Sulfated Hyaluronan Derivatives Modulate TGF-β1:Receptor Complex Formation: Possible Consequences for TGF-β1 Signaling

Sulfated Hyaluronan Derivatives Modulate TGF-β1:Receptor Complex Formation: Possible Consequences for TGF-β1 Signaling

Abstract Glycosaminoglycans are known to bind biological mediators thereby modulating their biological activity. Sulfated hyaluronans (sHA) were reported to strongly interact with transforming growth factor (TGF)-β1 leading to impaired bioactivity in fibroblasts. The underlying mechanism is not full...

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Bibliographic Details
Main Authors: Linda Koehler, Sergey Samsonov, Sandra Rother, Sarah Vogel, Sebastian Köhling, Stephanie Moeller, Matthias Schnabelrauch, Jörg Rademann, Ute Hempel, M. Teresa Pisabarro, Dieter Scharnweber, Vera Hintze
Format: Article
Language:English
Published: Nature Portfolio 2017-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-01264-8

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