High Estimated Glomerular Filtration Rate Is Associated With Worse Cognitive Performance in the Hypertensive Population: Results From the China H-Type Hypertension Registry Study
BackgroundIncreasing studies have focused on the predictive value of high estimated glomerular filtration rate (eGFR) on cardiovascular diseases and mortality; however, the association between high eGFR with cognitive function is still not established. Thus, this study aimed to determine the co-rela...
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| Format: | Article |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2021.706928/full |
| _version_ | 1818293849975422976 |
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| author | Junpei Li Shichao Yu Ziheng Tan Yun Yu Linfei Luo Wei Zhou Wei Zhou Linjuan Zhu Linjuan Zhu Tao Wang Tao Wang Tianyu Cao Jianglong Tu Huihui Bao Huihui Bao Xiao Huang Xiaoshu Cheng Xiaoshu Cheng |
| author_facet | Junpei Li Shichao Yu Ziheng Tan Yun Yu Linfei Luo Wei Zhou Wei Zhou Linjuan Zhu Linjuan Zhu Tao Wang Tao Wang Tianyu Cao Jianglong Tu Huihui Bao Huihui Bao Xiao Huang Xiaoshu Cheng Xiaoshu Cheng |
| author_sort | Junpei Li |
| collection | DOAJ |
| description | BackgroundIncreasing studies have focused on the predictive value of high estimated glomerular filtration rate (eGFR) on cardiovascular diseases and mortality; however, the association between high eGFR with cognitive function is still not established. Thus, this study aimed to determine the co-relationship between high eGFR and cognitive performance in the hypertensive population.MethodsWe conducted a baseline cross-sectional study using data from the China H-type Hypertension Registry study. Mini-Mental State Examination (MMSE) assessment was performed to evaluate the cognitive function scale, and serum creatinine was collected to estimate eGFR level. Different MMSE cutoff values were applied in participants with the various educational background to define dementia: <24 in participants with secondary school and above education setting, <20 in those with primary school, and <17 in illiterate participants.ResultsA total of 9,527 hypertensive adults with mean age 63.7 ± 9.8 years and 67% female gender were analyzed. The eGFR cutoff value of 71.52 ml/min/1.73 m2 was found after adjusting for potential covariates in a threshold effect analysis. The MMSE increased significantly with the increment of eGFR (β, 0.27; 95% CI: 0.12–0.41) in participants with eGFR < 71.52 ml/min/1.73 m2 and decreased (β, −0.28; 95% CI: −0.39 to −0.17) in participants with eGFR ≥ 71.52 ml/min/1.73 m2. Individuals with eGFR ≥ 85 ml/min/1.73 m2 have an elevated risk of cognitive impairment than those with eGFR of 65–75 ml/min/1.73 m2. Subgroup analysis showed that a greater reduction degree of MMSE was observed in female individuals and those who had body mass index (BMI) ≥ 24 kg/m2 among participants with eGFR ≥ 71.52 ml/min/1.73 m2.ConclusionOur findings observed an inverted U-shaped relationship between eGFR and cognitive function. Both the low and high levels of eGFR were independently associated with worse cognitive assessment in the hypertensive population. |
| first_indexed | 2024-12-13T03:22:24Z |
| format | Article |
| id | doaj.art-c049ea877fc54fd994cc507ed29c9ad1 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-13T03:22:24Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-c049ea877fc54fd994cc507ed29c9ad12022-12-22T00:01:20ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-02-011310.3389/fnagi.2021.706928706928High Estimated Glomerular Filtration Rate Is Associated With Worse Cognitive Performance in the Hypertensive Population: Results From the China H-Type Hypertension Registry StudyJunpei Li0Shichao Yu1Ziheng Tan2Yun Yu3Linfei Luo4Wei Zhou5Wei Zhou6Linjuan Zhu7Linjuan Zhu8Tao Wang9Tao Wang10Tianyu Cao11Jianglong Tu12Huihui Bao13Huihui Bao14Xiao Huang15Xiaoshu Cheng16Xiaoshu Cheng17Department of Cardiovascular, Nanchang University Second Affiliated Hospital, Nanchang, ChinaQinghua Health Center, Nanyang, ChinaDepartment of Cardiovascular, Nanchang University Second Affiliated Hospital, Nanchang, ChinaDepartment of Cardiovascular, Nanchang University Second Affiliated Hospital, Nanchang, ChinaDepartment of Cardiovascular, Nanchang University Second Affiliated Hospital, Nanchang, ChinaDepartment of Cardiovascular, Nanchang University Second Affiliated Hospital, Nanchang, ChinaCenter for Prevention and Treatment of Cardiovascular Diseases, Nanchang University Second Affiliated Hospital, Nanchang, ChinaDepartment of Cardiovascular, Nanchang University Second Affiliated Hospital, Nanchang, ChinaCenter for Prevention and Treatment of Cardiovascular Diseases, Nanchang University Second Affiliated Hospital, Nanchang, ChinaDepartment of Cardiovascular, Nanchang University Second Affiliated Hospital, Nanchang, ChinaCenter for Prevention and Treatment of Cardiovascular