eIF5A is activated by virus infection or dsRNA and facilitates virus replication through modulation of interferon production

eIF5A is activated by virus infection or dsRNA and facilitates virus replication through modulation of interferon production

Active hypusine-modified initiation elongation factor 5A is critical for cell proliferation and differentiation, embryonic development, and innate immune response of macrophages to bacterial infection. Here, we demonstrate that both virus infection and double-stranded RNA viral mimic stimulation ind...

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Bibliographic Details
Main Authors: Rocío Seoane, Yessica Y. Llamas-González, Santiago Vidal, Ahmed El Motiam, Yanis Hichem Bouzaher, Danae Fonseca, Rosa Farrás, Adolfo García-Sastre, José González-Santamaría, Carmen Rivas
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
eIF5A1
hypusine
virus
dsRNA
GC7
influenza
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.960138/full

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