In silico and in vitro inhibition of host-based viral entry targets and cytokine storm in COVID-19 by ginsenoside compound K

In silico and in vitro inhibition of host-based viral entry targets and cytokine storm in COVID-19 by ginsenoside compound K

SARS-CoV-2 is a novel coronavirus that emerged as an epidemic, causing a respiratory disease with multiple severe symptoms and deadly consequences. ACE-2 and TMPRSS2 play crucial and synergistic roles in the membrane fusion and viral entry of SARS-CoV-2 (COVID-19). The spike (S) protein of SARS-CoV-...

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Bibliographic Details
Main Authors: Vinothini Boopathi, Jinnatun Nahar, Mohanapriya Murugesan, Sathiyamoorthy Subramaniyam, Byoung Man Kong, Sung-Keun Choi, Chang-Soon Lee, Li Ling, Dong Uk Yang, Deok Chun Yang, Ramya Mathiyalagan, Se Chan Kang
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Heliyon
Subjects:
Ginsenoside
Compound K
ACE-2
TMPRSS2
Molecular docking
Molecular dynamics simulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023065490

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