The influence of vitamin D supplementation and strength training on health biomarkers and chromosomal damage in community-dwelling older adults
Older adults lack of proper physical activity which is often accompanied by vitamin D deficiency. Those factors are known to contribute to health issues in the later years of life. The main goal of this intervention study was to investigate the effect of different vitamin D supplementation strategie...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-05-01
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| Series: | Redox Biology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231723000411 |
| _version_ | 1811154736358883328 |
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| author | Agnes Draxler Bernhard Franzke Sanja Kelecevic Alexander Maier Jelena Pantic Simon Srienc Katharina Cellnigg Scoris-Marian Solomon Carina Zötsch Rudolf Aschauer Sandra Unterberger Patrick A. Zöhrer Laura Bragagna Eva-Maria Strasser Barbara Wessner Karl-Heinz Wagner |
| author_facet | Agnes Draxler Bernhard Franzke Sanja Kelecevic Alexander Maier Jelena Pantic Simon Srienc Katharina Cellnigg Scoris-Marian Solomon Carina Zötsch Rudolf Aschauer Sandra Unterberger Patrick A. Zöhrer Laura Bragagna Eva-Maria Strasser Barbara Wessner Karl-Heinz Wagner |
| author_sort | Agnes Draxler |
| collection | DOAJ |
| description | Older adults lack of proper physical activity which is often accompanied by vitamin D deficiency. Those factors are known to contribute to health issues in the later years of life. The main goal of this intervention study was to investigate the effect of different vitamin D supplementation strategies for 4 weeks solely or combined with a 10-week strength training program on chromosomal stability in peripheral blood mononuclear cells in community-dwelling older people. One hundred women and men (65–85 years) received either vitamin D3 daily (800 IU), a monthly dose (50.000 IU) or placebo for 17 weeks. All groups received 400 mg calcium daily. The fitness status of the study participants was measured using the 30- second chair stand test, the handgrip strength test and the 6-min walk test. The cytokinesis block micronucleus cytome (CBMN) assay was applied to analyze chromosomal anomalies, including cytotoxic and genotoxic parameters. Changes in antioxidant markers were measured in plasma.Walking distance and chair stand performance improved significantly. Increased levels of the parameters of the CBMN assay were detected for all intervention groups at study end. At baseline micronuclei (MNi) frequency correlated significantly with BMI in both sexes (females: r = 0.369, p = 0.034; males: r = 0.265, p = 0.035), but not with vitamin D serum levels. In females, body fat (r = 0.372, p < 0.001) and functional parameter using the 30-s chair stand test (r = 0.311, p = 0.002) correlated significantly with MNi frequency. Interestingly, not vitamin D supplementation but 10 weeks of resistance training increased MNi frequency indicating elevated chromosomal instability and also adverse effects on antioxidant markers including glutathione and FRAP were detected in the group of community-dwelling older adults. |
| first_indexed | 2024-04-10T04:22:06Z |
| format | Article |
| id | doaj.art-c04cea351cea49b7ad1718ff026ad824 |
| institution | Directory Open Access Journal |
| issn | 2213-2317 |
| language | English |
| last_indexed | 2024-04-10T04:22:06Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Redox Biology |
| spelling | doaj.art-c04cea351cea49b7ad1718ff026ad8242023-03-11T04:19:38ZengElsevierRedox Biology2213-23172023-05-0161102640The influence of vitamin D supplementation and strength training on health biomarkers and chromosomal damage in community-dwelling older adultsAgnes Draxler0Bernhard Franzke1Sanja Kelecevic2Alexander Maier3Jelena Pantic4Simon Srienc5Katharina Cellnigg6Scoris-Marian Solomon7Carina Zötsch8Rudolf Aschauer9Sandra Unterberger10Patrick A. Zöhrer11Laura Bragagna12Eva-Maria Strasser13Barbara Wessner14Karl-Heinz Wagner15Department of Nutritional Sciences, University of Vienna, Austria; Vienna Doctoral School for Pharmaceutical, Nutritional and Sport Sciences (PhaNuSpo), University of Vienna, Josef Holaubek-Platz 2, 1090, Vienna, AustriaDepartment of Nutritional Sciences, University of Vienna, Austria; Research Platform Active Ageing, University of Vienna, AustriaDepartment of Nutritional Sciences, University of Vienna, AustriaDepartment of Nutritional Sciences, University of Vienna, AustriaDepartment of Nutritional Sciences, University of Vienna, AustriaDepartment of Nutritional Sciences, University of Vienna, AustriaDepartment of Nutritional Sciences, University of Vienna, AustriaDepartment of Nutritional Sciences, University of Vienna, AustriaDepartment of Nutritional Sciences, University of Vienna, AustriaDepartment of Nutritional Sciences, University of Vienna, Austria; Centre for Sport Science and University Sports, University of Vienna, Austria; Vienna Doctoral School for Pharmaceutical, Nutritional and Sport Sciences (PhaNuSpo), University of Vienna, Josef Holaubek-Platz 2, 1090, Vienna, AustriaDepartment of Nutritional Sciences, University of Vienna, Austria; Centre