesia: results of an observational pilot study |
| title_full_unstemmed | A high risk of sleep apnea is associated with less postoperative cognitive dysfunction after intravenous anesthesia: results of an observational pilot study |
| title_short | A high risk of sleep apnea is associated with less postoperative cognitive dysfunction after intravenous anesthesia: results of an observational pilot study |
| title_sort | high risk of sleep apnea is associated with less postoperative cognitive dysfunction after intravenous anesthesia results of an observational pilot study |
| topic | Cognitive dysfunction Sleep apnea Intravenous anesthesia Preconditioning |
| url | http://link.springer.com/article/10.1186/s12871-018-0602-9 |
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