Prevalence and predictors of developing vision-threatening diabetic retinopathy within the first three years of type 2 diabetes
PurposeTo investigate the prevalence of diabetic retinopathy (DR) and vision-threatening DR (VTDR) in patients with type 2 diabetes mellitus (T2DM) stratified by the duration of diabetes and to identify the clinical variations and risk factors for VTDR occurring at different stages of T2DM.MethodsTh...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1305378/full |
| _version_ | 1827578424461361152 |
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| author | Jia Yan Bo Li Ye Chen Chufeng Gu Guosheng Dai Qin Zhang Zhi Zheng Dawei Luo Shuzhi Zhao Chuandi Zhou |
| author_facet | Jia Yan Bo Li Ye Chen Chufeng Gu Guosheng Dai Qin Zhang Zhi Zheng Dawei Luo Shuzhi Zhao Chuandi Zhou |
| author_sort | Jia Yan |
| collection | DOAJ |
| description | PurposeTo investigate the prevalence of diabetic retinopathy (DR) and vision-threatening DR (VTDR) in patients with type 2 diabetes mellitus (T2DM) stratified by the duration of diabetes and to identify the clinical variations and risk factors for VTDR occurring at different stages of T2DM.MethodsThis was a retrospective comparative study. Patients were divided into short- (≤3 years), intermediate- (3–7 years), and long-duration (>7 years) groups. All patients were followed-up for DR and VTDR development. Risk factors were explored using logistic regression analysis.ResultsA total of,2961 patients were included; among them, 1,036 (35.0%) patients developed DR, and 293 (9.9%) had VTDR. The frequency of VTDR in patients who developed DR in the short-duration group was significantly higher than that in the intermediate-duration group (25.7% vs. 15.0%; p = 0.019), but comparable with that of the long-duration group (25.7% vs. 31.8%; p = 0.138). Patients who developed VTDR within the first 3 years of T2DM were more likely to have a family history of diabetes (p = 0.024), had higher glycated hemoglobin (p = 0.025), were males (p = 0.042), and were notably older at the onset of diabetes (p <0.001) but younger when diagnosed with DR (p <0.001). Moreover, higher glycated hemoglobin (OR = 1.14; 95% CI: 1.00–1.29; p = 0.043) and diabetic nephropathy (DN) (OR = 2.31; 95% CI: 1.08–4.91; p = 0.030) were independent risk factors for developing VTDR during the first 3 years of T2DM.ConclusionThe risk of DR is not high in persons with ≤3 years’ duration of T2DM, however, if afflicted, the risk of VTDR should never be neglected. More frequent retinal screening is warranted in patients with newly diagnosed T2DM. |
| first_indexed | 2024-03-08T21:46:21Z |
| format | Article |
| id | doaj.art-c0463817efcf419dbc3af6179c7037b9 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-08T21:46:21Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-c0463817efcf419dbc3af6179c7037b92023-12-20T09:03:53ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-12-011410.3389/fendo.2023.13053781305378Prevalence and predictors of developing vision-threatening diabetic retinopathy within the first three years of type 2 diabetesJia Yan0Bo Li1Ye Chen2Chufeng Gu3Guosheng Dai4Qin Zhang5Zhi Zheng6Dawei Luo7Shuzhi Zhao8Chuandi Zhou9Department of Ophthalmology, Taizhou Zhangqin Eye Hospital, Taizhou, ChinaDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, ChinaSurgical Department, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, ChinaDepartment of Ophthalmology, Taizhou Zhangqin Eye Hospital, Taizhou, ChinaDepartment of Ophthalmology, Taizhou Zhangqin Eye Hospital, Taizhou, ChinaDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, ChinaDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, ChinaDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, ChinaDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, ChinaPurposeTo investigate the prevalence of diabetic retinopathy (DR) and vision-threatening DR (VTDR) in patients with type 2 diabetes mellitus (T2DM) stratified by the duration of diabetes and to identify the clinical variations and risk factors for VTDR occurring at different stages of T2DM.MethodsThis was a retrospective comparative study. Patients were divided into short- (≤3 years), intermediate- (3–7 years), and long-duration (>7 years) groups. All patients were followed-up for DR and VTDR development. Risk factors were explored using logistic regression analysis.ResultsA total of,2961 patients were included; among them, 1,036 (35.0%) patients developed DR, and 293 (9.9%) had VTDR. The frequency of VTDR in patients who developed DR in the short-duration group was significantly higher than that in the intermediate-duration group (25.7% vs. 15.0%; p = 0.019), but comparable with that of the long-duration group (25.7% vs. 31.8%; p = 0.138). Patients who developed VTDR within the first 3 years of T2DM were more likely to have a family history of diabetes (p = 0.024), had higher glycated hemoglobin (p = 0.025), were males (p = 0.042), and were notably older at the onset of diabetes (p <0.001) but younger when diagnosed with DR (p <0.001). Moreover, higher glycated hemoglobin (OR = 1.14; 95% CI: 1.00–1.29; p = 0.043) and diabetic nephropathy (DN) (OR = 2.31; 95% CI: 1.08–4.91; p = 0.030) were independent risk factors for developing VTDR during the first 3 years of T2DM.ConclusionThe risk of DR is not high in persons with ≤3 years’ duration of T2DM, however, if afflicted, the risk of VTDR should never be neglected. More frequent retinal screening is warranted in patients with newly diagnosed T2DM.https://www.frontiersin.org/articles/10.3389/fendo.2023.1305378/fulltype 2 diabetesdiabetic retinopathyvision-threatening diabetic retinopathyrisk factorearly-onset retinopathy |
| spellingShingle | Jia Yan Bo Li Ye Chen Chufeng Gu Guosheng Dai Qin Zhang Zhi Zheng Dawei Luo Shuzhi Zhao Chuandi Zhou Prevalence and predictors of developing vision-threatening diabetic retinopathy within the first three years of type 2 diabetes Frontiers in Endocrinology type 2 diabetes diabetic retinopathy vision-threatening diabetic retinopathy risk factor early-onset retinopathy |
| title | Prevalence and predictors of developing vision-threatening diabetic retinopathy within the first three years of type 2 diabetes |
| title_full | Prevalence and predictors of developing vision-threatening diabetic retinopathy within the first three years of type 2 diabetes |
| title_fullStr | Prevalence and predictors of developing vision-threatening diabetic retinopathy within the first three years of type 2 diabetes |
| title_full_unstemmed | Prevalence and predictors of developing vision-threatening diabetic retinopathy within the first three years of type 2 diabetes |
| title_short | Prevalence and predictors of developing vision-threatening diabetic retinopathy within the first three years of type 2 diabetes |
| title_sort | prevalence and predictors of developing vision threatening diabetic retinopathy within the first three years of type 2 diabetes |
| topic | type 2 diabetes diabetic retinopathy vision-threatening diabetic retinopathy risk factor early-onset retinopathy |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1305378/full |
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