Evaluation of Candida bloodstream infection and antifungal utilization in a tertiary care hospital
Abstract Background Candida bloodstream infections carry a significant mortality risk, justifying the importance of adequate antifungal therapy. This study describes trends in antifungal consumption using the Defined Daily Dose (DDD) and Days of Therapy (DOT) metrics, identifies the microbiological...
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| Format: | Article |
| Language: | English |
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BMC
2018-04-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | http://link.springer.com/article/10.1186/s12879-018-3094-9 |
| _version_ | 1818340193998995456 |
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| author | Tatiana Aporta Marins Alexandre R. Marra Michael B. Edmond Marines Dalla Valle Martino Paula Kiyomi Onaga Yokota Ana Carolina Cintra Nunes Mafra Marcelino Souza Durão Junior |
| author_facet | Tatiana Aporta Marins Alexandre R. Marra Michael B. Edmond Marines Dalla Valle Martino Paula Kiyomi Onaga Yokota Ana Carolina Cintra Nunes Mafra Marcelino Souza Durão Junior |
| author_sort | Tatiana Aporta Marins |
| collection | DOAJ |
| description | Abstract Background Candida bloodstream infections carry a significant mortality risk, justifying the importance of adequate antifungal therapy. This study describes trends in antifungal consumption using the Defined Daily Dose (DDD) and Days of Therapy (DOT) metrics, identifies the microbiological profile, the time to initiation of empirical therapy, the adjustment after positive blood culture results for Candida, and the impact on in-hospital mortality rate in patients with candidemia. Methods An analysis of antifungal consumption from 2008 to 2016, and of candidemia cases from 2012 to 2016 was carried out in a private tertiary hospital. Results A total of 11,273 admissions were identified with a prescription for at least one type of antifungal therapy. Fluconazole was the most prescribed antifungal drug in terms of general consumption. Through the DDD and DOT metrics, we observed that over time, there was an increase in the consumption of liposomal amphotericin B, micafungin and voriconazole. Candida albicans was the most isolated species in blood cultures. Regarding candidemia, we analyzed samples from 115 patients. Empirical therapy was started within 24 h of blood culture in 44.3% of the cases, and in 81.7% of the cases, the antifungal was deemed to be adequate based in antifungal susceptibility testing, both of which were not associated with the in-hospital mortality rate. Conclusions Our study reinforces the importance of monitoring the consumption of antifungal agents, which helps in proposing actions that lead to their rational use and, consequently, reduces the appearance of resistant strains. |
| first_indexed | 2024-12-13T15:39:01Z |
| format | Article |
| id | doaj.art-c049c0be83604972a7bf35e364ccff00 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-13T15:39:01Z |
| publishDate | 2018-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-c049c0be83604972a7bf35e364ccff002022-12-21T23:39:53ZengBMCBMC Infectious Diseases1471-23342018-04-0118111310.1186/s12879-018-3094-9Evaluation of Candida bloodstream infection and antifungal utilization in a tertiary care hospitalTatiana Aporta Marins0Alexandre R. Marra1Michael B. Edmond2Marines Dalla Valle Martino3Paula Kiyomi Onaga Yokota4Ana Carolina Cintra Nunes Mafra5Marcelino Souza Durão Junior6Hospital Israelita Albert EinsteinDivision of Medical Practice, Hospital Israelita Albert EinsteinOffice of Clinical Quality, Safety and Performance Improvement, University of Iowa Hospitals and ClinicsClinical Laboratory, Hospital Israelita Albert EinsteinDivision of Medical Practice, Hospital Israelita Albert EinsteinInstituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert EinsteinDivision of Medical Practice, Hospital Israelita Albert EinsteinAbstract Background Candida bloodstream infections carry a significant mortality risk, justifying the importance of adequate antifungal therapy. This study describes trends in antifungal consumption using the Defined Daily Dose (DDD) and Days of Therapy (DOT) metrics, identifies the microbiological profile, the time to initiation of empirical therapy, the adjustment after positive blood culture results for Candida, and the impact on in-hospital mortality rate in patients with candidemia. Methods An analysis of antifungal consumption from 2008 to 2016, and of candidemia cases from 2012 to 2016 was carried out in a private tertiary hospital. Results A total of 11,273 admissions were identified with a prescription for at least one type of antifungal therapy. Fluconazole was the most prescribed antifungal drug in terms of general consumption. Through the DDD and DOT metrics, we observed that over time, there was an increase in the consumption of liposomal amphotericin B, micafungin and voriconazole. Candida albicans was the most isolated species in blood cultures. Regarding candidemia, we analyzed samples from 115 patients. Empirical therapy was started within 24 h of blood culture in 44.3% of the cases, and in 81.7% of the cases, the antifungal was deemed to be adequate based in antifungal susceptibility testing, both of which were not associated with the in-hospital mortality rate. Conclusions Our study reinforces the importance of monitoring the consumption of antifungal agents, which helps in proposing actions that lead to their rational use and, consequently, reduces the appearance of resistant strains.http://link.springer.com/article/10.1186/s12879-018-3094-9AntifungalCandidemiaConsumptionDefined daily doseDays of therapy |
| spellingShingle | Tatiana Aporta Marins Alexandre R. Marra Michael B. Edmond Marines Dalla Valle Martino Paula Kiyomi Onaga Yokota Ana Carolina Cintra Nunes Mafra Marcelino Souza Durão Junior Evaluation of Candida bloodstream infection and antifungal utilization in a tertiary care hospital BMC Infectious Diseases Antifungal Candidemia Consumption Defined daily dose Days of therapy |
| title | Evaluation of Candida bloodstream infection and antifungal utilization in a tertiary care hospital |
| title_full | Evaluation of Candida bloodstream infection and antifungal utilization in a tertiary care hospital |
| title_fullStr | Evaluation of Candida bloodstream infection and antifungal utilization in a tertiary care hospital |
| title_full_unstemmed | Evaluation of Candida bloodstream infection and antifungal utilization in a tertiary care hospital |
| title_short | Evaluation of Candida bloodstream infection and antifungal utilization in a tertiary care hospital |
| title_sort | evaluation of candida bloodstream infection and antifungal utilization in a tertiary care hospital |
| topic | Antifungal Candidemia Consumption Defined daily dose Days of therapy |
| url | http://link.springer.com/article/10.1186/s12879-018-3094-9 |
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