A Novel Protozoa Parasite-Derived Protein Adjuvant Is Effective in Immunization with Cancer Cells to Activate the Cancer-Specific Protective Immunity and Inhibit the Cancer Growth in a Murine Model of Colorectal Cancer

A Novel Protozoa Parasite-Derived Protein Adjuvant Is Effective in Immunization with Cancer Cells to Activate the Cancer-Specific Protective Immunity and Inhibit the Cancer Growth in a Murine Model of Colorectal Cancer

Cancer-specific CD8<sup>+</sup> cytotoxic T cells play important roles in preventing cancer growth, and IFN-γ, in addition to IL-12 and type I interferon, is critical for activating CD8<sup>+</sup> cytotoxic T cells. We recently identified the capability of the amino-terminus...

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Bibliographic Details
Main Authors: Rajesh Mani, Chloe G. Martin, Kanal E. Balu, Qingding Wang, Piotr Rychahou, Tadahide Izumi, B. Mark Evers, Yasuhiro Suzuki
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Cells
Subjects:
<i>Toxoplasma gondii</i>
protein adjuvant
cancer immunotherapy
CD8<sup>+</sup> T cells
cytotoxic activity
IFN-γ
Online Access:https://www.mdpi.com/2073-4409/13/2/111

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