Diseases, Nanchang University Second Affiliated Hospital, Nanchang, ChinaDepartment of Biological Anthropology, University of California, Santa Barbara, Santa Barbara, CA, United StatesDepartment of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Cardiovascular, Nanchang University Second Affiliated Hospital, Nanchang, ChinaCenter for Prevention and Treatment of Cardiovascular Diseases, Nanchang University Second Affiliated Hospital, Nanchang, ChinaDepartment of Cardiovascular, Nanchang University Second Affiliated Hospital, Nanchang, ChinaDepartment of Cardiovascular, Nanchang University Second Affiliated Hospital, Nanchang, ChinaCenter for Prevention and Treatment of Cardiovascular Diseases, Nanchang University Second Affiliated Hospital, Nanchang, ChinaBackgroundIncreasing studies have focused on the predictive value of high estimated glomerular filtration rate (eGFR) on cardiovascular diseases and mortality; however, the association between high eGFR with cognitive function is still not established. Thus, this study aimed to determine the co-relationship between high eGFR and cognitive performance in the hypertensive population.MethodsWe conducted a baseline cross-sectional study using data from the China H-type Hypertension Registry study. Mini-Mental State Examination (MMSE) assessment was performed to evaluate the cognitive function scale, and serum creatinine was collected to estimate eGFR level. Different MMSE cutoff values were applied in participants with the various educational background to define dementia: <24 in participants with secondary school and above education setting, <20 in those with primary school, and <17 in illiterate participants.ResultsA total of 9,527 hypertensive adults with mean age 63.7 ± 9.8 years and 67% female gender were analyzed. The eGFR cutoff value of 71.52 ml/min/1.73 m2 was found after adjusting for potential covariates in a threshold effect analysis. The MMSE increased significantly with the increment of eGFR (β, 0.27; 95% CI: 0.12–0.41) in participants with eGFR < 71.52 ml/min/1.73 m2 and decreased (β, −0.28; 95% CI: −0.39 to −0.17) in participants with eGFR ≥ 71.52 ml/min/1.73 m2. Individuals with eGFR ≥ 85 ml/min/1.73 m2 have an elevated risk of cognitive impairment than those with eGFR of 65–75 ml/min/1.73 m2. Subgroup analysis showed that a greater reduction degree of MMSE was observed in female individuals and those who had body mass index (BMI) ≥ 24 kg/m2 among participants with eGFR ≥ 71.52 ml/min/1.73 m2.ConclusionOur findings observed an inverted U-shaped relationship between eGFR and cognitive function. Both the low and high levels of eGFR were independently associated with worse cognitive assessment in the hypertensive population.https://www.frontiersin.org/articles/10.3389/fnagi.2021.706928/fullestimated glomerular filtration rate (eGFR)cognitive functionmini-mental state examination (MMSE)hypertensionU-shaped |
| spellingShingle | Junpei Li Shichao Yu Ziheng Tan Yun Yu Linfei Luo Wei Zhou Wei Zhou Linjuan Zhu Linjuan Zhu Tao Wang Tao Wang Tianyu Cao Jianglong Tu Huihui Bao Huihui Bao Xiao Huang Xiaoshu Cheng Xiaoshu Cheng High Estimated Glomerular Filtration Rate Is Associated With Worse Cognitive Performance in the Hypertensive Population: Results From the China H-Type Hypertension Registry Study Frontiers in Aging Neuroscience estimated glomerular filtration rate (eGFR) cognitive function mini-mental state examination (MMSE) hypertension U-shaped |
| title | High Estimated Glomerular Filtration Rate Is Associated With Worse Cognitive Performance in the Hypertensive Population: Results From the China H-Type Hypertension Registry Study |
| title_full | High Estimated Glomerular Filtration Rate Is Associated With Worse Cognitive Performance in the Hypertensive Population: Results From the China H-Type Hypertension Registry Study |
| title_fullStr | High Estimated Glomerular Filtration Rate Is Associated With Worse Cognitive Performance in the Hypertensive Population: Results From the China H-Type Hypertension Registry Study |
| title_full_unstemmed | High Estimated Glomerular Filtration Rate Is Associated With Worse Cognitive Performance in the Hypertensive Population: Results From the China H-Type Hypertension Registry Study |
| title_short | High Estimated Glomerular Filtration Rate Is Associated With Worse Cognitive Performance in the Hypertensive Population: Results From the China H-Type Hypertension Registry Study |
| title_sort | high estimated glomerular filtration rate is associated with worse cognitive performance in the hypertensive population results from the china h type hypertension registry study |
| topic | estimated glomerular filtration rate (eGFR) cognitive function mini-mental state examination (MMSE) hypertension U-shaped |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2021.706928/full |
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