Overexpression of Kcnmb2 in Dorsal CA1 of Offspring Mice Rescues Hippocampal Dysfunction Caused by a Methyl Donor-Rich Paternal Diet

Overexpression of Kcnmb2 in Dorsal CA1 of Offspring Mice Rescues Hippocampal Dysfunction Caused by a Methyl Donor-Rich Paternal Diet

BK channels are known regulators of neuronal excitability, synaptic plasticity, and memory. Our previous study showed that a paternal methyl donor-rich diet reduced the expression of Kcnmb2, which encodes BK channel subunit beta 2, and caused memory deficits in offspring mice. To explore the underly...

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Bibliographic Details
Main Authors: Ming Yu, Li Guo, Nan Li, Kristin S. Henzel, Huating Gu, Xiufang Ran, Wei Sun, Shuai Liu, Yingchang Lu, Dan Ehninger, Yu Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
BK channels
Kcnmb2
hippocampus
memory
offspring
paternal diet
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00360/full

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