Evaluation of genotoxic and antigenotoxic properties of essential oils of Seseli rigidum Waldst. & Kit. (Apiaceae)
The essential oils of genus Seseli are known for their beneficial biological activities and could present novel targets in the development of safe and effective preparations of plant products. The objective was to test the essential oils of different parts of Seseli rigidum from two natural...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
University of Belgrade, University of Novi Sad
2016-01-01
|
| Series: | Archives of Biological Sciences |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-4664/2016/0354-46641500135Z.pdf |
| Summary: | The essential oils of genus Seseli are known for their beneficial biological
activities and could present novel targets in the development of safe and
effective preparations of plant products. The objective was to test the
essential oils of different parts of Seseli rigidum from two natural habitats
for potential genotoxic and antigenotoxic activities against H202-induced DNA
damage in human whole blood cells in vitro, by the comet assay. The essential
oil analysis showed a high falcarinol content in oil from the root, while
oils of the fruit and aerial parts contained α-pinene as the main compound.
Genotoxicity was not detected at any of the concentrations of the essential
oils from the three parts of the plant from localities I and II. Although the
antioxidant activity (established by the FRAP and DPPH tests) of the
investigated oils was low, all oils demonstrated a strong antigenotoxic
effect against H2O2-induced damage post-treatment, when the oils were applied
after the oxidant. Based on the lack of pretreatment activity and the
post-treatment reduction in DNA damage, the antigenotoxic effect of S.
rigidum essential oils was probably based on the stimulation of DNA repair
mechanisms. Environmental conditions did not affect the antigenotoxic
properties of the oils. In conclusion, our results revealed the antigenotoxic
properties of S. rigidum essential oils and appropriate and safe doses with
beneficial effects under the described conditions. [Projekat Ministarstva
nauke Republike Srbije, br. OI 173034, 173021] |
|---|---|
| ISSN: | 0354-4664 1821-4339 |