Predicting Prognosis and Platinum Resistance in Ovarian Cancer: Role of Immunohistochemistry Biomarkers
Ovarian cancer is a lethal reproductive tumour affecting women worldwide. The advancement in presentation and occurrence of chemoresistance are the key factors for poor survival among ovarian cancer women. Surgical debulking was the mainstay of systemic treatment for ovarian cancer, which was follow...
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MDPI AG
2023-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/3/1973 |
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| author | Ghofraan Abdulsalam Atallah Nirmala Chandralega Kampan Kah Teik Chew Norfilza Mohd Mokhtar Reena Rahayu Md Zin Mohamad Nasir bin Shafiee Nor Haslinda binti Abd. Aziz |
| author_facet | Ghofraan Abdulsalam Atallah Nirmala Chandralega Kampan Kah Teik Chew Norfilza Mohd Mokhtar Reena Rahayu Md Zin Mohamad Nasir bin Shafiee Nor Haslinda binti Abd. Aziz |
| author_sort | Ghofraan Abdulsalam Atallah |
| collection | DOAJ |
| description | Ovarian cancer is a lethal reproductive tumour affecting women worldwide. The advancement in presentation and occurrence of chemoresistance are the key factors for poor survival among ovarian cancer women. Surgical debulking was the mainstay of systemic treatment for ovarian cancer, which was followed by a successful start to platinum-based chemotherapy. However, most women develop platinum resistance and relapse within six months of receiving first-line treatment. Thus, there is a great need to identify biomarkers to predict platinum resistance before enrolment into chemotherapy, which would facilitate individualized targeted therapy for these subgroups of patients to ensure better survival and an improved quality of life and overall outcome. Harnessing the immune response through immunotherapy approaches has changed the treatment way for patients with cancer. The immune outline has emerged as a beneficial tool for recognizing predictive and prognostic biomarkers clinically. Studying the tumour microenvironment (TME) of ovarian cancer tissue may provide awareness of actionable targets for enhancing chemotherapy outcomes and quality of life. This review analyses the relevance of immunohistochemistry biomarkers as prognostic biomarkers in predicting chemotherapy resistance and improving the quality of life in ovarian cancer. |
| first_indexed | 2024-03-11T09:43:08Z |
| format | Article |
| id | doaj.art-c054f185fe6f450ba79f469d34f426e8 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:43:08Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-c054f185fe6f450ba79f469d34f426e82023-11-16T16:50:25ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-01-01243197310.3390/ijms24031973Predicting Prognosis and Platinum Resistance in Ovarian Cancer: Role of Immunohistochemistry BiomarkersGhofraan Abdulsalam Atallah0Nirmala Chandralega Kampan1Kah Teik Chew2Norfilza Mohd Mokhtar3Reena Rahayu Md Zin4Mohamad Nasir bin Shafiee5Nor Haslinda binti Abd. Aziz6Department of Obstetrics and Gynaecology, Faculty of Medicine, University Kebangsaan Malaysia, Bandar Tun Razak 56000, Kuala Lumpur, MalaysiaDepartment of Obstetrics and Gynaecology, Faculty of Medicine, University Kebangsaan Malaysia, Bandar Tun Razak 56000, Kuala Lumpur, MalaysiaDepartment of Obstetrics and Gynaecology, Faculty of Medicine, University Kebangsaan Malaysia, Bandar Tun Razak 56000, Kuala Lumpur, MalaysiaDepartment of Physiology, Faculty of Medicine, University Kebangsaan Malaysia, Bandar Tun Razak 56000, Kuala Lumpur, MalaysiaDepartment of Pathology, Faculty of Medicine, University Kebangsaan Malaysia, Bandar Tun Razak 56000, Kuala Lumpur, MalaysiaDepartment of Obstetrics and Gynaecology, Faculty of Medicine, University Kebangsaan Malaysia, Bandar Tun Razak 56000, Kuala Lumpur, MalaysiaDepartment of Obstetrics and Gynaecology, Faculty of Medicine, University Kebangsaan Malaysia, Bandar Tun Razak 56000, Kuala Lumpur, MalaysiaOvarian cancer is a lethal reproductive tumour affecting women worldwide. The advancement in presentation and occurrence of chemoresistance are the key factors for poor survival among ovarian cancer women. Surgical debulking was the mainstay of systemic treatment for ovarian cancer, which was followed by a successful start to platinum-based chemotherapy. However, most women develop platinum resistance and relapse within six months of receiving first-line treatment. Thus, there is a great need to identify biomarkers to predict platinum resistance before enrolment into chemotherapy, which would facilitate individualized targeted therapy for these subgroups of patients to ensure better survival and an improved quality of life and overall outcome. Harnessing the immune response through immunotherapy approaches has changed the treatment way for patients with cancer. The immune outline has emerged as a beneficial tool for recognizing predictive and prognostic biomarkers clinically. Studying the tumour microenvironment (TME) of ovarian cancer tissue may provide awareness of actionable targets for enhancing chemotherapy outcomes and quality of life. This review analyses the relevance of immunohistochemistry biomarkers as prognostic biomarkers in predicting chemotherapy resistance and improving the quality of life in ovarian cancer.https://www.mdpi.com/1422-0067/24/3/1973immunohistochemistrybiomarkersplatinum chemotherapychemotherapy resistancedisease relapseovarian cancer |
| spellingShingle | Ghofraan Abdulsalam Atallah Nirmala Chandralega Kampan Kah Teik Chew Norfilza Mohd Mokhtar Reena Rahayu Md Zin Mohamad Nasir bin Shafiee Nor Haslinda binti Abd. Aziz Predicting Prognosis and Platinum Resistance in Ovarian Cancer: Role of Immunohistochemistry Biomarkers International Journal of Molecular Sciences immunohistochemistry biomarkers platinum chemotherapy chemotherapy resistance disease relapse ovarian cancer |
| title | Predicting Prognosis and Platinum Resistance in Ovarian Cancer: Role of Immunohistochemistry Biomarkers |
| title_full | Predicting Prognosis and Platinum Resistance in Ovarian Cancer: Role of Immunohistochemistry Biomarkers |
| title_fullStr | Predicting Prognosis and Platinum Resistance in Ovarian Cancer: Role of Immunohistochemistry Biomarkers |
| title_full_unstemmed | Predicting Prognosis and Platinum Resistance in Ovarian Cancer: Role of Immunohistochemistry Biomarkers |
| title_short | Predicting Prognosis and Platinum Resistance in Ovarian Cancer: Role of Immunohistochemistry Biomarkers |
| title_sort | predicting prognosis and platinum resistance in ovarian cancer role of immunohistochemistry biomarkers |
| topic | immunohistochemistry biomarkers platinum chemotherapy chemotherapy resistance disease relapse ovarian cancer |
| url | https://www.mdpi.com/1422-0067/24/3/1973 |
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