External Evaluation of Population Pharmacokinetic Models of Methotrexate for Model-Informed Precision Dosing in Pediatric Patients with Acute Lymphoid Leukemia
Background: Methotrexate (MTX) is a key immunosuppressant for children with acute lymphoid leukemia (ALL), and it has a narrow therapeutic window and relatively high pharmacokinetic variability. Several population pharmacokinetic (PopPK) models of MTX in ALL children have been reported, but the vali...
| Main Authors: | , , , , |
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| 格式: | 文件 |
| 语言: | English |
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MDPI AG
2023-02-01
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| 丛编: | Pharmaceutics |
| 主题: | |
| 在线阅读: | https://www.mdpi.com/1999-4923/15/2/569 |