for Sport Science and University Sports, University of Vienna, Austria; Vienna Doctoral School for Pharmaceutical, Nutritional and Sport Sciences (PhaNuSpo), University of Vienna, Josef Holaubek-Platz 2, 1090, Vienna, AustriaDepartment of Nutritional Sciences, University of Vienna, Austria; Research Platform Active Ageing, University of Vienna, Austria; Vienna Doctoral School for Pharmaceutical, Nutritional and Sport Sciences (PhaNuSpo), University of Vienna, Josef Holaubek-Platz 2, 1090, Vienna, AustriaDepartment of Nutritional Sciences, University of Vienna, Austria; Vienna Doctoral School for Pharmaceutical, Nutritional and Sport Sciences (PhaNuSpo), University of Vienna, Josef Holaubek-Platz 2, 1090, Vienna, AustriaKarl Landsteiner Institute for Remobilization and Functional Health/Institute for Physical Medicine and Rehabilitation, Kaiser Franz Joseph Hospital, Social Medical Center South, Vienna, AustriaResearch Platform Active Ageing, University of Vienna, Austria; Centre for Sport Science and University Sports, University of Vienna, Austria; Vienna Doctoral School for Pharmaceutical, Nutritional and Sport Sciences (PhaNuSpo), University of Vienna, Josef Holaubek-Platz 2, 1090, Vienna, AustriaDepartment of Nutritional Sciences, University of Vienna, Austria; Research Platform Active Ageing, University of Vienna, Austria; Corresponding author. Department of Nutritional Sciences, University of Vienna, Austria.Older adults lack of proper physical activity which is often accompanied by vitamin D deficiency. Those factors are known to contribute to health issues in the later years of life. The main goal of this intervention study was to investigate the effect of different vitamin D supplementation strategies for 4 weeks solely or combined with a 10-week strength training program on chromosomal stability in peripheral blood mononuclear cells in community-dwelling older people. One hundred women and men (65–85 years) received either vitamin D3 daily (800 IU), a monthly dose (50.000 IU) or placebo for 17 weeks. All groups received 400 mg calcium daily. The fitness status of the study participants was measured using the 30- second chair stand test, the handgrip strength test and the 6-min walk test. The cytokinesis block micronucleus cytome (CBMN) assay was applied to analyze chromosomal anomalies, including cytotoxic and genotoxic parameters. Changes in antioxidant markers were measured in plasma.Walking distance and chair stand performance improved significantly. Increased levels of the parameters of the CBMN assay were detected for all intervention groups at study end. At baseline micronuclei (MNi) frequency correlated significantly with BMI in both sexes (females: r = 0.369, p = 0.034; males: r = 0.265, p = 0.035), but not with vitamin D serum levels. In females, body fat (r = 0.372, p < 0.001) and functional parameter using the 30-s chair stand test (r = 0.311, p = 0.002) correlated significantly with MNi frequency. Interestingly, not vitamin D supplementation but 10 weeks of resistance training increased MNi frequency indicating elevated chromosomal instability and also adverse effects on antioxidant markers including glutathione and FRAP were detected in the group of community-dwelling older adults.http://www.sciencedirect.com/science/article/pii/S2213231723000411DNA instabilityMicronuclei frequencyChromosome abnormalityCholecalciferolVitamin D supplementationElderly |
| spellingShingle | Agnes Draxler Bernhard Franzke Sanja Kelecevic Alexander Maier Jelena Pantic Simon Srienc Katharina Cellnigg Scoris-Marian Solomon Carina Zötsch Rudolf Aschauer Sandra Unterberger Patrick A. Zöhrer Laura Bragagna Eva-Maria Strasser Barbara Wessner Karl-Heinz Wagner The influence of vitamin D supplementation and strength training on health biomarkers and chromosomal damage in community-dwelling older adults Redox Biology DNA instability Micronuclei frequency Chromosome abnormality Cholecalciferol Vitamin D supplementation Elderly |
| title | The influence of vitamin D supplementation and strength training on health biomarkers and chromosomal damage in community-dwelling older adults |
| title_full | The influence of vitamin D supplementation and strength training on health biomarkers and chromosomal damage in community-dwelling older adults |
| title_fullStr | The influence of vitamin D supplementation and strength training on health biomarkers and chromosomal damage in community-dwelling older adults |
| title_full_unstemmed | The influence of vitamin D supplementation and strength training on health biomarkers and chromosomal damage in community-dwelling older adults |
| title_short | The influence of vitamin D supplementation and strength training on health biomarkers and chromosomal damage in community-dwelling older adults |
| title_sort | influence of vitamin d supplementation and strength training on health biomarkers and chromosomal damage in community dwelling older adults |
| topic | DNA instability Micronuclei frequency Chromosome abnormality Cholecalciferol Vitamin D supplementation Elderly |
| url | http://www.sciencedirect.com/science/article/pii/S2213231723000411 |
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