The effect of long-term feeding of skin barrier-fortified diets on the owner-assessed incidence of atopic dermatitis symptoms in Labrador retrievers
We investigated the effect of feeding a skin barrier function-augmenting diet early in dogs' lives on the appearance of clinical signs associated with canine atopic dermatitis. Pregnant bitches (starting 5 weeks after mating) and their subsequent litters (up to 1 year of age) were fed either su...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2015-01-01
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| Series: | Journal of Nutritional Science |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S2048679014000615/type/journal_article |
| _version_ | 1811156015731703808 |
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| author | Frank Looringh van Beeck Adrian Watson Margriet Bos Vincent Biourge Ton Willemse |
| author_facet | Frank Looringh van Beeck Adrian Watson Margriet Bos Vincent Biourge Ton Willemse |
| author_sort | Frank Looringh van Beeck |
| collection | DOAJ |
| description | We investigated the effect of feeding a skin barrier function-augmenting diet early in dogs' lives on the appearance of clinical signs associated with canine atopic dermatitis. Pregnant bitches (starting 5 weeks after mating) and their subsequent litters (up to 1 year of age) were fed either supplemented or unsupplemented diets. Nutrients supplemented were nicotinamide, pantothenate, histidine, inositol and choline. Circulating IgE levels to dust mute allergens Der f and Der p were measured when the puppies were 6 and 12 months old. Two owner questionnaires were used to assess the occurrence of typical signs associated with atopic dermatitis when dogs were between the ages of 22 and 36, and 34 and 48 months. Using linear mixed models we observed higher levels of circulating anti-Der f (P = 0·021) and -Der p IgE (P = 0·01) during the first year in the dogs fed the unsupplemented than in those fed the supplemented diet. The owner-assessed incidence of atopic dermatitis signs amongst the dogs was significantly greater in the unsupplemented group at the time of the second follow-up questionnaire (10/33 dogs v. 2/24 dogs). These outcomes suggest that a nutritionally derived improvement to barrier function early in life may reduce the frequency of signs associated with atopic dermatitis. The effect is possibly the result of making the epidermis, now thought to be a major route of environmental allergen exposure, more resistant to penetration. |
| first_indexed | 2024-04-10T04:44:19Z |
| format | Article |
| id | doaj.art-c04878ddffd04eeca475d04ee1196865 |
| institution | Directory Open Access Journal |
| issn | 2048-6790 |
| language | English |
| last_indexed | 2024-04-10T04:44:19Z |
| publishDate | 2015-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Nutritional Science |
| spelling | doaj.art-c04878ddffd04eeca475d04ee11968652023-03-09T12:38:43ZengCambridge University PressJournal of Nutritional Science2048-67902015-01-01410.1017/jns.2014.61The effect of long-term feeding of skin barrier-fortified diets on the owner-assessed incidence of atopic dermatitis symptoms in Labrador retrieversFrank Looringh van Beeck0Adrian Watson1Margriet Bos2Vincent Biourge3Ton Willemse4Department of Clinical Sciences of Companion Animals and Division of Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The NetherlandsRoyal Canin SAS© , Aimargues, FranceRoyal Canin, Veghel, The NetherlandsRoyal Canin SAS© , Aimargues, FranceDepartment of Clinical Sciences of Companion Animals and Division of Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The NetherlandsWe investigated the effect of feeding a skin barrier function-augmenting diet early in dogs' lives on the appearance of clinical signs associated with canine atopic dermatitis. Pregnant bitches (starting 5 weeks after mating) and their subsequent litters (up to 1 year of age) were fed either supplemented or unsupplemented diets. Nutrients supplemented were nicotinamide, pantothenate, histidine, inositol and choline. Circulating IgE levels to dust mute allergens Der f and Der p were measured when the puppies were 6 and 12 months old. Two owner questionnaires were used to assess the occurrence of typical signs associated with atopic dermatitis when dogs were between the ages of 22 and 36, and 34 and 48 months. Using linear mixed models we observed higher levels of circulating anti-Der f (P = 0·021) and -Der p IgE (P = 0·01) during the first year in the dogs fed the unsupplemented than in those fed the supplemented diet. The owner-assessed incidence of atopic dermatitis signs amongst the dogs was significantly greater in the unsupplemented group at the time of the second follow-up questionnaire (10/33 dogs v. 2/24 dogs). These outcomes suggest that a nutritionally derived improvement to barrier function early in life may reduce the frequency of signs associated with atopic dermatitis. The effect is possibly the result of making the epidermis, now thought to be a major route of environmental allergen exposure, more resistant to penetration.https://www.cambridge.org/core/product/identifier/S2048679014000615/type/journal_articleCanine nutritionBarrier functionAtopic dermatitis |
| spellingShingle | Frank Looringh van Beeck Adrian Watson Margriet Bos Vincent Biourge Ton Willemse The effect of long-term feeding of skin barrier-fortified diets on the owner-assessed incidence of atopic dermatitis symptoms in Labrador retrievers Journal of Nutritional Science Canine nutrition Barrier function Atopic dermatitis |
| title | The effect of long-term feeding of skin barrier-fortified diets on the owner-assessed incidence of atopic dermatitis symptoms in Labrador retrievers |
| title_full | The effect of long-term feeding of skin barrier-fortified diets on the owner-assessed incidence of atopic dermatitis symptoms in Labrador retrievers |
| title_fullStr | The effect of long-term feeding of skin barrier-fortified diets on the owner-assessed incidence of atopic dermatitis symptoms in Labrador retrievers |
| title_full_unstemmed | The effect of long-term feeding of skin barrier-fortified diets on the owner-assessed incidence of atopic dermatitis symptoms in Labrador retrievers |
| title_short | The effect of long-term feeding of skin barrier-fortified diets on the owner-assessed incidence of atopic dermatitis symptoms in Labrador retrievers |
| title_sort | effect of long term feeding of skin barrier fortified diets on the owner assessed incidence of atopic dermatitis symptoms in labrador retrievers |
| topic | Canine nutrition Barrier function Atopic dermatitis |
| url | https://www.cambridge.org/core/product/identifier/S2048679014000615/type/journal_article |
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