Saccharomyces cerevisiae DJ-1 paralogs maintain genome integrity through glycation repair of nucleic acids and proteins

Saccharomyces cerevisiae DJ-1 paralogs maintain genome integrity through glycation repair of nucleic acids and proteins

Reactive carbonyl species (RCS) such as methylglyoxal and glyoxal are potent glycolytic intermediates that extensively damage cellular biomolecules leading to genetic aberration and protein misfolding. Hence, RCS levels are crucial indicators in the progression of various pathological diseases. Besi...

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Bibliographic Details
Main Authors: Gautam Susarla, Priyanka Kataria, Amrita Kundu, Patrick D'Silva
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-08-01
Series:eLife
Subjects:
yeast Hsp31
DJ-1 family proteins
DNA glycation
deglycation repair
mitochondrial glycation
mitochondrial dysfunction
Online Access:https://elifesciences.org/articles/88875

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