Mechanisms of drug resistance in breast cancer liver metastases: Dilemmas and opportunities
Breast cancer is the leading cause of cancer-related deaths in females worldwide, and the liver is one of the most common sites of distant metastases in breast cancer patients. Patients with breast cancer liver metastases face limited treatment options, and drug resistance is highly prevalent, leadi...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-03-01
|
| Series: | Molecular Therapy: Oncolytics |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2372770523000098 |
| _version_ | 1797903402333634560 |
|---|---|
| author | Chun-Yan Yan Meng-Lu Zhao Ya-Nan Wei Xi-He Zhao |
| author_facet | Chun-Yan Yan Meng-Lu Zhao Ya-Nan Wei Xi-He Zhao |
| author_sort | Chun-Yan Yan |
| collection | DOAJ |
| description | Breast cancer is the leading cause of cancer-related deaths in females worldwide, and the liver is one of the most common sites of distant metastases in breast cancer patients. Patients with breast cancer liver metastases face limited treatment options, and drug resistance is highly prevalent, leading to a poor prognosis and a short survival. Liver metastases respond extremely poorly to immunotherapy and have shown resistance to treatments such as chemotherapy and targeted therapies. Therefore, to develop and to optimize treatment strategies as well as to explore potential therapeutic approaches, it is crucial to understand the mechanisms of drug resistance in breast cancer liver metastases patients. In this review, we summarize recent advances in the research of drug resistance mechanisms in breast cancer liver metastases and discuss their therapeutic potential for improving patient prognoses and outcomes. |
| first_indexed | 2024-04-10T09:32:19Z |
| format | Article |
| id | doaj.art-c050d6786a694aff838b0de7945665ca |
| institution | Directory Open Access Journal |
| issn | 2372-7705 |
| language | English |
| last_indexed | 2024-04-10T09:32:19Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Therapy: Oncolytics |
| spelling | doaj.art-c050d6786a694aff838b0de7945665ca2023-02-19T04:26:09ZengElsevierMolecular Therapy: Oncolytics2372-77052023-03-0128212229Mechanisms of drug resistance in breast cancer liver metastases: Dilemmas and opportunitiesChun-Yan Yan0Meng-Lu Zhao1Ya-Nan Wei2Xi-He Zhao3Department of Clinical Oncology, Shengjing Hospital of China Medical University, Shenyang 110022, People’s Republic of ChinaDepartment of Clinical Oncology, Shengjing Hospital of China Medical University, Shenyang 110022, People’s Republic of ChinaDepartment of Clinical Oncology, Shengjing Hospital of China Medical University, Shenyang 110022, People’s Republic of ChinaDepartment of Clinical Oncology, Shengjing Hospital of China Medical University, Shenyang 110022, People’s Republic of China; Corresponding author: Xi-He Zhao, MD, PhD, Department of Clinical Oncology, Shengjing Hospital of China Medical University, Shenyang 110022, People’s Republic of China.Breast cancer is the leading cause of cancer-related deaths in females worldwide, and the liver is one of the most common sites of distant metastases in breast cancer patients. Patients with breast cancer liver metastases face limited treatment options, and drug resistance is highly prevalent, leading to a poor prognosis and a short survival. Liver metastases respond extremely poorly to immunotherapy and have shown resistance to treatments such as chemotherapy and targeted therapies. Therefore, to develop and to optimize treatment strategies as well as to explore potential therapeutic approaches, it is crucial to understand the mechanisms of drug resistance in breast cancer liver metastases patients. In this review, we summarize recent advances in the research of drug resistance mechanisms in breast cancer liver metastases and discuss their therapeutic potential for improving patient prognoses and outcomes.http://www.sciencedirect.com/science/article/pii/S2372770523000098breast cancerliver metastasesdrug resistancetumor microenvironmentmetabolic microenvironment |
| spellingShingle | Chun-Yan Yan Meng-Lu Zhao Ya-Nan Wei Xi-He Zhao Mechanisms of drug resistance in breast cancer liver metastases: Dilemmas and opportunities Molecular Therapy: Oncolytics breast cancer liver metastases drug resistance tumor microenvironment metabolic microenvironment |
| title | Mechanisms of drug resistance in breast cancer liver metastases: Dilemmas and opportunities |
| title_full | Mechanisms of drug resistance in breast cancer liver metastases: Dilemmas and opportunities |
| title_fullStr | Mechanisms of drug resistance in breast cancer liver metastases: Dilemmas and opportunities |
| title_full_unstemmed | Mechanisms of drug resistance in breast cancer liver metastases: Dilemmas and opportunities |
| title_short | Mechanisms of drug resistance in breast cancer liver metastases: Dilemmas and opportunities |
| title_sort | mechanisms of drug resistance in breast cancer liver metastases dilemmas and opportunities |
| topic | breast cancer liver metastases drug resistance tumor microenvironment metabolic microenvironment |
| url | http://www.sciencedirect.com/science/article/pii/S2372770523000098 |
| work_keys_str_mv | AT chunyanyan mechanismsofdrugresistanceinbreastcancerlivermetastasesdilemmasandopportunities AT mengluzhao mechanismsofdrugresistanceinbreastcancerlivermetastasesdilemmasandopportunities AT yananwei mechanismsofdrugresistanceinbreastcancerlivermetastasesdilemmasandopportunities AT xihezhao mechanismsofdrugresistanceinbreastcancerlivermetastasesdilemmasandopportunities |