New Insights into Cellular Functions of Nuclear Actin
Actin is one of the most abundant proteins in eukaryotic cells. There are different pools of nuclear actin often undetectable by conventional staining and commercial antibodies used to identify cytoplasmic actin. With the development of more sophisticated imaging and analytical techniques, it became...
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MDPI AG
2021-04-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/10/4/304 |
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| author | Malgorzata Kloc Priyanka Chanana Nicole Vaughn Ahmed Uosef Jacek Z. Kubiak Rafik M. Ghobrial |
| author_facet | Malgorzata Kloc Priyanka Chanana Nicole Vaughn Ahmed Uosef Jacek Z. Kubiak Rafik M. Ghobrial |
| author_sort | Malgorzata Kloc |
| collection | DOAJ |
| description | Actin is one of the most abundant proteins in eukaryotic cells. There are different pools of nuclear actin often undetectable by conventional staining and commercial antibodies used to identify cytoplasmic actin. With the development of more sophisticated imaging and analytical techniques, it became clear that nuclear actin plays a crucial role in shaping the chromatin, genomic, and epigenetic landscape, transcriptional regulation, and DNA repair. This multifaceted role of nuclear actin is not only important for the function of the individual cell but also for the establishment of cell fate, and tissue and organ differentiation during development. Moreover, the changes in the nuclear, chromatin, and genomic architecture are preamble to various diseases. Here, we discuss some of the newly described functions of nuclear actin. |
| first_indexed | 2024-03-10T12:33:09Z |
| format | Article |
| id | doaj.art-c05341b4565a496582cdefc5b647b1db |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-10T12:33:09Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-c05341b4565a496582cdefc5b647b1db2023-11-21T14:28:48ZengMDPI AGBiology2079-77372021-04-0110430410.3390/biology10040304New Insights into Cellular Functions of Nuclear ActinMalgorzata Kloc0Priyanka Chanana1Nicole Vaughn2Ahmed Uosef3Jacek Z. Kubiak4Rafik M. Ghobrial5The Houston Methodist Research Institute, Houston, TX 77030, USAThe Houston Methodist Research Institute, Houston, TX 77030, USAThe Houston Methodist Research Institute, Houston, TX 77030, USAThe Houston Methodist Research Institute, Houston, TX 77030, USADepartment of Regenerative Medicine and Cell Biology, Military Institute of Hygiene and Epidemiology (WIHE), 01-163 Warsaw, PolandThe Houston Methodist Research Institute, Houston, TX 77030, USAActin is one of the most abundant proteins in eukaryotic cells. There are different pools of nuclear actin often undetectable by conventional staining and commercial antibodies used to identify cytoplasmic actin. With the development of more sophisticated imaging and analytical techniques, it became clear that nuclear actin plays a crucial role in shaping the chromatin, genomic, and epigenetic landscape, transcriptional regulation, and DNA repair. This multifaceted role of nuclear actin is not only important for the function of the individual cell but also for the establishment of cell fate, and tissue and organ differentiation during development. Moreover, the changes in the nuclear, chromatin, and genomic architecture are preamble to various diseases. Here, we discuss some of the newly described functions of nuclear actin.https://www.mdpi.com/2079-7737/10/4/304nuclear actinnuclear architectureintranuclear rodsRhoAF actinG actin |
| spellingShingle | Malgorzata Kloc Priyanka Chanana Nicole Vaughn Ahmed Uosef Jacek Z. Kubiak Rafik M. Ghobrial New Insights into Cellular Functions of Nuclear Actin Biology nuclear actin nuclear architecture intranuclear rods RhoA F actin G actin |
| title | New Insights into Cellular Functions of Nuclear Actin |
| title_full | New Insights into Cellular Functions of Nuclear Actin |
| title_fullStr | New Insights into Cellular Functions of Nuclear Actin |
| title_full_unstemmed | New Insights into Cellular Functions of Nuclear Actin |
| title_short | New Insights into Cellular Functions of Nuclear Actin |
| title_sort | new insights into cellular functions of nuclear actin |
| topic | nuclear actin nuclear architecture intranuclear rods RhoA F actin G actin |
| url | https://www.mdpi.com/2079-7737/10/4/304 |
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