Unravelling Phytochemical and Bioactive Potential of Three <i>Hypericum</i> Species from Romanian Spontaneous Flora: <i>H. alpigenum</i>, <i>H.</i> <i>perforatum</i> and <i>H. rochelii</i>
<i>Hypericum perforatum</i> L., also known as St. John’s Wort, is recognized worldwide as a valuable medicinal herb; however, other <i>Hypericum</i> species were intensively studied for their bioactive potential. To fill the research gap that exists in the scientific literatu...
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| Format: | Article |
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MDPI AG
2022-10-01
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| Series: | Plants |
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| Online Access: | https://www.mdpi.com/2223-7747/11/20/2773 |
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| author | Mihai Babotă Oleg Frumuzachi Andrei Mocan Mircea Tămaș Maria Inês Dias José Pinela Dejan Stojković Marina Soković Alexandru Sabin Bădărău Gianina Crișan Lillian Barros Ramona Păltinean |
| author_facet | Mihai Babotă Oleg Frumuzachi Andrei Mocan Mircea Tămaș Maria Inês Dias José Pinela Dejan Stojković Marina Soković Alexandru Sabin Bădărău Gianina Crișan Lillian Barros Ramona Păltinean |
| author_sort | Mihai Babotă |
| collection | DOAJ |
| description | <i>Hypericum perforatum</i> L., also known as St. John’s Wort, is recognized worldwide as a valuable medicinal herb; however, other <i>Hypericum</i> species were intensively studied for their bioactive potential. To fill the research gap that exists in the scientific literature, a comparative evaluation between <i>H. alpigenum</i> Kit., <i>H.</i> <i>perforatum</i> L. and <i>H. rochelii</i> Griseb. & Schenk was conducted in the present study. Two types of herbal preparations obtained from the aerial parts of these species were analyzed: extracts obtained through maceration and extracts obtained through magnetic-stirring-assisted extraction. LC-DAD-ESI-MS<sup>n</sup> analysis revealed the presence of phenolic acids, flavan-3-ols and flavonoid derivatives as the main constituents of the above-mentioned species. Moreover, all extracts were tested for their antioxidant, enzyme-inhibitory and antimicrobial potential. Our work emphasizes for the first time a detailed description of <i>H. rochelii</i> phenolic fractions, including their phytochemical and bioactive characterization. In comparison with the other two studied species, <i>H. rochelii</i> was found as a rich source of phenolic acids and myricetin derivatives, showing important antioxidant, anticholinesterase and antibacterial activity. The study offers new perspectives regarding the chemical and bioactive profile of the less-studied species <i>H. alpigenum</i> and <i>H. rochelii</i>. |
| first_indexed | 2024-03-09T19:33:57Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-09T19:33:57Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj.art-c054dbc4749a47ef9f9095cf77a5515b2023-11-24T02:05:09ZengMDPI AGPlants2223-77472022-10-011120277310.3390/plants11202773Unravelling Phytochemical and Bioactive Potential of Three <i>Hypericum</i> Species from Romanian Spontaneous Flora: <i>H. alpigenum</i>, <i>H.</i> <i>perforatum</i> and <i>H. rochelii</i>Mihai Babotă0Oleg Frumuzachi1Andrei Mocan2Mircea Tămaș3Maria Inês Dias4José Pinela5Dejan Stojković6Marina Soković7Alexandru Sabin Bădărău8Gianina Crișan9Lillian Barros10Ramona Păltinean11Department of Pharmaceutical Botany, “Iuliu Hațieganu” University of Medicine and Pharmacy, Gheorghe Marinescu Street 23, 400337 Cluj-Napoca, RomaniaDepartment of Pharmaceutical Botany, “Iuliu Hațieganu” University of Medicine and Pharmacy, Gheorghe Marinescu Street 23, 400337 Cluj-Napoca, RomaniaDepartment of Pharmaceutical Botany, “Iuliu Hațieganu” University of Medicine and Pharmacy, Gheorghe Marinescu Street 23, 400337 Cluj-Napoca, RomaniaDepartment of Pharmaceutical Botany, “Iuliu Hațieganu” University of Medicine and Pharmacy, Gheorghe Marinescu Street 23, 400337 Cluj-Napoca, RomaniaCentro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, PortugalCentro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, PortugalInstitute for Biological Research “Siniša Stanković”-National Institute of Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11060 Belgrade, SerbiaInstitute for Biological Research “Siniša Stanković”-National Institute of Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11060 Belgrade, SerbiaFaculty of Environmental Sciences and Engineering, Babeș-Bolyai University, 30, Fântânele Street, 400294 Cluj-Napoca, RomaniaDepartment of Pharmaceutical Botany, “Iuliu Hațieganu” University of Medicine and Pharmacy, Gheorghe Marinescu Street 23, 400337 Cluj-Napoca, RomaniaCentro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, PortugalDepartment of Pharmaceutical Botany, “Iuliu Hațieganu” University of Medicine and Pharmacy, Gheorghe Marinescu Street 23, 400337 Cluj-Napoca, Romania<i>Hypericum perforatum</i> L., also known as St. John’s Wort, is recognized worldwide as a valuable medicinal herb; however, other <i>Hypericum</i> species were intensively studied for their bioactive potential. To fill the research gap that exists in the scientific literature, a comparative evaluation between <i>H. alpigenum</i> Kit., <i>H.</i> <i>perforatum</i> L. and <i>H. rochelii</i> Griseb. & Schenk was conducted in the present study. Two types of herbal preparations obtained from the aerial parts of these species were analyzed: extracts obtained through maceration and extracts obtained through magnetic-stirring-assisted extraction. LC-DAD-ESI-MS<sup>n</sup> analysis revealed the presence of phenolic acids, flavan-3-ols and flavonoid derivatives as the main constituents of the above-mentioned species. Moreover, all extracts were tested for their antioxidant, enzyme-inhibitory and antimicrobial potential. Our work emphasizes for the first time a detailed description of <i>H. rochelii</i> phenolic fractions, including their phytochemical and bioactive characterization. In comparison with the other two studied species, <i>H. rochelii</i> was found as a rich source of phenolic acids and myricetin derivatives, showing important antioxidant, anticholinesterase and antibacterial activity. The study offers new perspectives regarding the chemical and bioactive profile of the less-studied species <i>H. alpigenum</i> and <i>H. rochelii</i>.https://www.mdpi.com/2223-7747/11/20/2773<i>Hypericum</i> species<i>Hypericum rochelii</i><i>Hypericum alpigenum</i>antioxidant activityenzyme inhibition |
| spellingShingle | Mihai Babotă Oleg Frumuzachi Andrei Mocan Mircea Tămaș Maria Inês Dias José Pinela Dejan Stojković Marina Soković Alexandru Sabin Bădărău Gianina Crișan Lillian Barros Ramona Păltinean Unravelling Phytochemical and Bioactive Potential of Three <i>Hypericum</i> Species from Romanian Spontaneous Flora: <i>H. alpigenum</i>, <i>H.</i> <i>perforatum</i> and <i>H. rochelii</i> Plants <i>Hypericum</i> species <i>Hypericum rochelii</i> <i>Hypericum alpigenum</i> antioxidant activity enzyme inhibition |
| title | Unravelling Phytochemical and Bioactive Potential of Three <i>Hypericum</i> Species from Romanian Spontaneous Flora: <i>H. alpigenum</i>, <i>H.</i> <i>perforatum</i> and <i>H. rochelii</i> |
| title_full | Unravelling Phytochemical and Bioactive Potential of Three <i>Hypericum</i> Species from Romanian Spontaneous Flora: <i>H. alpigenum</i>, <i>H.</i> <i>perforatum</i> and <i>H. rochelii</i> |
| title_fullStr | Unravelling Phytochemical and Bioactive Potential of Three <i>Hypericum</i> Species from Romanian Spontaneous Flora: <i>H. alpigenum</i>, <i>H.</i> <i>perforatum</i> and <i>H. rochelii</i> |
| title_full_unstemmed | Unravelling Phytochemical and Bioactive Potential of Three <i>Hypericum</i> Species from Romanian Spontaneous Flora: <i>H. alpigenum</i>, <i>H.</i> <i>perforatum</i> and <i>H. rochelii</i> |
| title_short | Unravelling Phytochemical and Bioactive Potential of Three <i>Hypericum</i> Species from Romanian Spontaneous Flora: <i>H. alpigenum</i>, <i>H.</i> <i>perforatum</i> and <i>H. rochelii</i> |
| title_sort | unravelling phytochemical and bioactive potential of three i hypericum i species from romanian spontaneous flora i h alpigenum i i h i i perforatum i and i h rochelii i |
| topic | <i>Hypericum</i> species <i>Hypericum rochelii</i> <i>Hypericum alpigenum</i> antioxidant activity enzyme inhibition |
| url | https://www.mdpi.com/2223-7747/11/20/2773 |
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