Th1 polarization defines the synovial fluid T cell compartment in oligoarticular juvenile idiopathic arthritis

Th1 polarization defines the synovial fluid T cell compartment in oligoarticular juvenile idiopathic arthritis

Oligoarticular juvenile idiopathic arthritis (oligo JIA) is the most common form of chronic inflammatory arthritis in children, yet the cause of this disease remains unknown. To understand immune responses in oligo JIA, we immunophenotyped synovial fluid T cells with flow cytometry, bulk RNA-Seq, si...

Full description

Bibliographic Details
Main Authors:	Amélie M. Julé, Kacie J. Hoyt, Kevin Wei, Maria Gutierrez-Arcelus, Maria L. Taylor, Julie Ng, James A. Lederer, Siobhan M. Case, Margaret H. Chang, Ezra M. Cohen, Fatma Dedeoglu, Melissa M. Hazen, Jonathan S. Hausmann, Olha Halyabar, Erin Janssen, Jeffrey Lo, Mindy S. Lo, Esra Meidan, Jordan E. Roberts, Mary Beth F. Son, Robert P. Sundel, Pui Y. Lee, Talal Chatila, Peter A. Nigrovic, Lauren A. Henderson
Format:	Article
Language:	English
Published:	American Society for Clinical investigation 2021-09-01
Series:	JCI Insight
Subjects:	Autoimmunity Immunology
Online Access:	https://doi.org/10.1172/jci.insight.149185

Similar Items

Disordered T cell-B cell interactions in autoantibody-positive inflammatory arthritis
by: Amélie M. Julé, et al.
Published: (2023-01-01)

Synovial fibroblasts from children with oligoarticular juvenile idiopathic arthritis induce migration and prolong viability of neutrophils
by: Tobias Schmidt, et al.
Published: (2024-07-01)

Inhibition of interleukin-17 in patients with oligoarticular psoriatic arthritis
by: Ogdie, A, et al.
Published: (2023)

Natural autoimmunity in oligoarticular juvenile idiopathic arthritis
by: Elena Tsitsami, et al.
Published: (2023-05-01)

Proteomic profiling of extracellular vesicles in synovial fluid and plasma from Oligoarticular Juvenile Idiopathic Arthritis patients reveals novel immunopathogenic biomarkers
by: Federica Raggi, et al.
Published: (2023-04-01)

USE OF ETANERCEPT IN PATIENTS WITH OLIGOARTICULAR JUVENILE IDIOPATHIC ARTHRITIS
by: Т. М. Bzarova, et al.
Published: (2014-12-01)

Inhibition of Interleukin-17 in Patients with Oligoarticular Psoriatic Arthritis
by: Alexis Ogdie, et al.
Published: (2023-05-01)

Oligoarticular juvenile idiopathic arthritis among Saudi children
by: Mohammed Mustafa Moued, et al.
Published: (2013-11-01)

14.4 Oligoarticular Juvenile Idiopathic Arthritis (JIA): can extension be predicted?
by: Hunter PJ, et al.
Published: (2008-09-01)

Retrospective analysis of the effectiveness of local corticosteroid therapy in children with oligoarticular juvenile idiopathic arthritis
by: A. N. Kozhevnikov, et al.
Published: (2021-07-01)

RE: Oligoarticular juvenile idiopathic arthritis among Saudi children
by: Mahmood D. Al-Mendalawi
Published: (2014-03-01)

EXPERIENCE OF USING METHOTREXATE IN A PATIENT WITH EARLY OLIGOARTICULAR JUVENILE IDIOPATHIC ARTHRITIS
by: T. V. Sleptsova, et al.
Published: (2013-04-01)

Th17 and Th1 Lymphocytes in Oligoarticular Juvenile Idiopathic Arthritis
by: Laura Maggi, et al.
Published: (2019-03-01)

Uveitis in patients with oligoarticular juvenile idiopathic arthritis and juvenile spondyloarthritis/enthesitis related arthritis: is there any difference?
by: A. Martins, et al.
Published: (2023-05-01)

Predictors of methotrexate response in Turkish children with oligoarticular and polyarticular juvenile idiopathic arthritis
by: Ezgi Deniz Batu, et al.
Published: (2017-02-01)

