GITR ligand fusion protein agonist enhances the tumor antigen–specific CD8 T-cell response and leads to long-lasting memory

GITR ligand fusion protein agonist enhances the tumor antigen–specific CD8 T-cell response and leads to long-lasting memory

Abstract Background The expansion of antigen-specific CD8 T cells is important in generating an effective and long-lasting immune response to tumors and viruses. Glucocorticoid-induced tumor necrosis factor receptor family-related receptor (GITR) is a co-stimulatory receptor that binds the GITR liga...

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Bibliographic Details
Main Authors: Nick M. Durham, Nick Holoweckyj, Randall S. MacGill, Kelly McGlinchey, Ching Ching Leow, Scott H. Robbins
Format: Article
Language:English
Published: BMJ Publishing Group 2017-06-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
GITRL-FP
GITR
T cell
Vaccine
CD8
Memory
Online Access:http://link.springer.com/article/10.1186/s40425-017-0247-0

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