Oleuropein Activates Neonatal Neocortical Proteasomes, but Proteasome Gene Targeting by AAV9 Is Variable in a Clinically Relevant Piglet Model of Brain Hypoxia-Ischemia and Hypothermia

Oleuropein Activates Neonatal Neocortical Proteasomes, but Proteasome Gene Targeting by AAV9 Is Variable in a Clinically Relevant Piglet Model of Brain Hypoxia-Ischemia and Hypothermia

Cerebral hypoxia-ischemia (HI) compromises the proteasome in a clinically relevant neonatal piglet model. Protecting and activating proteasomes could be an adjunct therapy to hypothermia. We investigated whether chymotrypsin-like proteasome activity differs regionally and developmentally in the neon...

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Bibliographic Details
Main Authors: Nagat El Demerdash, May W. Chen, Caitlin E. O’Brien, Shawn Adams, Ewa Kulikowicz, Lee J. Martin, Jennifer K. Lee
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cells
Subjects:
neonatal brain damage
hypoxia-ischemia
white matter injury
proteinopathy
conditional gene manipulation
hypothermia
Online Access:https://www.mdpi.com/2073-4409/10/8/2120

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