Extended oligoarticular juvenile idiopathic arthritis with multiple enchondromatosis: A case report
by: Aydan Yekedüz Bülbül, et al.
Published: (2023-06-01)

Intra-articular corticosteroid therapy in oligoarticular juvenile arthritis: our clinical experience
by: Caff G, et al.
Published: (2011-09-01)

Treatment of early oligoarticular psoriatic arthritis with apremilast: primary outcomes at week 16 from the FOREMOST randomised controlled trial
by: Gossec, L, et al.
Published: (2024)

Identification of key biomarkers in RF-negative polyarticular and oligoarticular juvenile idiopathic arthritis by bioinformatic analysis
by: Yun Liu, et al.
Published: (2023-11-01)

Adalimumab Effectively Decreases Inflammation Downstream of TNFα Signaling in Synoviocytes from Extended Oligoarticular Juvenile Idiopathic Arthritis
by: Megan M. Simonds, et al.
Published: (2023-12-01)

Type I interferon signature and cycling lymphocytes in macrophage activation syndrome
by: Zhengping Huang, et al.
Published: (2023-11-01)

Superior oblique tendon (Brown’s) syndrome as the presenting finding in childhood onset HLA-B27-related enthesitis and juvenile idiopathic oligoarticular arthritis
by: C. Pham, et al.
Published: (2014-11-01)

Pragmatic Management of Hand Involvement in Extended Oligoarticular Juvenile Idiopathic Arthritis: Ultrasound-guided Serial Interphalangeal Joint Injections
by: İsa Cüce, et al.
Published: (2023-06-01)

Identification of a Novel Primary Atopic Disorder due to STAT6 Gain-of-Function Mutations
by: Safa Barış, et al.
Published: (2024-04-01)

Tracing the Spectrum of Inborn Errors of Immunity from Past to Present
by: Safa Barış, et al.
Published: (2024-04-01)

Extracellular vesicle‐derived microRNAs as potential biomarkers in oligoarticular juvenile idiopathic arthritis patients: methodological challenges and new perspectives
by: Federica Raggi, et al.
Published: (2022-10-01)

Development of a Screening Algorithm for Lung Disease in Systemic Juvenile Idiopathic Arthritis
by: Holly Wobma, et al.
Published: (2023-10-01)

Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures.
by: Sacre, S, et al.
Published: (2008)

Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures
by: Sacre, S, et al.
Published: (2009)

Microvesicles shed by oligodendroglioma cells and rheumatoid synovial fibroblasts contain aggrecanase activity
by: Lo Cicero, A, et al.
Published: (2012)

Microvesicles shed by oligodendroglioma cells and rheumatoid synovial fibroblasts contain aggrecanase activity.
by: Lo Cicero, A, et al.
Published: (2012)

Increased neutrophil extracellular trap formation in oligoarticular, polyarticular juvenile idiopathic arthritis and enthesitis-related arthritis: biomarkers for diagnosis and disease activity
by: Hongxia Tang, et al.
Published: (2024-08-01)

Neutrophils extracellular traps formation may serve as a biomarker for disease activity in oligoarticular juvenile idiopathic arthritis: a pilot study
by: Merav Heshin-Bekenstein, et al.
Published: (2023-07-01)

Synovial sarcoma of the tongue : Report of the case
by: S. Ghodsi, et al.
Published: (1974-07-01)

Diagnostic Potential of the Synovial Fluid
by: V. Schwartzová, et al.
Published: (2018-09-01)

Primary renal synovial sarcoma
by: Girish D. Bakhshi, et al.
Published: (2012-03-01)

Hip synovial chondromatosis. Arthroscopic treatment
by: Fernando M. Comba, et al.
Published: (2014-08-01)

FOXP3 expression in blood, synovial fluid and synovial tissue during inflammatory arthritis and intra-articular corticosteroid treatment.
by: Raghavan, S, et al.
Published: (2009)

Radiological features of knee joint synovial chondromatosis
by: E. Boninsegna, et al.
Published: (2019-07-01)

Synovial chondrosarcoma arising from synovial chondromatosis of the knee
by: MS Yao, et al.
Published: (2012-11-01)