Oncogenic pathway driven by p85β: upstream signals to activate p110
The phosphatidylinositol 3-kinase (PI3K), which is composed of the p85 regulatory and p110 catalytic subunits, is known to be downstream of the receptor tyrosine kinase (RTK). Our recent findings revealed that p85β increases the protein level of AXL (an RTK) to activate p110, suggesting bidirectiona...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-09-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2020.1780900 |
| _version_ | 1797677104283779072 |
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| author | Ling Rao Lydia W. T. Cheung |
| author_facet | Ling Rao Lydia W. T. Cheung |
| author_sort | Ling Rao |
| collection | DOAJ |
| description | The phosphatidylinositol 3-kinase (PI3K), which is composed of the p85 regulatory and p110 catalytic subunits, is known to be downstream of the receptor tyrosine kinase (RTK). Our recent findings revealed that p85β increases the protein level of AXL (an RTK) to activate p110, suggesting bidirectional regulation between PI3K and RTK. |
| first_indexed | 2024-03-11T22:40:11Z |
| format | Article |
| id | doaj.art-c043127adc0447cd8f7a3f51e5ba893a |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:40:11Z |
| publishDate | 2020-09-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-c043127adc0447cd8f7a3f51e5ba893a2023-09-22T09:11:02ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562020-09-017510.1080/23723556.2020.17809001780900Oncogenic pathway driven by p85β: upstream signals to activate p110Ling Rao0Lydia W. T. Cheung1The University of Hong KongThe University of Hong KongThe phosphatidylinositol 3-kinase (PI3K), which is composed of the p85 regulatory and p110 catalytic subunits, is known to be downstream of the receptor tyrosine kinase (RTK). Our recent findings revealed that p85β increases the protein level of AXL (an RTK) to activate p110, suggesting bidirectional regulation between PI3K and RTK.http://dx.doi.org/10.1080/23723556.2020.1780900pi3kp85axlautophagyprotein degradation |
| spellingShingle | Ling Rao Lydia W. T. Cheung Oncogenic pathway driven by p85β: upstream signals to activate p110 Molecular & Cellular Oncology pi3k p85 axl autophagy protein degradation |
| title | Oncogenic pathway driven by p85β: upstream signals to activate p110 |
| title_full | Oncogenic pathway driven by p85β: upstream signals to activate p110 |
| title_fullStr | Oncogenic pathway driven by p85β: upstream signals to activate p110 |
| title_full_unstemmed | Oncogenic pathway driven by p85β: upstream signals to activate p110 |
| title_short | Oncogenic pathway driven by p85β: upstream signals to activate p110 |
| title_sort | oncogenic pathway driven by p85β upstream signals to activate p110 |
| topic | pi3k p85 axl autophagy protein degradation |
| url | http://dx.doi.org/10.1080/23723556.2020.1780900 |
| work_keys_str_mv | AT lingrao oncogenicpathwaydrivenbyp85bupstreamsignalstoactivatep110 AT lydiawtcheung oncogenicpathwaydrivenbyp85bupstreamsignalstoactivatep110 |